UniProt P80386
5'-AMP-activated protein kinase subunit beta-1 (P80386)
5'-AMP-activated protein kinase subunit beta-1 (UniProt P80386): 28 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 24 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P80386
- Protein
- 5'-AMP-activated protein kinase subunit beta-1
- Experimental structures
- 28
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 24 · 3 records with a druggable one
Structures
29 records of P80386 in the MolNFT archive: 28 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1Z0M | the glycogen-binding domain of the AMP-activated protein kinase beta1 subunit | x-ray diffraction | A, B, C | — | — |
| 1Z0M | The glycogen-binding domain of the AMP-activated protein kinase BETA1 subunit | x-ray diffraction | A, B, C | — | — |
| 1Z0N | the glycogen-binding domain of the AMP-activated protein kinase | x-ray diffraction | A, B, C | — | — |
| 1Z0N | The glycogen-binding domain of the AMP-activated protein kinase | x-ray diffraction | A, B, C | — | — |
| 4EAG | Co-crystal structure of an chimeric AMPK core with ATP | x-ray diffraction | B | — | — |
| 4EAG | Co-crystal structure of an chimeric ampk core with ATP | x-ray diffraction | B | — | — |
| 4EAK | Co-crystal structure of an AMPK core with ATP | x-ray diffraction | B | — | — |
| 4EAK | Co-crystal structure of an ampk core with ATP | x-ray diffraction | B | — | — |
| 4EAL | Co-crystal of AMPK core with ATP soaked with AMP | x-ray diffraction | B | — | — |
| 4EAL | Co-crystal of ampk core with ATP soaked with AMP | x-ray diffraction | B | — | — |
| 4QFG | Structure of AMPK in complex with STAUROSPORINE inhibitor and in the absence of a synthetic… | x-ray diffraction | B | — | — |
| 4QFG | Structure of ampk in complex with staurosporine inhibitor and in the absence of a synthetic… | x-ray diffraction | B | — | — |
| 4QFR | Structure of AMPK in complex with Cl-A769662 activator and STAUROSPORINE inhibitor | x-ray diffraction | B | — | — |
| 4QFR | Structure of ampk in complex with cl-A769662 activator and staurosporine inhibitor | x-ray diffraction | B | — | — |
| 4QFS | Structure of AMPK in complex with Br2-A769662core activator and STAUROSPORINE inhibitor | x-ray diffraction | B | — | — |
| 4QFS | Structure of ampk in complex with BR2-A769662CORE activator and staurosporine inhibitor | x-ray diffraction | B | — | — |
| 4YEF | beta1 carbohydrate binding module (CBM) of AMP-activated protein kinase (AMPK) in complex with… | x-ray diffraction | A, B, C, D, E, F, G | — | — |
| 4YEF | BETA1 carbohydrate binding module (cbm) of AMP-activated protein kinase (ampk) in complex with… | x-ray diffraction | A, B, C, D, E, F, G | — | — |
| 5KQ5 | AMPK bound to allosteric activator | x-ray diffraction | B | 6VT | 8 (best 0.60) |
| 5KQ5 | Ampk bound to allosteric activator | x-ray diffraction | B | 6VT | — |
| 5T5T | Ampk bound to allosteric activator | x-ray diffraction | B | 75O | — |
| 5UFU | Structure of AMPK bound to activator | x-ray diffraction | B | 85V | 9 (best 0.69) |
| 5UFU | Structure of ampk bound to activator | x-ray diffraction | B | 85V | — |
| 6E4T | Structure of ampk bound to activator | x-ray diffraction | B | HTV, CL | — |
| 6E4U | Structure of AMPK bound to activator | x-ray diffraction | B | HU7 | 7 (best 0.67) |
| 6E4U | Structure of ampk bound to activator | x-ray diffraction | B | HU7 | — |
| 6E4W | Structure of AMPK bound to activator | x-ray diffraction | B | HUG | — |
| 6E4W | Structure of ampk bound to activator | x-ray diffraction | B | HUG | — |
| P80386 | AlphaFold monomer V2.0 prediction for 5'-AMP-activated protein kinase subunit beta-1 (P80386) | predicted | A | — | — |
Ligands
- 6VT · 6-chloranyl-5-[4-(1-oxidanylcyclobutyl)phenyl]-1~{H}-indole-3-carboxylic acid · in 2 records
- 85V · 1,4:3,6-dianhydro-2-O-(6-chloro-5-{4-[1-(hydroxymethyl)cyclopropyl]phenyl}-1H-benzimidazol-2-yl)-D-mannitol · in 2 records
- HU7 · 1-O-{6-chloro-5-[6-(dimethylamino)-2-methoxypyridin-3-yl]-1H-indole-3-carbonyl}-beta-D-glucopyranuronic acid · in 2 records
- HUG · 1-O-(4,6-difluoro-5-{4-[(2S)-oxan-2-yl]phenyl}-1H-indole-3-carbonyl)-beta-D-glucopyranuronic acid · in 2 records
- 75O · 6-chloro-5-[6-(dimethylamino)-2-methoxypyridin-3-yl]-1H-indole-3-carboxylic acid · in 1 record
- CL · Chloride ion · in 1 record
- HTV · 1-O-{6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carbonyl}-beta-D-glucopyranuronic acid · in 1 record
Experiment against prediction
- 1Z0N chain C against the predicted model P80386: TM-score 0.96, RMSD 0.67 Å
- 1Z0N chain C against the predicted model P80386: TM-score 0.96, RMSD 0.67 Å
- 4YEF chain C against the predicted model P80386: TM-score 0.96, RMSD 0.72 Å
- 4YEF chain C against the predicted model P80386: TM-score 0.96, RMSD 0.72 Å
- 1Z0M chain C against the predicted model P80386: TM-score 0.96, RMSD 0.72 Å
- 1Z0M chain C against the predicted model P80386: TM-score 0.96, RMSD 0.72 Å
- 4YEF chain F against the predicted model P80386: TM-score 0.95, RMSD 0.74 Å
- 4YEF chain F against the predicted model P80386: TM-score 0.95, RMSD 0.74 Å
- 1Z0M chain B against the predicted model P80386: TM-score 0.95, RMSD 0.81 Å
- 1Z0M chain B against the predicted model P80386: TM-score 0.95, RMSD 0.81 Å
Elsewhere
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