UniProt P9WP53
O-phosphoserine sulfhydrylase (P9WP53)
O-phosphoserine sulfhydrylase (UniProt P9WP53), EC 2.5.1.113: 12 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P9WP53
- Protein
- O-phosphoserine sulfhydrylase
- EC
- 2.5.1.113
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 8 · 1 record with a druggable one
Structures
13 records of P9WP53 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5I6D | Mycobacterium tuberculosis CysM in complex with the Urea-scaffold inhibitor 5… | x-ray diffraction | A, B, C, D | PLP, AU6 | — |
| 5I6D | Mycobacterium tuberculosis cysm in complex with the urea-scaffold inhibitor 5… | x-ray diffraction | A, B, C, D | — | — |
| 5I7H | Mycobacterium tuberculosis CysM in complex with the Urea-scaffold inhibitor 6… | x-ray diffraction | A, B, C, D | 68V, PLP, CL | — |
| 5I7H | Mycobacterium tuberculosis cysm in complex with the urea-scaffold inhibitor 6… | x-ray diffraction | A, B, C, D | — | — |
| 5I7O | Mycobacterium tuberculosis CysM in complex with the Urea-scaffold inhibitor 7… | x-ray diffraction | A, B, C, D | PLP, S16 | — |
| 5I7O | Mycobacterium tuberculosis cysm in complex with the urea-scaffold inhibitor 7… | x-ray diffraction | A, B, C, D | — | — |
| 5I7R | Mycobacterium tuberculosis CysM in complex with the Urea-scaffold inhibitor 2… | x-ray diffraction | B, A | PLP, 68W | — |
| 5I7R | Mycobacterium tuberculosis cysm in complex with the urea-scaffold inhibitor 2… | x-ray diffraction | B, A | — | — |
| 5IW8 | Mycobacterium tuberculosis CysM in complex with the Urea-scaffold inhibitor 4… | x-ray diffraction | A, B | 6EC, NA, PLP | 8 (best 0.84) |
| 5IW8 | Mycobacterium tuberculosis cysm in complex with the urea-scaffold inhibitor 4… | x-ray diffraction | A, B | — | — |
| 5IWC | Mycobacterium tuberculosis CysM in complex with the Urea-scaffold inhibitor 3… | x-ray diffraction | A, B | PLP, 6EQ | — |
| 5IWC | Mycobacterium tuberculosis cysm in complex with the urea-scaffold inhibitor 3… | x-ray diffraction | A, B | — | — |
| P9WP53 | AlphaFold monomer V2.0 prediction for O-phosphoserine sulfhydrylase (P9WP53) | predicted | A | — | — |
Ligands
- PLP · Pyridoxal-5'-phosphate · in 6 records
- 68V · 3-{[(4-bromophenyl)carbamoyl]amino}benzoic acid · in 1 record
- 68W · 3-{[([1,1'-biphenyl]-3-yl)carbamoyl]amino}benzoic acid · in 1 record
- 6EC · 5-{[([1,1'-biphenyl]-3-yl)carbamoyl]amino}-2-hydroxybenzoic acid · in 1 record
- 6EQ · 4-{[([1,1'-biphenyl]-3-yl)carbamoyl]amino}-2-hydroxybenzoic acid · in 1 record
- AU6 · 3-{[(4-methylphenyl)carbamoyl]amino}benzoic acid · in 1 record
- CL · Chloride ion · in 1 record
- NA · Sodium ion · in 1 record
- S16 · 3-{[(4-chlorophenyl)carbamoyl]amino}benzoic acid · in 1 record
Experiment against prediction
- 5I7H chain C against the predicted model P9WP53: TM-score 0.99, RMSD 0.61 Å
- 5I7H chain C against the predicted model P9WP53: TM-score 0.99, RMSD 0.61 Å
- 5I7O chain C against the predicted model P9WP53: TM-score 0.99, RMSD 0.66 Å
- 5I7O chain C against the predicted model P9WP53: TM-score 0.99, RMSD 0.66 Å
- 5I7H chain A against the predicted model P9WP53: TM-score 0.99, RMSD 0.68 Å
- 5I7H chain A against the predicted model P9WP53: TM-score 0.99, RMSD 0.68 Å
- 5I7O chain A against the predicted model P9WP53: TM-score 0.99, RMSD 0.72 Å
- 5I7O chain A against the predicted model P9WP53: TM-score 0.99, RMSD 0.72 Å
- 5I6D chain C against the predicted model P9WP53: TM-score 0.99, RMSD 0.76 Å
- 5I6D chain C against the predicted model P9WP53: TM-score 0.99, RMSD 0.76 Å
Elsewhere
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