UniProt Q07457
E3 ubiquitin-protein ligase BRE1 (Q07457)
E3 ubiquitin-protein ligase BRE1 (UniProt Q07457), EC 2.3.2.27: 8 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 19 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q07457
- Protein
- E3 ubiquitin-protein ligase BRE1
- EC
- 2.3.2.27
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 19 · 6 records with a druggable one
Structures
9 records of Q07457 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4R7E | Structure of Bre1 RING domain | x-ray diffraction | A | — | — |
| 4R7E | Structure of BRE1 ring domain | x-ray diffraction | A | — | — |
| 7UV8 | Rad6-Bre1 Complex | x-ray diffraction | V, U | — | 6 (best 0.64) |
| 7UVC | Rad6(P43L)-Bre1 Complex | x-ray diffraction | V, U | — | 5 (best 0.60) |
| 8IEG | Bre1(mRBD-RING)/Rad6-Ub/nucleosome complex | electron microscopy | A, B | ZN | 2 (best 0.75) |
| 8T3T | Structure of Bre1-nucleosome complex - state3 | electron microscopy | K, L | ZN | 1 (best 0.72) |
| 8T3W | Structure of Bre1-nucleosome complex - state2 | electron microscopy | K, L | ZN | 2 (best 0.70) |
| 8T3Y | Structure of Bre1-nucleosome complex - state1 | electron microscopy | K, L | ZN | 3 (best 0.71) |
| Q07457 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase BRE1 (Q07457) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 4 records
Experiment against prediction
- 4R7E chain A against the predicted model Q07457: TM-score 0.97, RMSD 0.54 Å
- 4R7E chain A against the predicted model Q07457: TM-score 0.97, RMSD 0.54 Å
- 8T3W chain K against the predicted model Q07457: TM-score 0.95, RMSD 0.70 Å
- 8T3Y chain K against the predicted model Q07457: TM-score 0.95, RMSD 0.70 Å
- 8T3T chain L against the predicted model Q07457: TM-score 0.95, RMSD 0.72 Å
- 8IEG chain A against the predicted model Q07457: TM-score 0.94, RMSD 0.73 Å
- 8T3T chain K against the predicted model Q07457: TM-score 0.94, RMSD 0.76 Å
- 8IEG chain B against the predicted model Q07457: TM-score 0.93, RMSD 0.81 Å
- 8T3W chain L against the predicted model Q07457: TM-score 0.92, RMSD 0.90 Å
- 8T3Y chain L against the predicted model Q07457: TM-score 0.92, RMSD 0.90 Å
Elsewhere
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