UniProt Q02252
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (Q02252)
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (UniProt Q02252), EC 1.2.1.27: 5 experimental structures and 1 predicted model on GenesisL1, 90 pockets. Binding sites, druggability and…
- UniProt
- Q02252
- Protein
- Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating]…
- EC
- 1.2.1.27
- Experimental structures
- 5
- Predicted models
- 1
- Pockets
- 90 · 6 records with a druggable one
Structures
6 records of Q02252 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8XXQ | Structural of methylmalonate semialdehyde dehydrogenase ALDH6A1 | electron microscopy | A, B, C, D | — | 18 (best 0.87) |
| 9IZU | Cryo-EM structure of ALDH6A1-P62S | electron microscopy | C, D | — | 9 (best 0.76) |
| 9IZV | Cryo-EM structure of ALDH6A1-Y172H & R535C | electron microscopy | A, B, C, D | — | 20 (best 0.81) |
| 9IZW | Cryo-EM structure of ALDH6A1-S262Y | electron microscopy | A, B, C, D | — | 20 (best 0.84) |
| 9IZX | Cryo-EM structure of ALDH6A1-G446R | electron microscopy | A, B, C, D | — | 20 (best 0.81) |
| Q02252 | AlphaFold monomer V2.0 prediction for methylmalonate-semialdehyde dehydrogenase [acylating]… | predicted | A | — | 3 (best 0.65) |
Experiment against prediction
- 8XXQ chain A against the predicted model Q02252: TM-score 1.00, RMSD 0.43 Å
- 9IZX chain B against the predicted model Q02252: TM-score 0.99, RMSD 0.92 Å
- 9IZX chain A against the predicted model Q02252: TM-score 0.98, RMSD 1.14 Å
- 9IZX chain C against the predicted model Q02252: TM-score 0.98, RMSD 1.15 Å
- 9IZW chain A against the predicted model Q02252: TM-score 0.98, RMSD 1.14 Å
- 9IZV chain A against the predicted model Q02252: TM-score 0.98, RMSD 1.19 Å
- 9IZU chain D against the predicted model Q02252: TM-score 0.98, RMSD 1.27 Å
- 9IZV chain D against the predicted model Q02252: TM-score 0.98, RMSD 1.27 Å
- 9IZV chain B against the predicted model Q02252: TM-score 0.98, RMSD 1.20 Å
- 9IZX chain D against the predicted model Q02252: TM-score 0.98, RMSD 1.32 Å
Elsewhere
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