UniProt Q03862
Probable metalloprotease ARX1 (Q03862)
Probable metalloprotease ARX1 (UniProt Q03862), EC 3.-.-.-: 16 experimental structures and 1 predicted model on GenesisL1, 12 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q03862
- Protein
- Probable metalloprotease ARX1
- EC
- 3.-.-.-
- Experimental structures
- 16
- Predicted models
- 1
- Pockets
- 12 · 10 records with a druggable one
Structures
17 records of Q03862 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3JCT | Cryo-em structure of eukaryotic pre-60S ribosomal subunits | electron microscopy | 4 | — | 1 (best 0.88) |
| 4V7F | Arx1 pre-60S particle. | electron microscopy | l | — | 1 (best 0.74) |
| 4V7F | ARX1 pre-60S particle. | electron microscopy | l | — | 1 (best 0.74) |
| 4V8T | Cryo-EM Structure of the 60S Ribosomal Subunit in Complex with Arx1 and Rei1 | electron microscopy | t | — | — |
| 5JCS | Cryo-EM structure of the RIX1-REA1 pre-60S particle | electron microscopy | u | — | — |
| 6FT6 | Structure of the Nop53 pre-60S particle bound to the exosome nuclear cofactors | electron microscopy | 4 | — | 1 (best 0.86) |
| 6M62 | Cryo-Em structure of eukaryotic pre-60S ribosome subunit from Saccharomyces cerevisiae rpf2 delta… | electron microscopy | 4 | — | 2 (best 0.85) |
| 6RZZ | Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles | electron microscopy | r | — | — |
| 6YLG | Rix1-Rea1 pre-60S particle - 60S core, body 1 (rigid body refinement) | electron microscopy | 4 | — | 1 (best 0.86) |
| 6YLH | Rix1-Rea1 pre-60S particle - full composite structure | electron microscopy | 4 | — | — |
| 7UOO | Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state | electron microscopy | 4 | — | — |
| 7UQB | Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state from a SPB1-D52A… | electron microscopy | 4 | — | 1 (best 0.88) |
| 7UQZ | Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state from a SPB1 D52A strain | electron microscopy | 4 | — | 2 (best 0.88) |
| 7V08 | Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state from a Spb1 D52A… | electron microscopy | 4 | — | 1 (best 0.85) |
| 7Z34 | Structure of pre-60S particle bound to DRG1(AFG2). | electron microscopy | 4 | — | 1 (best 0.86) |
| 8HFR | NPC-trapped pre-60S particle | electron microscopy | pT | — | — |
| Q03862 | AlphaFold monomer V2.0 prediction for probable metalloprotease ARX1 (Q03862) | predicted | A | — | — |
Experiment against prediction
- 7UQZ chain 4 against the predicted model Q03862: TM-score 0.97, RMSD 1.51 Å
- 7UQB chain 4 against the predicted model Q03862: TM-score 0.97, RMSD 1.52 Å
- 7UOO chain 4 against the predicted model Q03862: TM-score 0.97, RMSD 1.53 Å
- 7V08 chain 4 against the predicted model Q03862: TM-score 0.97, RMSD 1.53 Å
- 6FT6 chain 4 against the predicted model Q03862: TM-score 0.97, RMSD 1.47 Å
- 3JCT chain 4 against the predicted model Q03862: TM-score 0.97, RMSD 1.49 Å
- 6YLG chain 4 against the predicted model Q03862: TM-score 0.97, RMSD 1.53 Å
- 6YLH chain 4 against the predicted model Q03862: TM-score 0.97, RMSD 1.53 Å
- 6RZZ chain r against the predicted model Q03862: TM-score 0.96, RMSD 1.68 Å
- 6M62 chain 4 against the predicted model Q03862: TM-score 0.96, RMSD 1.70 Å
Elsewhere
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