UniProt P9WPN8
Putative cytochrome P450 126 (P9WPN8)
Putative cytochrome P450 126 (UniProt P9WPN8), EC 1.14.-.-: 8 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 11 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P9WPN8
- Protein
- Putative cytochrome P450 126
- EC
- 1.14.-.-
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 11 · 2 records with a druggable one
Structures
9 records of P9WPN8 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5LI6 | Crystal structure of Mycobacterium tuberculosis CYP126A1 in complex with… | x-ray diffraction | A, B | HEM, 6XF | 8 (best 0.86) |
| 5LI6 | Crystal structure of mycobacterium tuberculosis CYP126A1 in complex with… | x-ray diffraction | A, B | HEM, 6XF | — |
| 5LI7 | Crystal structure of Mycobacterium tuberculosis CYP126A1 in complex with… | x-ray diffraction | A, B | HEM, 6XD | — |
| 5LI7 | Crystal structure of mycobacterium tuberculosis CYP126A1 in complex with… | x-ray diffraction | A, B | HEM, 6XD | — |
| 5LI8 | Crystal structure of Mycobacterium tuberculosis CYP126A1 in complex with ketoconazole | x-ray diffraction | A | HEM, KKK | 3 (best 0.84) |
| 5LI8 | Crystal structure of mycobacterium tuberculosis CYP126A1 in complex with ketoconazole | x-ray diffraction | A | HEM, KKK | — |
| 5LIE | Crystal structure of Mycobacterium tuberculosis CYP126A1 in complex with imidazole | x-ray diffraction | A, B | HEM | — |
| 5LIE | Crystal structure of mycobacterium tuberculosis CYP126A1 in complex with imidazole | x-ray diffraction | A, B | HEM | — |
| P9WPN8 | AlphaFold monomer V2.0 prediction for putative cytochrome P450 126 (P9WPN8) | predicted | A | — | — |
Ligands
- HEM · Protoporphyrin IX containing Fe · in 8 records
- 6XD · 1-(1-adamantyl)-3-(3-imidazol-1-ylpropyl)urea · in 2 records
- 6XF · ~{N}-[[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl]-2-(4-nitrophenyl)-~{N}-propan-2-yl-ethanamide · in 2 records
- KKK · 1-acetyl-4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine · in 2 records
Experiment against prediction
- 5LI7 chain B against the predicted model P9WPN8: TM-score 0.99, RMSD 0.67 Å
- 5LI7 chain B against the predicted model P9WPN8: TM-score 0.99, RMSD 0.67 Å
- 5LI6 chain B against the predicted model P9WPN8: TM-score 0.99, RMSD 0.74 Å
- 5LI6 chain B against the predicted model P9WPN8: TM-score 0.99, RMSD 0.74 Å
- 5LI7 chain A against the predicted model P9WPN8: TM-score 0.99, RMSD 0.74 Å
- 5LI7 chain A against the predicted model P9WPN8: TM-score 0.99, RMSD 0.74 Å
- 5LI6 chain A against the predicted model P9WPN8: TM-score 0.99, RMSD 0.89 Å
- 5LI6 chain A against the predicted model P9WPN8: TM-score 0.99, RMSD 0.89 Å
- 5LIE chain A against the predicted model P9WPN8: TM-score 0.98, RMSD 1.22 Å
- 5LIE chain A against the predicted model P9WPN8: TM-score 0.98, RMSD 1.22 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.