UniProt P83303
Huwentoxin-IV (P83303)
Huwentoxin-IV (UniProt P83303): 14 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 4 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P83303
- Protein
- Huwentoxin-IV
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 4 · 1 record with a druggable one
Structures
15 records of P83303 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1MB6 | Three dimensional solution structure of huwentoxin-IV by 2D 1H-NMR | solution nmr | A | — | — |
| 1MB6 | Three dimensional solution structure of huwentoxin-IV by 2D 1H-NMR | solution nmr | A | — | — |
| 2M4X | Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by… | solution nmr | A | — | — |
| 2M4X | Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by… | solution nmr | A | — | — |
| 2M4Z | Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by… | solution nmr | A | — | — |
| 2M4Z | Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by… | solution nmr | A | — | — |
| 2M50 | Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by… | solution nmr | A | — | — |
| 2M50 | Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by… | solution nmr | A | — | — |
| 5T3M | Solution structure of a triple mutant of HwTx-IV - a potent blocker of Nav1.7 | solution nmr | A | — | — |
| 5T3M | Solution structure of a triple mutant of hwtx-IV - a potent blocker of NAV1.7 | solution nmr | A | — | — |
| 5TLR | Solution NMR structure of ghwtx-IV | solution nmr | A | NH2 | — |
| 6W6O | NaChBac-Nav1.7VSDII chimera and HWTX-IV complex | electron microscopy | C, E, G, I | — | 4 (best 0.63) |
| 6W6O | Nachbac-NAV1.7VSDII chimera and hwtx-IV complex | electron microscopy | C, E, G, I | — | — |
| 7K48 | Structure of NAVAB/NAV1.7-VS2A chimera trapped in the resting state by tarantula toxin… | electron microscopy | E, F, G, H | — | — |
| P83303 | AlphaFold monomer V2.0 prediction for huwentoxin-IV (P83303) | predicted | A | — | — |
Ligands
- NH2 · Amino group · in 1 record
Experiment against prediction
- 5T3M chain A against the predicted model P83303: TM-score 0.85, RMSD 0.93 Å
- 5T3M chain A against the predicted model P83303: TM-score 0.85, RMSD 0.93 Å
- 1MB6 chain A against the predicted model P83303: TM-score 0.79, RMSD 0.94 Å
- 1MB6 chain A against the predicted model P83303: TM-score 0.79, RMSD 0.94 Å
- 6W6O chain G against the predicted model P83303: TM-score 0.79, RMSD 1.00 Å
- 6W6O chain C against the predicted model P83303: TM-score 0.79, RMSD 1.00 Å
- 6W6O chain C against the predicted model P83303: TM-score 0.79, RMSD 1.00 Å
- 6W6O chain E against the predicted model P83303: TM-score 0.79, RMSD 1.00 Å
- 6W6O chain I against the predicted model P83303: TM-score 0.79, RMSD 1.00 Å
- 7K48 chain E against the predicted model P83303: TM-score 0.74, RMSD 1.17 Å
Elsewhere
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