UniProt P97612
Fatty-acid amide hydrolase 1 (P97612)
Fatty-acid amide hydrolase 1 (UniProt P97612), EC 3.5.1.99: 42 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P97612
- Protein
- Fatty-acid amide hydrolase 1
- EC
- 3.5.1.99
- Experimental structures
- 42
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 20 · 1 record with a druggable one
Structures
43 records of P97612 in the MolNFT archive: 42 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1MT5 | Crystal structure of fatty acid amide hydrolase | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | — | — |
| 1MT5 | Crystal structure of fatty acid amide hydrolase | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | — | — |
| 2VYA | Crystal Structure of fatty acid amide hydrolase conjugated with the drug-like inhibitor PF-750 | x-ray diffraction | A, B | — | — |
| 2VYA | Crystal structure of fatty acid amide hydrolase conjugated with the drug-like inhibitor pf-750 | x-ray diffraction | A, B | — | — |
| 2WAP | 3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with the… | x-ray diffraction | A, B | — | — |
| 2WAP | 3D-crystal structure of humanized-rat fatty acid amide hydrolase (faah) conjugated with the… | x-ray diffraction | A, B | — | — |
| 2WJ1 | 3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with… | x-ray diffraction | A, B | — | — |
| 2WJ1 | 3D-crystal structure of humanized-rat fatty acid amide hydrolase (faah) conjugated with… | x-ray diffraction | A, B | — | — |
| 2WJ2 | 3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with… | x-ray diffraction | A, B | — | — |
| 2WJ2 | 3D-crystal structure of humanized-rat fatty acid amide hydrolase (faah) conjugated with… | x-ray diffraction | A, B | — | — |
| 3K7F | Crystal Structure Analysis of a Phenhexyl/Oxazole/Carboxypyridine alpha-Ketoheterocycle Inhibitor… | x-ray diffraction | A, B | — | — |
| 3K7F | Crystal structure analysis of a PHENHEXYL/OXAZOLE/CARBOXYPYRIDINE alpha-ketoheterocycle inhibitor… | x-ray diffraction | A, B | — | — |
| 3K83 | Crystal Structure Analysis of a Biphenyl/Oxazole/Carboxypyridine alpha-ketoheterocycle Inhibitor… | x-ray diffraction | A, B | — | — |
| 3K83 | Crystal structure analysis of a BIPHENYL/OXAZOLE/CARBOXYPYRIDINE alpha-ketoheterocycle inhibitor… | x-ray diffraction | A, B | — | — |
| 3K84 | Crystal Structure Analysis of a Oleyl/Oxadiazole/pyridine Inhibitor Bound to a Humanized Variant of… | x-ray diffraction | A, B | — | — |
| 3K84 | Crystal structure analysis of a OLEYL/OXADIAZOLE/PYRIDINE inhibitor bound to a humanized variant of… | x-ray diffraction | A, B | — | — |
| 3LJ6 | 3D-CRYSTAL STRUCTURE OF HUMANIZED-RAT FATTY ACID AMIDE HYDROLASE (FAAH) CONJUGATED WITH THE… | x-ray diffraction | A, B | — | — |
| 3LJ6 | 3D-crystal structure of humanized-rat fatty acid amide hydrolase (faah) conjugated with the… | x-ray diffraction | A, B | — | — |
| 3LJ7 | 3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with Carbamate… | x-ray diffraction | A, B | — | — |
| 3LJ7 | 3D-crystal structure of humanized-rat fatty acid amide hydrolase (faah) conjugated with carbamate… | x-ray diffraction | A, B | — | — |
| 3OJ8 | Alpha-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational… | x-ray diffraction | A, B | — | — |
| 3OJ8 | Alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational… | x-ray diffraction | A, B | — | — |
| 3PPM | Crystal Structure of a Noncovalently Bound alpha-Ketoheterocycle Inhibitor… | x-ray diffraction | A, B | — | — |
| 3PPM | Crystal structure of a noncovalently bound alpha-ketoheterocycle inhibitor… | x-ray diffraction | A, B | — | — |
| 3PR0 | Crystal Structure of a Covalently Bound alpha-Ketoheterocycle Inhibitor… | x-ray diffraction | A, B | — | — |
| 3PR0 | Crystal structure of a covalently bound alpha-ketoheterocycle inhibitor… | x-ray diffraction | A, B | — | — |
| 3QJ8 | Crystal structure of fatty acid amide hydrolase | x-ray diffraction | A, B | — | — |
| 3QJ8 | Crystal structure of fatty acid amide hydrolase | x-ray diffraction | A, B | — | — |
| 3QJ9 | Crystal structure of fatty acid amide hydrolase with small molecule inhibitor | x-ray diffraction | A, B | — | — |
| 3QJ9 | Crystal structure of fatty acid amide hydrolase with small molecule inhibitor | x-ray diffraction | A, B | — | — |
| 3QK5 | Crystal structure of fatty acid amide hydrolase with small molecule inhibitor | x-ray diffraction | A, B | — | — |
| 3QK5 | Crystal structure of fatty acid amide hydrolase with small molecule inhibitor | x-ray diffraction | A, B | — | — |
| 3QKV | Crystal structure of fatty acid amide hydrolase with small molecule compound | x-ray diffraction | A, B | — | — |
| 3QKV | Crystal structure of fatty acid amide hydrolase with small molecule compound | x-ray diffraction | A, B | — | — |
| 4DO3 | Structure of FAAH with a non-steroidal anti-inflammatory drug | x-ray diffraction | A, B | — | — |
| 4DO3 | Structure of faah with a non-steroidal anti-inflammatory drug | x-ray diffraction | A, B | — | — |
| 4HBP | Crystal Structure of FAAH in complex with inhibitor | x-ray diffraction | A, B | — | — |
| 4HBP | Crystal structure of faah in complex with inhibitor | x-ray diffraction | A, B | — | — |
| 4J5P | Crystal Structure of a Covalently Bound alpha-Ketoheterocycle Inhibitor… | x-ray diffraction | A, B | — | — |
| 4J5P | Crystal structure of a covalently bound alpha-ketoheterocycle inhibitor… | x-ray diffraction | A, B | — | — |
| 6MRG | FAAH bound to non covalent inhibitor | x-ray diffraction | A, B, C, D | JXV | 20 (best 0.87) |
| 6MRG | Faah bound to non covalent inhibitor | x-ray diffraction | A, B, C, D | JXV | — |
| P97612 | AlphaFold monomer V2.0 prediction for fatty-acid amide hydrolase 1 (P97612) | predicted | A | — | — |
Ligands
- JXV · (1R)-2-{[6-(2,3-dihydro-1,4-benzodioxin-6-yl)pyrimidin-4-yl]amino}-1-phenylethan-1-ol · in 2 records
Experiment against prediction
- 3OJ8 chain A against the predicted model P97612: TM-score 1.00, RMSD 0.21 Å
- 3OJ8 chain A against the predicted model P97612: TM-score 1.00, RMSD 0.21 Å
- 3PPM chain A against the predicted model P97612: TM-score 1.00, RMSD 0.21 Å
- 3PPM chain A against the predicted model P97612: TM-score 1.00, RMSD 0.21 Å
- 4DO3 chain A against the predicted model P97612: TM-score 1.00, RMSD 0.23 Å
- 4DO3 chain A against the predicted model P97612: TM-score 1.00, RMSD 0.23 Å
- 2WJ2 chain A against the predicted model P97612: TM-score 1.00, RMSD 0.23 Å
- 2WJ2 chain A against the predicted model P97612: TM-score 1.00, RMSD 0.23 Å
- 3K83 chain A against the predicted model P97612: TM-score 1.00, RMSD 0.24 Å
- 3K83 chain A against the predicted model P97612: TM-score 1.00, RMSD 0.24 Å
Elsewhere
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