UniProt P9WGY8
DNA-directed RNA polymerase subunit beta (P9WGY8)
DNA-directed RNA polymerase subunit beta (UniProt P9WGY8), EC 2.7.7.6: 7 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 52 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P9WGY8
- Protein
- DNA-directed RNA polymerase subunit beta
- EC
- 2.7.7.6
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 52 · 3 records with a druggable one
Structures
8 records of P9WGY8 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6TYE | Crystal structure of MTB sigma L transcription initiation complex with 5 nt long RNA primer | x-ray diffraction | C | — | — |
| 6TYE | Crystal structure of mtb sigma L transcription initiation complex with 5 nt long RNA primer | x-ray diffraction | C | — | — |
| 6TYF | Crystal structure of MTB sigma L transcription initiation complex with 6 nt long RNA primer | x-ray diffraction | C | — | 16 (best 0.85) |
| 6TYF | Crystal structure of mtb sigma L transcription initiation complex with 6 nt long RNA primer | x-ray diffraction | C | — | — |
| 6TYG | Crystal structure of mtb sigma L transcription initiation complex with 9 nt long RNA primer | x-ray diffraction | C | — | — |
| 7RWI | Mycobacterium tuberculosis RNA polymerase sigma L holoenzyme open promoter complex containing… | x-ray diffraction | C | 7US | — |
| 7U22 | Mycobacterium tuberculosis RNA polymerase sigma A holoenzyme open promoter complex containing UMN-7 | x-ray diffraction | C | KYO | 16 (best 0.82) |
| P9WGY8 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit beta (P9WGY8) | predicted | A | — | 20 (best 0.74) |
Ligands
- 7US · (3am,9s,10bp,14s,15r,16s,17r,18r,19r,20s,21s,25r)-6,18, 20-trihydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1'-[2-(2-methyl-5-nitro-1H-imidazol-1-yl) ethyl]-5,10,26-trioxo-3,5,9,10-tetrahydrospiro[9,4-(epoxypentadecanoimino)furo[2',3':7,8]naphtho[1,2-d]imidazole-2,4'-piperidin]-16-yl acetate · in 1 record
- KYO · (9S,14S,15R,16S,17R,18R,19R,20S,21S,25R)-5,6,18,20-tetrahydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1'-(2-methylpropyl)-10,26-dioxo-1,3,9,10-tetrahydrospiro[9,4-(epoxypentadecanoimino)furo[2',3':7,8]naphtho[1,2-d]imidazole-2,4'-piperidin]-16-yl benzoate · in 1 record
Experiment against prediction
- 7U22 chain C against the predicted model P9WGY8: TM-score 0.99, RMSD 1.05 Å
- 6TYE chain C against the predicted model P9WGY8: TM-score 0.99, RMSD 1.19 Å
- 6TYE chain C against the predicted model P9WGY8: TM-score 0.99, RMSD 1.19 Å
- 6TYG chain C against the predicted model P9WGY8: TM-score 0.99, RMSD 1.20 Å
- 6TYF chain C against the predicted model P9WGY8: TM-score 0.99, RMSD 1.21 Å
- 6TYF chain C against the predicted model P9WGY8: TM-score 0.99, RMSD 1.21 Å
- 7RWI chain C against the predicted model P9WGY8: TM-score 0.98, RMSD 1.31 Å
Elsewhere
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