UniProt Q00560
Interleukin-6 receptor subunit beta (Q00560)
Interleukin-6 receptor subunit beta (UniProt Q00560): 11 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 49 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q00560
- Protein
- Interleukin-6 receptor subunit beta
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 49 · 7 records with a druggable one
Structures
12 records of Q00560 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2HMH | Crystal structure of SOCS3 in complex with gp130(pTyr757) phosphopeptide. | x-ray diffraction | B | — | — |
| 2HMH | Crystal structure of SOCS3 in complex with GP130(PTYR757) phosphopeptide. | x-ray diffraction | B | — | — |
| 4GL9 | Crystal structure of inhibitory protein SOCS3 in complex with JAK2 kinase domain and fragment of… | x-ray diffraction | I, K, J, L | — | — |
| 4GL9 | Crystal structure of inhibitory protein SOCS3 in complex with JAK2 kinase domain and fragment of… | x-ray diffraction | I, K, J, L | — | — |
| 7Z0L | IL-27 signalling complex | electron microscopy | A | NAG | 3 (best 0.56) |
| 7Z0L | Il-27 signalling complex | electron microscopy | A | NAG | 3 (best 0.56) |
| 8QY4 | Structure of interleukin 11 (gp130 P496L mutant). | electron microscopy | C, F | NAG | 13 (best 0.71) |
| 8QY5 | Structure of interleukin 6. | electron microscopy | A, D | NAG | 10 (best 0.76) |
| 8QY6 | Structure of interleukin 6 (gp130 P496L mutant). | electron microscopy | A, D | NAG | 14 (best 0.76) |
| 8V2B | Cryo-EM structure of mouse type II OSM receptor complex: model for full extracellular assembly | electron microscopy | B | NAG | 4 (best 0.51) |
| 8V2C | Cryo-EM structure of mouse type II OSM receptor complex: model for assembly core region | electron microscopy | B | NAG | 2 (best 0.54) |
| Q00560 | AlphaFold monomer V2.0 prediction for interleukin-6 receptor subunit beta (Q00560) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 7 records
Experiment against prediction
- 8V2C chain B against the predicted model Q00560: TM-score 0.98, RMSD 0.76 Å
- 7Z0L chain A against the predicted model Q00560: TM-score 0.98, RMSD 0.90 Å
- 7Z0L chain A against the predicted model Q00560: TM-score 0.98, RMSD 0.90 Å
- 8QY6 chain A against the predicted model Q00560: TM-score 0.97, RMSD 1.48 Å
- 8QY6 chain D against the predicted model Q00560: TM-score 0.97, RMSD 1.48 Å
- 8QY5 chain A against the predicted model Q00560: TM-score 0.97, RMSD 1.50 Å
- 8QY5 chain D against the predicted model Q00560: TM-score 0.97, RMSD 1.50 Å
- 8QY4 chain F against the predicted model Q00560: TM-score 0.96, RMSD 1.69 Å
- 8QY4 chain C against the predicted model Q00560: TM-score 0.96, RMSD 1.69 Å
- 8V2B chain B against the predicted model Q00560: TM-score 0.96, RMSD 1.70 Å
Elsewhere
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