UniProt P9WFY7
tRNA (guanine-N(1)-)-methyltransferase (P9WFY7)
tRNA (guanine-N(1)-)-methyltransferase (UniProt P9WFY7), EC 2.1.1.228: 6 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 9 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P9WFY7
- Protein
- tRNA (guanine-N(1)-)-methyltransferase
- EC
- 2.1.1.228
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 9 · 7 records with a druggable one
Structures
7 records of P9WFY7 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5ZHJ | Crystal structure of TrmD from Mycobacterium tuberculosis in complex with S-adenosyl homocysteine… | x-ray diffraction | A | SAH | 1 (best 0.58) |
| 5ZHJ | Crystal structure of trmd from mycobacterium tuberculosis in complex with S-adenosyl homocysteine… | x-ray diffraction | A | SAH | 1 (best 0.58) |
| 5ZHK | Crystal structure of TrmD from Mycobacterium tuberculosis in complex with active-site inhibitor | x-ray diffraction | A | 9D6 | 1 (best 0.58) |
| 5ZHK | Crystal structure of trmd from mycobacterium tuberculosis in complex with active-site inhibitor | x-ray diffraction | A | 9D6 | 1 (best 0.58) |
| 6JOF | Crystal structure of TrmD from Mycobacterium tuberculosis in complex with active-site inhibitor | x-ray diffraction | A | BWR | 1 (best 0.59) |
| 6JOF | Crystal structure of trmd from mycobacterium tuberculosis in complex with active-site inhibitor | x-ray diffraction | A | BWR | 1 (best 0.59) |
| P9WFY7 | AlphaFold monomer V2.0 prediction for tRNA (guanine-N(1)-)-methyltransferase (P9WFY7) | predicted | A | — | 3 (best 0.59) |
Ligands
- 9D6 · N-[(4-{[cyclohexyl(ethyl)amino]methyl}phenyl)methyl]-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide · in 2 records
- BWR · ~{N}-[[4-[(4-azanylpiperidin-1-yl) methyl]phenyl]methyl]-4-oxidanylidene-3~{H}-thieno[2, 3-d]pyrimidine-5-carboxamide · in 2 records
- SAH · S-adenosyl-L-homocysteine · in 2 records
Experiment against prediction
- 5ZHK chain A against the predicted model P9WFY7: TM-score 0.97, RMSD 0.98 Å
- 5ZHK chain A against the predicted model P9WFY7: TM-score 0.97, RMSD 0.98 Å
- 6JOF chain A against the predicted model P9WFY7: TM-score 0.97, RMSD 0.98 Å
- 6JOF chain A against the predicted model P9WFY7: TM-score 0.97, RMSD 0.98 Å
- 5ZHJ chain A against the predicted model P9WFY7: TM-score 0.96, RMSD 1.25 Å
- 5ZHJ chain A against the predicted model P9WFY7: TM-score 0.96, RMSD 1.25 Å
Elsewhere
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