UniProt P97481
Endothelial PAS domain-containing protein 1 (P97481)
Endothelial PAS domain-containing protein 1 (UniProt P97481): 13 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 19 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P97481
- Protein
- Endothelial PAS domain-containing protein 1
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 19 · 3 records with a druggable one
Structures
14 records of P97481 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4ZP4 | Crystal structure of the heterodimeric hif-2A:ARNT complex | x-ray diffraction | B, D | — | — |
| 4ZPH | Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex with Proflavine | x-ray diffraction | B, D | — | — |
| 4ZPH | Crystal structure of the heterodimeric hif-2A:ARNT complex with proflavine | x-ray diffraction | B, D | — | — |
| 4ZPK | Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex with HRE DNA | x-ray diffraction | B | — | — |
| 4ZPK | Crystal structure of the heterodimeric hif-2A:ARNT complex with hre DNA | x-ray diffraction | B | — | — |
| 4ZQD | Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex with the Benzoxadiazole Antagonist 0X3 | x-ray diffraction | B, D | — | — |
| 4ZQD | Crystal structure of the heterodimeric hif-2A:ARNT complex with the benzoxadiazole antagonist 0X3 | x-ray diffraction | B, D | — | — |
| 6E3S | Crystal structure of the heterodimeric hif-2 complex with antagonist PT2385 | x-ray diffraction | B | 79A | — |
| 6E3T | Crystal Structure of the Heterodimeric HIF-2 Complex with Antagonist T1001 | x-ray diffraction | B | HO7 | 5 (best 0.79) |
| 6E3T | Crystal structure of the heterodimeric hif-2 complex with antagonist T1001 | x-ray diffraction | B | HO7 | — |
| 6E3U | Crystal Structure of the Heterodimeric HIF-2 Complex with Agonist M1001 | x-ray diffraction | B | HNJ | 8 (best 0.81) |
| 6E3U | Crystal structure of the heterodimeric hif-2 complex with agonist M1001 | x-ray diffraction | B | HNJ | — |
| 7W80 | Crystal Structure of the Heterodimeric HIF-2 in Complex with Antagonist Belzutifan | x-ray diffraction | B | 72Q | 6 (best 0.81) |
| P97481 | AlphaFold monomer V2.0 prediction for endothelial pas domain- containing protein 1 (P97481) | predicted | A | — | — |
Ligands
- HNJ · 3-{[2-(pyrrolidin-1-yl)phenyl]amino}-1H-1lambda~6~,2-benzothiazole-1,1-dione · in 2 records
- HO7 · (6S)-6-(4-bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole · in 2 records
- 72Q · 3-{[(1S,2S,3R)-2,3-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile · in 1 record
- 79A · 3-{[(1S)-2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile · in 1 record
Experiment against prediction
- 4ZPK chain B against the predicted model P97481: TM-score 0.97, RMSD 1.20 Å
- 4ZPK chain B against the predicted model P97481: TM-score 0.97, RMSD 1.20 Å
- 6E3S chain B against the predicted model P97481: TM-score 0.97, RMSD 1.12 Å
- 7W80 chain B against the predicted model P97481: TM-score 0.96, RMSD 1.26 Å
- 6E3U chain B against the predicted model P97481: TM-score 0.96, RMSD 1.28 Å
- 6E3U chain B against the predicted model P97481: TM-score 0.96, RMSD 1.28 Å
- 6E3T chain B against the predicted model P97481: TM-score 0.96, RMSD 1.31 Å
- 6E3T chain B against the predicted model P97481: TM-score 0.96, RMSD 1.31 Å
- 4ZP4 chain D against the predicted model P97481: TM-score 0.96, RMSD 1.46 Å
- 4ZP4 chain B against the predicted model P97481: TM-score 0.95, RMSD 1.46 Å
Elsewhere
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