UniProt Q01064
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Q01064)
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (UniProt Q01064), EC 3.1.4.17: 13 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 45 pockets. Binding sites, druggability and…
- UniProt
- Q01064
- Protein
- Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
- EC
- 3.1.4.17
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 45 · 11 records with a druggable one
Structures
14 records of Q01064 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1TAZ | Catalytic Domain Of Human Phosphodiesterase 1B | x-ray diffraction | A | ZN, MG | 4 (best 0.63) |
| 1TAZ | Catalytic domain of human phosphodiesterase 1B | x-ray diffraction | A | ZN, MG | 4 (best 0.63) |
| 4NPV | Crystal structure of human PDE1B bound to inhibitor 7A… | x-ray diffraction | A | 0NK, MG, ZN | 1 (best 0.69) |
| 4NPV | Crystal structure of human PDE1B bound to inhibitor 7A (6,7,8… | x-ray diffraction | A | 0NK, MG, ZN | 1 (best 0.69) |
| 4NPW | Crystal structure of human PDE1B bound to inhibitor 19A… | x-ray diffraction | A | ZN, MG, 0NY | 3 (best 0.71) |
| 4NPW | Crystal structure of human PDE1B bound to inhibitor 19A (7,8… | x-ray diffraction | A | ZN, MG, 0NY | 3 (best 0.71) |
| 5B25 | Crystal structure of human PDE1B with inhibitor 3 | x-ray diffraction | A, B, C, D | ZN, MG, 4QJ, SO4 | 13 (best 0.83) |
| 5UOY | Crystal structure of human PDE1B catalytic domain in complex with inhibitor 16j… | x-ray diffraction | A | ZN, MG, 8HM | 2 (best 0.73) |
| 5UOY | Crystal structure of human PDE1B catalytic domain in complex with inhibitor 16J… | x-ray diffraction | A | ZN, MG, 8HM | — |
| 5UP0 | Crystal structure of human PDE1B catalytic domain in complex with inhibitor 3… | x-ray diffraction | A | ZN, MG, 8HP | 3 (best 0.71) |
| 5UP0 | Crystal structure of human PDE1B catalytic domain in complex with inhibitor 3… | x-ray diffraction | A | ZN, MG, 8HP | — |
| 5W6E | PDE1b complexed with compound 3S | x-ray diffraction | A | ZN, MG, 0NY | 4 (best 0.71) |
| 5W6E | PDE1B complexed with compound 3S | x-ray diffraction | A | ZN, MG, 0NY | — |
| Q01064 | AlphaFold monomer V2.0 prediction for CALCIUM/CALMODULIN-dependent 3',5'-cyclic nucleotide… | predicted | A | — | 7 (best 0.77) |
Ligands
- MG · Magnesium ion · in 13 records
- ZN · Zinc ion · in 13 records
- 0NY · 7,8-dimethoxy-N-[(2S)-1-(3-methyl-1H-pyrazol-5-yl) propan-2-yl]quinazolin-4-amine · in 4 records
- 0NK · 6,7,8-trimethoxy-N-(pentan-3-yl)quinazolin-4-amine · in 2 records
- 8HM · 6-[(4-methoxyphenyl)methyl]-9-[(oxan-4-yl)methyl]-8,9, 10,11-tetrahydropyrido[4',3':4,5]thieno[3,2-E][1,2, 4]triazolo[1,5-c]pyrimidin-5(6H)-one · in 2 records
- 8HP · 6-[(4-chlorophenyl)methyl]-8,9,10,11-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one · in 2 records
- 4QJ · (11R,15S)-4-{[4-(6-fluoropyridin-2-yl)phenyl]methyl}-8-methyl-5-(phenylamino)-1,3,4,8,10-pentaazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-one · in 1 record
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 5UP0 chain A against the predicted model Q01064: TM-score 1.00, RMSD 0.40 Å
- 5UP0 chain A against the predicted model Q01064: TM-score 1.00, RMSD 0.40 Å
- 5UOY chain A against the predicted model Q01064: TM-score 1.00, RMSD 0.44 Å
- 5UOY chain A against the predicted model Q01064: TM-score 1.00, RMSD 0.44 Å
- 4NPW chain A against the predicted model Q01064: TM-score 0.99, RMSD 0.49 Å
- 4NPW chain A against the predicted model Q01064: TM-score 0.99, RMSD 0.49 Å
- 5W6E chain A against the predicted model Q01064: TM-score 0.99, RMSD 0.50 Å
- 5W6E chain A against the predicted model Q01064: TM-score 0.99, RMSD 0.50 Å
- 4NPV chain A against the predicted model Q01064: TM-score 0.99, RMSD 0.60 Å
- 4NPV chain A against the predicted model Q01064: TM-score 0.99, RMSD 0.60 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.