UniProt Q04089
Histone-lysine N-methyltransferase, H3 lysine-79 specific (Q04089)
Histone-lysine N-methyltransferase, H3 lysine-79 specific (UniProt Q04089), EC 2.1.1.360: 5 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 6 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q04089
- Protein
- Histone-lysine N-methyltransferase, H3 lysine-79 specific
- EC
- 2.1.1.360
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 6 · 1 record with a druggable one
Structures
6 records of Q04089 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1U2Z | Crystal structure of histone K79 methyltransferase Dot1p from yeast | x-ray diffraction | A, B, C | — | — |
| 1U2Z | Crystal structure of histone K79 methyltransferase DOT1P from yeast | x-ray diffraction | A, B, C | — | — |
| 7K6P | Active state Dot1 bound to the unacetylated H4 nucleosome | electron microscopy | K | SAM | 6 (best 0.83) |
| 7K6P | Active state DOT1 bound to the unacetylated H4 nucleosome | electron microscopy | K | — | — |
| 7K6Q | Active state DOT1 bound to the H4K16AC nucleosome | electron microscopy | K | — | — |
| Q04089 | AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase, H3 lysine-79 specific… | predicted | A | — | — |
Ligands
- SAM · S-adenosylmethionine · in 1 record
Experiment against prediction
- 1U2Z chain C against the predicted model Q04089: TM-score 0.97, RMSD 0.66 Å
- 1U2Z chain C against the predicted model Q04089: TM-score 0.97, RMSD 0.66 Å
- 7K6P chain K against the predicted model Q04089: TM-score 0.97, RMSD 1.45 Å
- 1U2Z chain B against the predicted model Q04089: TM-score 0.97, RMSD 0.97 Å
- 1U2Z chain B against the predicted model Q04089: TM-score 0.97, RMSD 0.97 Å
- 7K6P chain K against the predicted model Q04089: TM-score 0.97, RMSD 1.45 Å
- 7K6Q chain K against the predicted model Q04089: TM-score 0.96, RMSD 1.50 Å
- 1U2Z chain A against the predicted model Q04089: TM-score 0.96, RMSD 1.21 Å
- 1U2Z chain A against the predicted model Q04089: TM-score 0.96, RMSD 1.21 Å
Elsewhere
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