UniProt Q09428
ATP-binding cassette sub-family C member 8 (Q09428)
ATP-binding cassette sub-family C member 8 (UniProt Q09428): 11 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q09428
- Protein
- ATP-binding cassette sub-family C member 8
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 17 · 1 record with a druggable one
Structures
12 records of Q09428 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6C3O | Cryo-EM structure of human katp bound to ATP and ADP in quatrefoil form | electron microscopy | E, H, G, F | ADP, MG, ATP | — |
| 6C3P | Cryo-EM structure of human KATP bound to ATP and ADP in propeller form | electron microscopy | E, H, G, F | ADP, MG, ATP | 17 (best 0.90) |
| 6C3P | Cryo-EM structure of human katp bound to ATP and ADP in propeller form | electron microscopy | E, H, G, F | ADP, MG, ATP | — |
| 7S5V | Human katp channel in open conformation, focused on sur | electron microscopy | E | ADP, MG, ATP | — |
| 7S5X | Human KATP channel in open conformation, focused on Kir and one SUR, position 1 | electron microscopy | E | ADP, MG, ATP | — |
| 7S5X | Human katp channel in open conformation, focused on kir and one sur, position 1 | electron microscopy | E | ADP, MG, ATP | — |
| 7S5Y | Human katp channel in open conformation, focused on kir and one sur, position 2 | electron microscopy | E | ADP, MG, ATP | — |
| 7S5Z | Human katp channel in open conformation, focused on kir and one sur, position 3 | electron microscopy | E | ADP, MG, ATP | — |
| 7S60 | Human KATP channel in open conformation, focused on Kir and one SUR, position 4 | electron microscopy | E | ADP, MG, ATP | — |
| 7S60 | Human katp channel in open conformation, focused on kir and one sur, position 4 | electron microscopy | E | ADP, MG, ATP | — |
| 7S61 | Human katp channel in open conformation, focused on kir and one sur, position 5 | electron microscopy | E | ADP, MG, ATP | — |
| Q09428 | AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family C member 8 (Q09428) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7S5Y chain E against the predicted model Q09428: TM-score 0.87, RMSD 5.05 Å
- 7S60 chain E against the predicted model Q09428: TM-score 0.87, RMSD 5.05 Å
- 7S60 chain E against the predicted model Q09428: TM-score 0.87, RMSD 5.05 Å
- 6C3P chain H against the predicted model Q09428: TM-score 0.87, RMSD 5.00 Å
- 6C3P chain H against the predicted model Q09428: TM-score 0.87, RMSD 5.00 Å
- 6C3P chain E against the predicted model Q09428: TM-score 0.87, RMSD 5.00 Å
- 6C3P chain F against the predicted model Q09428: TM-score 0.87, RMSD 5.00 Å
- 6C3P chain E against the predicted model Q09428: TM-score 0.87, RMSD 5.00 Å
- 6C3P chain F against the predicted model Q09428: TM-score 0.87, RMSD 5.00 Å
- 6C3P chain G against the predicted model Q09428: TM-score 0.87, RMSD 5.00 Å
Elsewhere
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