UniProt P9WKI7
Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase (P9WKI7)
Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase (UniProt P9WKI7), EC 1.1.1.205: 15 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 37 pockets. Binding sites…
- UniProt
- P9WKI7
- Protein
- Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase
- EC
- 1.1.1.205
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 37 · 7 records with a druggable one
Structures
16 records of P9WKI7 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4ZQM | Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from… | x-ray diffraction | A | XMP, NAD | 1 (best 0.75) |
| 4ZQM | Crystal structure of the catalytic domain of the inosine monophosphate dehydrogenase from… | x-ray diffraction | A | — | — |
| 4ZQN | Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from… | x-ray diffraction | A | IMP, 4QO | 4 (best 0.74) |
| 4ZQN | Crystal structure of the catalytic domain of the inosine monophosphate dehydrogenase from… | x-ray diffraction | A | — | — |
| 4ZQO | Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from… | x-ray diffraction | A | IMP, Q67, K | 4 (best 0.76) |
| 4ZQO | Crystal structure of the catalytic domain of the inosine monophosphate dehydrogenase from… | x-ray diffraction | A | — | — |
| 4ZQP | Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from… | x-ray diffraction | A | — | — |
| 4ZQP | Crystal structure of the catalytic domain of the inosine monophosphate dehydrogenase from… | x-ray diffraction | A | — | — |
| 4ZQR | Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from… | x-ray diffraction | A, B, C, D | PO4, K | 20 (best 0.83) |
| 4ZQR | Crystal structure of the catalytic domain of the inosine monophosphate dehydrogenase from… | x-ray diffraction | A, B, C, D | — | — |
| 5UPU | Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from… | x-ray diffraction | A | IMP, 6Q9 | 2 (best 0.72) |
| 5UPU | Crystal structure of the catalytic domain of the inosine monophosphate dehydrogenase from… | x-ray diffraction | A | IMP, 6Q9 | — |
| 5UPV | Crystal structure of the catalytic domain of the inosine monophosphate dehydrogenase from… | x-ray diffraction | A | IMP, 8KV | — |
| 9DC8 | Mtb GuaB dCBS in complex with inhibitor G1 | x-ray diffraction | A | IMP, VOA, SO4 | 3 (best 0.75) |
| 9DC9 | Mtb GuaB dCBS in complex with inhibitor compound 5 | x-ray diffraction | A | IMP, A1A3K | 3 (best 0.76) |
| P9WKI7 | AlphaFold monomer V2.0 prediction for inosine-5'-monophosphate dehydrogenase (P9WKI7) | predicted | A | — | — |
Ligands
- IMP · Inosinic acid · in 7 records
- 6Q9 · ~{N}-(2~{H}-indazol-6-yl)-3,5-dimethyl-1~{H}-pyrazole-4-sulfonamide · in 2 records
- K · Potassium ion · in 2 records
- 4QO · 2-chloro-N,N-dimethyl-5-[({2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl}carbamoyl)amino]benzamide · in 1 record
- 8KV · N-{(1S)-1-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]ethyl}-N'-phenylurea · in 1 record
- A1A3K · (3P)-3-(4-chloro-1H-imidazol-2-yl)-5-[(1R)-1-{[(3M)-3-(1H-pyrazol-5-yl)phenyl]oxy}ethyl]pyridine · in 1 record
- NAD · Nicotinamide-adenine-dinucleotide · in 1 record
- PO4 · Phosphate ion · in 1 record
- Q67 · N~2~-(2,3-dichlorophenyl)-N-[2-(pyridin-4-yl)-1,3-benzoxazol-5-yl]-L-alaninamide · in 1 record
- SO4 · Sulfate ion · in 1 record
- VOA · N-(6-chloropyridin-3-yl)-N~2~-(1,4-dihydro-2H-pyrano[3,4-c]quinolin-9-yl)-L-alaninamide · in 1 record
- XMP · Xanthosine-5'-monophosphate · in 1 record
Experiment against prediction
- 4ZQP chain A against the predicted model P9WKI7: TM-score 0.99, RMSD 0.66 Å
- 4ZQP chain A against the predicted model P9WKI7: TM-score 0.99, RMSD 0.66 Å
- 4ZQR chain D against the predicted model P9WKI7: TM-score 0.99, RMSD 0.84 Å
- 4ZQR chain B against the predicted model P9WKI7: TM-score 0.99, RMSD 0.85 Å
- 4ZQN chain A against the predicted model P9WKI7: TM-score 0.99, RMSD 0.85 Å
- 4ZQN chain A against the predicted model P9WKI7: TM-score 0.99, RMSD 0.85 Å
- 4ZQR chain C against the predicted model P9WKI7: TM-score 0.99, RMSD 0.89 Å
- 4ZQR chain C against the predicted model P9WKI7: TM-score 0.99, RMSD 0.89 Å
- 4ZQM chain A against the predicted model P9WKI7: TM-score 0.99, RMSD 0.86 Å
- 4ZQM chain A against the predicted model P9WKI7: TM-score 0.99, RMSD 0.86 Å
Elsewhere
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