UniProt Q02083
N-acylethanolamine-hydrolyzing acid amidase (Q02083)
N-acylethanolamine-hydrolyzing acid amidase (UniProt Q02083), EC 3.5.1.60: 4 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 24 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q02083
- Protein
- N-acylethanolamine-hydrolyzing acid amidase
- EC
- 3.5.1.60
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 24 · 2 records with a druggable one
Structures
5 records of Q02083 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6DXW | Human N-acylethanolamine-hydrolyzing acid amidase (NAAA) precursor (C126A) | x-ray diffraction | A, B, C, D | NAG, FUC, CL | 9 (best 0.67) |
| 6DXW | Human N-acylethanolamine-hydrolyzing acid amidase (naaa) precursor (C126A) | x-ray diffraction | A, B, C, D | NAG, FUC, CL | — |
| 6DXX | Human N-acylethanolamine-hydrolyzing acid amidase (NAAA) in complex with non-covalent… | x-ray diffraction | A, B, C, D, E, F | NAG, CL, TON, WTF, SCN | 14 (best 0.78) |
| 6DXX | Human N-acylethanolamine-hydrolyzing acid amidase (naaa) in complex with non-covalent… | x-ray diffraction | A, B, C, D, E, F | NAG, CL, TON, WTF, SCN | — |
| Q02083 | AlphaFold monomer V2.0 prediction for N-acylethanolamine-hydrolyzing acid amidase (Q02083) | predicted | A | — | 1 (best 0.32) |
Ligands
- CL · Chloride ion · in 4 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
- FUC · alpha-L-fucopyranose · in 2 records
- SCN · Thiocyanate ion · in 2 records
- TON · 2-{2-[4-(1,1,3,3-tetramethylbutyl) phenoxy]ethoxy}ethanol · in 2 records
- WTF · [2-(ethylsulfonyl)phenyl][(2S)-4-(6-fluoro-1,3-benzothiazol-2-yl)-2-methylpiperazin-1-yl]methanone · in 2 records
Experiment against prediction
- 6DXW chain A against the predicted model Q02083: TM-score 1.00, RMSD 0.50 Å
- 6DXW chain A against the predicted model Q02083: TM-score 1.00, RMSD 0.50 Å
- 6DXX chain B against the predicted model Q02083: TM-score 0.98, RMSD 0.67 Å
- 6DXX chain B against the predicted model Q02083: TM-score 0.98, RMSD 0.67 Å
- 6DXX chain A against the predicted model Q02083: TM-score 0.90, RMSD 1.59 Å
- 6DXX chain A against the predicted model Q02083: TM-score 0.90, RMSD 1.59 Å
Elsewhere
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