UniProt Q06287
Ribosomal RNA small subunit methyltransferase NEP1 (Q06287)
Ribosomal RNA small subunit methyltransferase NEP1 (UniProt Q06287), EC 2.1.1.260: 36 experimental structures and 1 predicted model on GenesisL1, 13 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q06287
- Protein
- Ribosomal RNA small subunit methyltransferase NEP1
- EC
- 2.1.1.260
- Experimental structures
- 36
- Predicted models
- 1
- Pockets
- 13 · 8 records with a druggable one
Structures
37 records of Q06287 in the MolNFT archive: 36 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2V3J | The yeast ribosome synthesis factor Emg1 alpha beta knot fold methyltransferase | x-ray diffraction | A | — | — |
| 2V3J | The yeast ribosome synthesis factor EMG1 alpha beta knot fold methyltransferase | x-ray diffraction | A | — | — |
| 2V3K | The yeast ribosome synthesis factor Emg1 alpha beta knot fold methyltransferase | x-ray diffraction | A | — | — |
| 2V3K | The yeast ribosome synthesis factor EMG1 alpha beta knot fold methyltransferase | x-ray diffraction | A | — | — |
| 3OII | Crystal structure of Saccharomyces Cerevisiae Nep1/Emg1 bound to S-adenosylhomocysteine | x-ray diffraction | A, B | — | — |
| 3OII | Crystal structure of saccharomyces cerevisiae NEP1/EMG1 bound to S- adenosylhomocysteine | x-ray diffraction | A, B | — | — |
| 3OIJ | Crystal structure of Saccharomyces Cerevisiae Nep1/Emg1 bound to S-adenosylhomocysteine and 2… | x-ray diffraction | A, B | — | — |
| 3OIJ | Crystal structure of saccharomyces cerevisiae NEP1/EMG1 bound to S- adenosylhomocysteine and 2… | x-ray diffraction | A, B | — | — |
| 3OIN | Crystal structure of Saccharomyces cerevisiae Nep1/Emg1 bound to S-adenosylhomocysteine and 1… | x-ray diffraction | A, B | — | — |
| 3OIN | Crystal structure of saccharomyces cerevisiae NEP1/EMG1 bound to S- adenosylhomocysteine and 1… | x-ray diffraction | A, B | — | — |
| 5TZS | Architecture of the yeast small subunit processome | electron microscopy | j, k | — | 2 (best 0.84) |
| 5TZS | Architecture of the yeast small subunit processome | electron microscopy | j, k | — | — |
| 5WLC | The complete structure of the small subunit processome | electron microscopy | SJ, SK | — | — |
| 5WYJ | Cryo-EM structure of the 90S small subunit pre-ribosome (Dhr1-depleted, Enp1-TAP, state 1) | electron microscopy | E1, E2 | — | — |
| 5WYK | Cryo-EM structure of the 90S small subunit pre-ribosome (Mtr4-depleted, Enp1-TAP) | electron microscopy | E1, E2 | — | — |
| 6KE6 | 3.4 angstrom cryo-EM structure of yeast 90S small subunit preribosome | electron microscopy | RG, RH | — | — |
| 6LQP | Cryo-EM structure of 90S small subunit preribosomes in transition states (State A) | electron microscopy | RG, RH | — | — |
| 6LQQ | Cryo-EM structure of 90S small subunit preribosomes in transition states (State B) | electron microscopy | RG, RH | — | — |
| 6LQR | Cryo-EM structure of 90S small subunit preribosomes in transition states (State C) | electron microscopy | RG, RH | — | — |
| 6LQS | Cryo-EM structure of 90S small subunit preribosomes in transition states (State D) | electron microscopy | RG, RH | — | — |
| 6LQT | Cryo-EM structure of 90S small subunit preribosomes in transition states (State E) | electron microscopy | RH | — | — |
| 6LQU | Cryo-EM structure of 90S small subunit preribosomes in transition states (State A1) | electron microscopy | RG, RH | — | — |
| 6LQV | Cryo-EM structure of 90S small subunit preribosomes in transition states (State C1) | electron microscopy | RG, RH | — | — |
| 6ZQA | Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state A (Poly-Ala) | electron microscopy | JF, JG | — | 1 (best 0.82) |
| 6ZQB | Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state B2 | electron microscopy | JF, JG | — | — |
| 6ZQC | Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Pre-A1 | electron microscopy | JF, JG | — | — |
| 6ZQD | Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Post-A1 | electron microscopy | JF, JG | — | — |
| 6ZQE | Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Dis-A (Poly-Ala) | electron microscopy | JF, JG | — | 2 (best 0.83) |
| 6ZQF | Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Dis-B (Poly-Ala) | electron microscopy | JF, JG | — | 1 (best 0.86) |
| 6ZQG | Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Dis-C | electron microscopy | JF, JG | — | 1 (best 0.85) |
| 7AJT | Cryo-EM structure of the 90S-exosome super-complex (state Pre-A1-exosome) | electron microscopy | JF, JG | — | — |
| 7AJU | Cryo-EM structure of the 90S-exosome super-complex (state Post-A1-exosome) | electron microscopy | JF, JG | — | — |
| 7D4I | Cryo-EM structure of 90S small ribosomal precursors complex with the DEAH-box RNA helicase Dhr1… | electron microscopy | RG, RH | — | — |
| 7D5S | Cryo-EM structure of 90S preribosome with inactive Utp24 (state A2) | electron microscopy | RG, RH | — | 2 (best 0.85) |
| 7D63 | Cryo-EM structure of 90S preribosome with inactive Utp24 (state C) | electron microscopy | RG, RH | — | 1 (best 0.85) |
| 7SUK | Structure of Bfr2-Lcp5 Complex Observed in the Small Subunit Processome Isolated from R2TP-depleted… | electron microscopy | SJ, SK | — | — |
| Q06287 | AlphaFold monomer V2.0 prediction for ribosomal RNA small subunit methyltransferase NEP1 (Q06287) | predicted | A | — | 3 (best 0.57) |
Experiment against prediction
- 3OII chain A against the predicted model Q06287: TM-score 0.98, RMSD 0.67 Å
- 3OII chain A against the predicted model Q06287: TM-score 0.98, RMSD 0.67 Å
- 3OII chain B against the predicted model Q06287: TM-score 0.98, RMSD 0.68 Å
- 3OII chain B against the predicted model Q06287: TM-score 0.98, RMSD 0.68 Å
- 3OIN chain A against the predicted model Q06287: TM-score 0.98, RMSD 0.86 Å
- 3OIN chain A against the predicted model Q06287: TM-score 0.98, RMSD 0.86 Å
- 6ZQF chain JF against the predicted model Q06287: TM-score 0.98, RMSD 0.80 Å
- 5WLC chain SJ against the predicted model Q06287: TM-score 0.98, RMSD 0.80 Å
- 5WYJ chain E1 against the predicted model Q06287: TM-score 0.98, RMSD 0.90 Å
- 5TZS chain j against the predicted model Q06287: TM-score 0.98, RMSD 0.86 Å
Elsewhere
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