UniProt P94426
HTH-type transcriptional regulatory protein GabR (P94426)
HTH-type transcriptional regulatory protein GabR (UniProt P94426): 11 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 3 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P94426
- Protein
- HTH-type transcriptional regulatory protein GabR
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 3 · 1 record with a druggable one
Structures
12 records of P94426 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4MGR | The crystal structure of Bacillus subtilis GabR, an autorepressor and PLP- and GABA-dependent… | x-ray diffraction | A, B, C, D | — | — |
| 4MGR | The crystal structure of bacillus subtilis gabr, an autorepressor and plp- and GABA-dependent… | x-ray diffraction | A, B, C, D | — | — |
| 4N0B | Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of GabT | x-ray diffraction | A, B, C, D | — | — |
| 4N0B | Crystal structure of bacillus subtilis gabr, an autorepressor and transcriptional activator of gabt | x-ray diffraction | A, B, C, D | — | — |
| 4TV7 | Crystal structure of Bacillus subtilis GabR at 2.05 Angstroms resolution | x-ray diffraction | A, B, C, D | — | — |
| 4TV7 | Crystal structure of bacillus subtilis gabr at 2.05 ångströms resolution | x-ray diffraction | A, B, C, D | — | — |
| 5T4J | Plp and GABA trigger gabr-mediated transcription regulation in bacillus subsidies via external… | x-ray diffraction | B | PLP, ABU | — |
| 5T4K | PLP and GABA Trigger GabR-Mediated Transcription Regulation in Bacillus subsidies via External… | x-ray diffraction | A | 76U | 3 (best 0.65) |
| 5T4K | Plp and GABA trigger gabr-mediated transcription regulation in bacillus subsidies via external… | x-ray diffraction | A | 76U | — |
| 5X03 | Crystal structure of the C-terminal domain of bacillus subtilis gabr reveals a closed conformation… | x-ray diffraction | A, B | PLP, ABU | — |
| 6UXZ | (S)-4-amino-5-phenoxypentanoate as a selective agonist of the transcription factor gabr | x-ray diffraction | B, C | SO4, QL4 | — |
| P94426 | AlphaFold monomer V2.0 prediction for hth-type transcriptional regulatory protein gabr (P94426) | predicted | A | — | — |
Ligands
- 76U · (4S)-5-fluoro-4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl) amino]pentanoic acid · in 2 records
- ABU · Gamma-amino-butanoic acid · in 2 records
- PLP · Pyridoxal-5'-phosphate · in 2 records
- QL4 · (4S)-4-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy) methyl]pyridin-4-yl}methylidene)amino]-5-phenoxypentanoic acid · in 1 record
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 5T4J chain B against the predicted model P94426: TM-score 0.99, RMSD 0.56 Å
- 6UXZ chain C against the predicted model P94426: TM-score 0.99, RMSD 0.64 Å
- 5T4K chain A against the predicted model P94426: TM-score 0.99, RMSD 0.65 Å
- 5T4K chain A against the predicted model P94426: TM-score 0.99, RMSD 0.65 Å
- 6UXZ chain B against the predicted model P94426: TM-score 0.99, RMSD 0.66 Å
- 4TV7 chain A against the predicted model P94426: TM-score 0.99, RMSD 0.82 Å
- 4TV7 chain A against the predicted model P94426: TM-score 0.99, RMSD 0.82 Å
- 5X03 chain A against the predicted model P94426: TM-score 0.99, RMSD 0.76 Å
- 4MGR chain B against the predicted model P94426: TM-score 0.98, RMSD 1.08 Å
- 4MGR chain B against the predicted model P94426: TM-score 0.98, RMSD 1.08 Å
Elsewhere
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