UniProt Q00403
Transcription initiation factor IIB (Q00403)
Transcription initiation factor IIB (UniProt Q00403), EC 2.3.1.48: 47 experimental structures on GenesisL1, 2 ligands bound, 6 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q00403
- Protein
- Transcription initiation factor IIB
- EC
- 2.3.1.48
- Experimental structures
- 47
- Predicted models
- 0
- Ligands
- 2
- Pockets
- 6 · 1 record with a druggable one
Structures
47 records of Q00403 in the MolNFT archive: 47 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1C9B | Crystal structure of a human tbp core domain-human tfiib core domain complex bound to an extended… | x-ray diffraction | A, E, I, M, Q | — | — |
| 1C9B | Crystal structure of a human tbp core domain-human tfiib core domain complex bound to an extended… | x-ray diffraction | A, E, I, M, Q | — | — |
| 1DL6 | Solution structure of human tfiib N-terminal domain | solution nmr | A | — | — |
| 1DL6 | Solution structure of human tfiib N-terminal domain | solution nmr | A | — | — |
| 1RLY | RDC-derived models of the zinc ribbon domain of human general transcription TFIIB (zinc bound… | solution nmr | A | — | — |
| 1RLY | Rdc-derived models of the zinc ribbon domain of human general transcription tfiib (zinc bound… | solution nmr | A | — | — |
| 1RO4 | RDC-derived models of the zinc ribbon domain of human general transcription factor TFIIB (zinc free… | solution nmr | A | — | — |
| 1RO4 | Rdc-derived models of the zinc ribbon domain of human general transcription factor tfiib (zinc free… | solution nmr | A | — | — |
| 1TFB | NMR studies of human general transcription factor tfiib: dynamics and interaction with VP16… | solution nmr | A | — | — |
| 1TFB | NMR studies of human general transcription factor tfiib: dynamics and interaction with VP16… | solution nmr | A | — | — |
| 1VOL | Tfiib (human core DOMAIN)/TBP (A.THALIANA)/TATA element ternary complex | x-ray diffraction | A | — | — |
| 1VOL | Tfiib (human core DOMAIN)/TBP (A.THALIANA)/TATA element ternary complex | x-ray diffraction | A | — | — |
| 2PHG | Model for VP16 binding to TFIIB | solution nmr | A | — | — |
| 2PHG | Model for VP16 binding to tfiib | solution nmr | A | — | — |
| 5IY6 | Human holo-pic in the closed state | electron microscopy | M | — | — |
| 5IY7 | Human holo-pic in the open state | electron microscopy | M | — | — |
| 5IY8 | Human holo-pic in the initial transcribing state | electron microscopy | M | — | — |
| 5IY9 | Human holo-PIC in the initial transcribing state (no IIS) | electron microscopy | M | ZN | — |
| 5IY9 | Human holo-pic in the initial transcribing state (no iis) | electron microscopy | M | — | — |
| 5IYA | Human core-PIC in the closed state | electron microscopy | M | ZN | — |
| 5IYA | Human core-pic in the closed state | electron microscopy | M | — | — |
| 5IYB | Human core-pic in the open state | electron microscopy | M | — | — |
| 5IYC | Human core-pic in the initial transcribing state | electron microscopy | M | — | — |
| 5IYD | Human core-PIC in the initial transcribing state (no IIS) | electron microscopy | M | ZN | — |
| 5IYD | Human core-pic in the initial transcribing state (no iis) | electron microscopy | M | — | — |
| 5WH1 | Apo form of the C-terminal region of human transcription factor iib | x-ray diffraction | A, B, C, D | SO4 | — |
| 6O9L | Human holo-pic in the closed state | electron microscopy | M | ZN | — |
| 7EDX | P53-bound tfiid-based core pic on HDM2 promoter | electron microscopy | R | ZN | — |
| 7EG7 | Tfiid-based core pic on scp promoter | electron microscopy | R | ZN | — |
| 7EG8 | Tfiid-based core pic on puma promoter | electron microscopy | R | ZN | — |
| 7EG9 | Tfiid-based intermediate pic on scp promoter | electron microscopy | R | ZN | — |
| 7EGA | TFIID-based intermediate PIC on PUMA promoter | electron microscopy | R | ZN | — |
| 7EGA | Tfiid-based intermediate pic on puma promoter | electron microscopy | R | ZN | — |
| 7EGC | p53-bound TFIID-based holo PIC on HDM2 promoter | electron microscopy | R | ZN | — |
| 7ENA | TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) | electron microscopy | BA | ZN | — |
| 7ENC | TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) | electron microscopy | BA | ZN | — |
| 7NVR | Human Mediator with RNA Polymerase II Pre-initiation complex | electron microscopy | M | ZN | — |
| 7NVR | Human mediator with RNA polymerase II pre-initiation complex | electron microscopy | M | ZN | — |
| 7NVS | RNA polymerase II core pre-initiation complex with closed promoter DNA in proximal position | electron microscopy | M | ZN | — |
| 7NVT | RNA polymerase II core pre-initiation complex with closed promoter DNA in distal position | electron microscopy | M | ZN | — |
| 7NVU | RNA polymerase II core pre-initiation complex with open promoter DNA | electron microscopy | M | ZN | — |
| 7NVY | RNA polymerase II pre-initiation complex with closed promoter DNA in proximal position | electron microscopy | M | ZN | — |
| 7NVZ | RNA polymerase II pre-initiation complex with closed promoter DNA in distal position | electron microscopy | M | ZN | — |
| 7NW0 | RNA polymerase II pre-initiation complex with open promoter DNA | electron microscopy | M | ZN | — |
| 7ZXE | Structure of SNAPc containing Pol II pre-initiation complex bound to U1 snRNA promoter (OC) | electron microscopy | M | — | 6 (best 0.77) |
| 8BZ1 | RNA polymerase II core pre-initiation complex with the proximal +1 nucleosome (cPIC-Nuc10W) | electron microscopy | M | ZN | — |
| Q00403 | AlphaFold monomer V2.0 prediction for transcription initiation factor iib (Q00403) | — | — | — |
Ligands
Elsewhere
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