UniProt P9WPZ9
N-acetyl-gamma-glutamyl-phosphate reductase (P9WPZ9)
N-acetyl-gamma-glutamyl-phosphate reductase (UniProt P9WPZ9), EC 1.2.1.38: 10 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 53 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P9WPZ9
- Protein
- N-acetyl-gamma-glutamyl-phosphate reductase
- EC
- 1.2.1.38
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 53 · 4 records with a druggable one
Structures
11 records of P9WPZ9 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7NNI | Crystal structure of Mycobacterium tuberculosis ArgC apoenzyme | x-ray diffraction | A, B | — | 7 (best 0.67) |
| 7NNI | Crystal structure of mycobacterium tuberculosis argc apoenzyme | x-ray diffraction | A, B | — | — |
| 7NNQ | Crystal structure of mycobacterium tuberculosis argc in complex with nicotinamide adenine… | x-ray diffraction | A, B, C, D | NAP | — |
| 7NNR | Crystal structure of Mycobacterium tuberculosis ArgC in complex with xanthene-9-carboxylic acid | x-ray diffraction | A, B | UJQ | 6 (best 0.66) |
| 7NNR | Crystal structure of mycobacterium tuberculosis argc in complex with xanthene-9-carboxylic acid | x-ray diffraction | A, B | UJQ | — |
| 7NOT | Crystal structure of Mycobacterium tuberculosis ArgC in complex with nicotinamide adenine… | x-ray diffraction | A, B, C, D, E, F, G, H | MYI, NAP | 20 (best 0.87) |
| 7NOT | Crystal structure of mycobacterium tuberculosis argc in complex with nicotinamide adenine… | x-ray diffraction | A, B, C, D, E, F, G, H | MYI, NAP | — |
| 7NPH | Crystal structure of mycobacterium tuberculosis argc in complex with… | x-ray diffraction | A, B, C, D, E, F, G, H | UKE, PO4 | — |
| 7NPJ | Crystal structure of Mycobacterium tuberculosis ArgC in complex with 6-phenoxy-3-pyridinamine | x-ray diffraction | A, B, C, D, E, F, G, H | UKK | 20 (best 0.87) |
| 7NPJ | Crystal structure of mycobacterium tuberculosis argc in complex with 6-phenoxy-3-pyridinamine | x-ray diffraction | A, B, C, D, E, F, G, H | UKK | — |
| P9WPZ9 | AlphaFold monomer V2.0 prediction for N-acetyl-gamma-glutamyl- phosphate reductase (P9WPZ9) | predicted | A | — | — |
Ligands
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · in 3 records
- MYI · (5-methoxy-1H-indol-3-yl)acetic acid · in 2 records
- UJQ · 9~{H}-xanthene-9-carboxylic acid · in 2 records
- UKK · 6-phenoxy-3-pyridinamine · in 2 records
- PO4 · Phosphate ion · in 1 record
- UKE · 5-methoxy-1,3-benzoxazole-2-carboxylic acid · in 1 record
Experiment against prediction
- 7NPH chain C against the predicted model P9WPZ9: TM-score 1.00, RMSD 0.39 Å
- 7NNQ chain D against the predicted model P9WPZ9: TM-score 1.00, RMSD 0.40 Å
- 7NNQ chain B against the predicted model P9WPZ9: TM-score 1.00, RMSD 0.40 Å
- 7NPJ chain C against the predicted model P9WPZ9: TM-score 1.00, RMSD 0.43 Å
- 7NPJ chain C against the predicted model P9WPZ9: TM-score 1.00, RMSD 0.43 Å
- 7NOT chain B against the predicted model P9WPZ9: TM-score 1.00, RMSD 0.44 Å
- 7NOT chain B against the predicted model P9WPZ9: TM-score 1.00, RMSD 0.44 Å
- 7NOT chain G against the predicted model P9WPZ9: TM-score 1.00, RMSD 0.44 Å
- 7NOT chain G against the predicted model P9WPZ9: TM-score 1.00, RMSD 0.44 Å
- 7NOT chain H against the predicted model P9WPZ9: TM-score 1.00, RMSD 0.44 Å
Elsewhere
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