UniProt P9WFV1
Leucine--tRNA ligase (P9WFV1)
Leucine--tRNA ligase (UniProt P9WFV1), EC 6.1.1.4: 7 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 16 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P9WFV1
- Protein
- Leucine--tRNA ligase
- EC
- 6.1.1.4
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 16 · 8 records with a druggable one
Structures
8 records of P9WFV1 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5AGR | Crystal structure of the LeuRS editing domain of Mycobacterium tuberculosis in complex with the… | x-ray diffraction | A | A52 | 1 (best 0.50) |
| 5AGR | Crystal structure of the leurs editing domain of mycobacterium tuberculosis in complex with the… | x-ray diffraction | A | A52 | 1 (best 0.50) |
| 5AGS | Crystal structure of the LeuRS editing domain of Mycobacterium tuberculosis in complex with the… | x-ray diffraction | A | 38Y | 1 (best 0.54) |
| 5AGS | Crystal structure of the leurs editing domain of mycobacterium tuberculosis in complex with the… | x-ray diffraction | A | 38Y | 1 (best 0.54) |
| 5AGT | Crystal structure of the LeuRS editing domain of Mycobacterium tuberculosis in complex with the… | x-ray diffraction | A | A2H | 1 (best 0.54) |
| 5AGT | Crystal structure of the leurs editing domain of mycobacterium tuberculosis in complex with the… | x-ray diffraction | A | A2H | 1 (best 0.54) |
| 7PQK | Co-Crystal Structure of M. tuberculosis LeuRS in Complex with the Adduct Formed by Prodrug Cmpd1… | x-ray diffraction | A | 81D | 2 (best 0.52) |
| P9WFV1 | AlphaFold monomer V2.0 prediction for leucine--tRNA ligase (P9WFV1) | predicted | A | — | 8 (best 0.70) |
Ligands
- 38Y · 3-(aminomethyl)-4-bromo-7-ethoxybenzo[c][1,2]oxaborol-1(3H)-ol-modified adenosine · in 2 records
- A2H · 4-chloro-3-aminomethyl-7-[ethoxy]-3H-benzo[c][1, 2]oxaborol-1-ol modified adenosine · in 2 records
- A52 · 3-AMINOMETHYL-7-(ETHOXY)-3H-BENZO[C][1,2]OXABOROL-1-OL modified adenosine · in 2 records
- 81D · (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol · in 1 record
Experiment against prediction
- 5AGT chain A against the predicted model P9WFV1: TM-score 0.97, RMSD 1.20 Å
- 5AGT chain A against the predicted model P9WFV1: TM-score 0.97, RMSD 1.20 Å
- 5AGS chain A against the predicted model P9WFV1: TM-score 0.97, RMSD 1.27 Å
- 5AGS chain A against the predicted model P9WFV1: TM-score 0.97, RMSD 1.27 Å
- 7PQK chain A against the predicted model P9WFV1: TM-score 0.96, RMSD 1.44 Å
- 5AGR chain A against the predicted model P9WFV1: TM-score 0.96, RMSD 1.22 Å
- 5AGR chain A against the predicted model P9WFV1: TM-score 0.96, RMSD 1.22 Å
Elsewhere
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