UniProt Q04519
Sphingomyelin phosphodiesterase (Q04519)
Sphingomyelin phosphodiesterase (UniProt Q04519), EC 3.1.4.12: 8 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 15 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q04519
- Protein
- Sphingomyelin phosphodiesterase
- EC
- 3.1.4.12
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 15 · 1 record with a druggable one
Structures
9 records of Q04519 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5FI9 | Closed form of murine Acid Sphingomyelinase in complex with bisphosphonate inhibitor AbPA | x-ray diffraction | A, B | NAG, FUC, ZN, NT8 | — |
| 5FI9 | Closed form of murine acid sphingomyelinase in complex with bisphosphonate inhibitor abpa | x-ray diffraction | A, B | — | — |
| 5FIB | Open form of murine Acid Sphingomyelinase | x-ray diffraction | A, B | NAG, FUC, BMA, MAN, ZN, SO4 | — |
| 5FIB | Open form of murine acid sphingomyelinase | x-ray diffraction | A, B | — | — |
| 5FIC | Open form of murine Acid Sphingomyelinase in presence of lipid | x-ray diffraction | A, B, C, D | NAG, FUC, ZN, PO4, CL, 6E0 | 15 (best 0.80) |
| 5FIC | Open form of murine acid sphingomyelinase in presence of lipid | x-ray diffraction | A, B, C, D | — | — |
| 5HQN | Catalytic domain of murine Acid Sphingomyelinase (ASMase, ASM, SMPD1) | x-ray diffraction | A, B | NAG, FUC, ZN, PO4 | — |
| 5HQN | Catalytic domain of murine acid sphingomyelinase (asmase, asm, SMPD1) | x-ray diffraction | A, B | — | — |
| Q04519 | AlphaFold monomer V2.0 prediction for sphingomyelin phosphodiesterase (Q04519) | predicted | A | — | — |
Ligands
- FUC · alpha-L-fucopyranose · in 4 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
- ZN · Zinc ion · in 4 records
- PO4 · Phosphate ion · in 2 records
- 6E0 · octadecylphosphonic acid · in 1 record
- BMA · beta-D-mannopyranose · in 1 record
- CL · Chloride ion · in 1 record
- MAN · alpha-D-mannopyranose · in 1 record
- NT8 · (1-azanyl-1-phosphono-decyl)phosphonic acid · in 1 record
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 5HQN chain B against the predicted model Q04519: TM-score 0.99, RMSD 0.67 Å
- 5HQN chain B against the predicted model Q04519: TM-score 0.99, RMSD 0.67 Å
- 5HQN chain A against the predicted model Q04519: TM-score 0.99, RMSD 0.67 Å
- 5HQN chain A against the predicted model Q04519: TM-score 0.99, RMSD 0.67 Å
- 5FIC chain D against the predicted model Q04519: TM-score 0.99, RMSD 0.70 Å
- 5FIC chain D against the predicted model Q04519: TM-score 0.99, RMSD 0.70 Å
- 5FIC chain A against the predicted model Q04519: TM-score 0.99, RMSD 0.69 Å
- 5FIC chain A against the predicted model Q04519: TM-score 0.99, RMSD 0.69 Å
- 5FIC chain B against the predicted model Q04519: TM-score 0.99, RMSD 0.81 Å
- 5FIC chain B against the predicted model Q04519: TM-score 0.99, RMSD 0.81 Å
Elsewhere
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