UniProt Q06830
Peroxiredoxin-1 (Q06830)
Peroxiredoxin-1 (UniProt Q06830), EC 1.11.1.24: 15 experimental structures on GenesisL1, 5 ligands bound, 9 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q06830
- Protein
- Peroxiredoxin-1
- EC
- 1.11.1.24
- Experimental structures
- 15
- Predicted models
- 0
- Ligands
- 5
- Pockets
- 9 · 6 records with a druggable one
Structures
15 records of Q06830 in the MolNFT archive: 15 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2RII | Crystal Structure of Human Peroxiredoxin I in complex with Sulfiredoxin | x-ray diffraction | A, B | — | — |
| 2RII | Crystal structure of human peroxiredoxin I in complex with sulfiredoxin | x-ray diffraction | A, B | — | — |
| 3HY2 | Crystal Structure of Sulfiredoxin in Complex with Peroxiredoxin I and ATP:Mg2+ | x-ray diffraction | A, B | — | — |
| 3HY2 | Crystal structure of sulfiredoxin in complex with peroxiredoxin I and ATP:MG2+ | x-ray diffraction | A, B | — | — |
| 4XCS | Human peroxiredoxin-1 C83S mutant | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4XCS | Human peroxiredoxin-1 C83S mutant | x-ray diffraction | A, B, C, D, E, F | — | — |
| 7LJ1 | Human PRX1-srx decameric complex | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T | PO4, ATP | — |
| 7WET | Crystal structure of Peroxiredoxin I in complex with the inhibitor Cela | x-ray diffraction | A, B | AQR | — |
| 8X71 | Crystal structure of Peroxiredoxin I in complex with compound 19-064 | x-ray diffraction | A, B | YCC | 3 (best 0.70) |
| 8X73 | Crystal structure of Peroxiredoxin I in complex with compound 19-069 | x-ray diffraction | A, B | YC0 | 2 (best 0.62) |
| 8Z54 | Crystal structure of human SIRT5 in complex with succinylated Prx1 fragment | x-ray diffraction | B | — | 1 (best 0.65) |
| 8Z55 | Crystal structure of human SIRT5 in complex with succPrx1 and ADP ribose | x-ray diffraction | B | — | 1 (best 0.62) |
| 8Z56 | Crystal structure of human Q140L-SIRT5 in complex with succinylated Prx1 fragment | x-ray diffraction | B | — | 1 (best 0.64) |
| 8Z57 | Crystal structure of human Q140L-SIRT5 in complex with succinylated Prx1 fragment and ADP ribose | x-ray diffraction | B | — | 1 (best 0.64) |
| Q06830 | AlphaFold monomer V2.0 prediction for peroxiredoxin-1 (Q06830) | — | — | — |
Ligands
- AQR · (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid · in 1 record
- ATP · Adenosine-5'-triphosphate · in 1 record
- PO4 · Phosphate ion · in 1 record
- YC0 · methyl (2~{S})-2-[[(2~{R},4~{a}~{S},6~{a}~{R},6~{a}~{S},14~{a}~{S},14~{b}~{R})-2,4~{a},6~{a},6~{a},9,14~{a}-hexamethyl-10-oxidanyl-11-oxidanylidene-1,3,4,5,6,13,14,14~{b}-octahydropicen-2-yl]carbamoylamino]-3-oxidanyl-propanoate · in 1 record
- YCC · methyl 3-[[(2~{R},4~{a}~{S},6~{a}~{R},6~{a}~{S},14~{a}~{S},14~{b}~{R})-2,4~{a},6~{a},6~{a},9,14~{a}-hexamethyl-10-oxidanyl-11-oxidanylidene-1,3,4,5,6,13,14,14~{b}-octahydropicen-2-yl]carbamoylamino]oxetane-3-carboxylate · in 1 record
Elsewhere
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