UniProt Q01469
Fatty acid-binding protein 5 (Q01469)
Fatty acid-binding protein 5 (UniProt Q01469): 24 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 29 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q01469
- Protein
- Fatty acid-binding protein 5
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 29 · 10 records with a druggable one
Structures
25 records of Q01469 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1B56 | Human recombinant epidermal fatty acid binding protein | x-ray diffraction | A | — | — |
| 1B56 | Human recombinant epidermal fatty acid binding protein | x-ray diffraction | A | — | — |
| 1JJJ | Solution structure of recombinant human epidermal-type fatty acid binding protein | solution nmr | A | — | — |
| 1JJJ | Solution structure of recombinant human epidermal-type fatty acid binding protein | solution nmr | A | — | — |
| 4AZM | Human epidermal fatty acid-binding protein (FABP5) in complex with the inhibitor BMS-309413 | x-ray diffraction | A, B | — | — |
| 4AZM | Human epidermal fatty acid-binding protein (FABP5) in complex with the inhibitor bms-309413 | x-ray diffraction | A, B | — | — |
| 4AZR | Human epidermal fatty acid-binding protein (FABP5) in complex with the endocannabinoid anandamide | x-ray diffraction | A, B | — | — |
| 4AZR | Human epidermal fatty acid-binding protein (FABP5) in complex with the endocannabinoid anandamide | x-ray diffraction | A, B | — | — |
| 4LKP | Crystal Structure of Apo Human Epidermal Fatty Acid Binding Protein (FABP5) | x-ray diffraction | A | — | — |
| 4LKP | Crystal structure of apo human epidermal fatty acid binding protein (FABP5) | x-ray diffraction | A | — | — |
| 4LKT | Crystal Structure of Human Epidermal Fatty Acid Binding Protein (FABP5) in Complex with Linoleic… | x-ray diffraction | A, B, C, D | — | — |
| 4LKT | Crystal structure of human epidermal fatty acid binding protein (FABP5) in complex with linoleic… | x-ray diffraction | A, B, C, D | — | — |
| 5HZ5 | FABP5 in complex with 6-Chloro-4-phenyl-2-piperidin-1-yl-3-(1H-tetrazol-5-yl)-quinoline | x-ray diffraction | A | SO4, 65X | 1 (best 0.84) |
| 5HZ5 | FABP5 in complex with 6-chloro-4-phenyl-2-piperidin-1-yl-3-(1H- tetrazol-5-yl)-quinoline | x-ray diffraction | A | — | — |
| 5UR9 | Enantiomer-Specific Binding of the Potent Antinociceptive Agent SBFI-26 to Anandamide transporters… | x-ray diffraction | A, B, C, D, E, F, G, H | 8KS, SO4, MYR | 11 (best 0.82) |
| 5UR9 | Enantiomer-specific binding of the potent antinociceptive agent sbfi- 26 to anandamide transporters… | x-ray diffraction | A, B, C, D, E, F, G, H | 8KS, SO4, MYR | — |
| 7FWI | Crystal Structure of human FABP5 in complex with 2-(indole-1-carbonylamino)benzoic acid, i.e.… | x-ray diffraction | A, B, C | NC0, CL | 8 (best 0.83) |
| 7FXD | Crystal Structure of human FABP5 in complex with 2-(indole-1-carbonylamino)benzoic acid, i.e.… | x-ray diffraction | A | NC0 | 1 (best 0.82) |
| 7FY0 | Crystal Structure of human FABP5 in complex with (2R)-1-[(3,5-dichloro-2-phenylphenyl)carbamoyl]pyrr… | x-ray diffraction | A | SO4, UOF | 1 (best 0.84) |
| 7G01 | Crystal Structure of human FABP5 in complex with 6-chloro-4-phenyl-2-piperidin-1-ylquinoline-3-carbo… | x-ray diffraction | A | SO4, 5M7 | 1 (best 0.84) |
| 7G04 | Crystal Structure of human FABP5 in complex with 7-(4-chlorophenyl)-1,2,3,4-tetrahydronaphthalene-1… | x-ray diffraction | A, B | SO4, CL, WXZ | 3 (best 0.85) |
| 7G0B | Crystal Structure of human FABP5 in complex with 7-bromo-1-methyl-5-phenyl-2,3,4,5-tetrahydro-1-benz… | x-ray diffraction | A | SO4, WK0 | 1 (best 0.84) |
| 7G0E | Crystal Structure of human FABP5 in complex with 2-[(3-ethoxycarbonyl-4,5,6,7-tetrahydro-1-benzothio… | x-ray diffraction | A | L8T, SO4, CL | 1 (best 0.84) |
| 7G1Q | Crystal Structure of human FABP5 in complex with (1S,2R)-2-[(5-carbamoyl-3-ethoxycarbonyl-4-methyl-2… | x-ray diffraction | A | SO4, IOV | 1 (best 0.84) |
| Q01469 | AlphaFold monomer V2.0 prediction for fatty acid-binding protein 5 (Q01469) | predicted | A | — | — |
Ligands
- SO4 · Sulfate ion · in 9 records
- CL · Chloride ion · in 3 records
- 8KS · (1S,2S,3S,4S)-3-{[(naphthalen-1-yl)oxy]carbonyl}-2,4-diphenylcyclobutane-1-carboxylic acid · in 2 records
- MYR · Myristic acid · in 2 records
- NC0 · 2-[(2,3-dihydro-1H-indole-1-carbonyl)amino]benzoic acid · in 2 records
- 5M7 · 6-chloranyl-4-phenyl-2-piperidin-1-yl-quinoline-3-carboxylic acid · in 1 record
- 65X · 6-chloro-4-phenyl-2-(piperidin-1-yl)-3-(1H-tetrazol-5-yl)quinoline · in 1 record
- IOV · (1R,2S)-2-{[5-carbamoyl-3-(ethoxycarbonyl)-4-methylthiophen-2-yl]carbamoyl}cyclohexane-1-carboxylic acid · in 1 record
- L8T · 2-{[3-(ethoxycarbonyl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]carbamoyl}cyclopent-1-ene-1-carboxylic acid · in 1 record
- UOF · 1-[(4,6-dichloro[1,1'-biphenyl]-2-yl)carbamoyl]-D-proline · in 1 record
- WK0 · (4S,5S)-7-bromo-1-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-1-benzazepine-4-carboxylic acid · in 1 record
- WXZ · (1R)-7-(4-chlorophenyl)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid · in 1 record
Experiment against prediction
- 7FXD chain A against the predicted model Q01469: TM-score 0.99, RMSD 0.47 Å
- 7FWI chain A against the predicted model Q01469: TM-score 0.98, RMSD 0.54 Å
- 4LKP chain A against the predicted model Q01469: TM-score 0.98, RMSD 0.60 Å
- 4LKP chain A against the predicted model Q01469: TM-score 0.98, RMSD 0.60 Å
- 5HZ5 chain A against the predicted model Q01469: TM-score 0.98, RMSD 0.59 Å
- 5HZ5 chain A against the predicted model Q01469: TM-score 0.98, RMSD 0.59 Å
- 7G04 chain A against the predicted model Q01469: TM-score 0.98, RMSD 0.61 Å
- 7FY0 chain A against the predicted model Q01469: TM-score 0.98, RMSD 0.61 Å
- 4LKT chain C against the predicted model Q01469: TM-score 0.97, RMSD 0.70 Å
- 4LKT chain C against the predicted model Q01469: TM-score 0.97, RMSD 0.70 Å
Elsewhere
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