UniProt P9WG49
DNA topoisomerase 1 (P9WG49)
DNA topoisomerase 1 (UniProt P9WG49), EC 5.99.1.2: 5 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 19 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P9WG49
- Protein
- DNA topoisomerase 1
- EC
- 5.99.1.2
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 19 · 3 records with a druggable one
Structures
6 records of P9WG49 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5D5H | Crystal structure of Mycobacterium tuberculosis Topoisomerase I | x-ray diffraction | A | SO4 | 3 (best 0.72) |
| 5D5H | Crystal structure of mycobacterium tuberculosis topoisomerase I | x-ray diffraction | A | — | — |
| 6CQ2 | Crystal structure of mycobacterium tuberculosis topoisomerase I in complex with oligonucleotide… | x-ray diffraction | A | MG, PO4 | — |
| 6CQI | 2.42A Crystal structure of Mycobacterium tuberculosis Topoisomerase I in complex with an… | x-ray diffraction | A | — | 7 (best 0.75) |
| 6CQI | 2.42A crystal structure of mycobacterium tuberculosis topoisomerase I in complex with an… | x-ray diffraction | A | — | — |
| P9WG49 | AlphaFold monomer V2.0 prediction for DNA topoisomerase 1 (P9WG49) | predicted | A | — | 9 (best 0.68) |
Ligands
Experiment against prediction
- 5D5H chain A against the predicted model P9WG49: TM-score 1.00, RMSD 0.64 Å
- 5D5H chain A against the predicted model P9WG49: TM-score 1.00, RMSD 0.64 Å
- 6CQI chain A against the predicted model P9WG49: TM-score 0.94, RMSD 2.40 Å
- 6CQI chain A against the predicted model P9WG49: TM-score 0.94, RMSD 2.40 Å
- 6CQ2 chain A against the predicted model P9WG49: TM-score 0.94, RMSD 2.40 Å
Elsewhere
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