UniProt P80385
5'-AMP-activated protein kinase subunit gamma-1 (P80385)
5'-AMP-activated protein kinase subunit gamma-1 (UniProt P80385): 40 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 18 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P80385
- Protein
- 5'-AMP-activated protein kinase subunit gamma-1
- Experimental structures
- 40
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 18 · 3 records with a druggable one
Structures
41 records of P80385 in the MolNFT archive: 40 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2V8Q | Crystal structure of the regulatory fragment of mammalian AMPK in complexes with AMP | x-ray diffraction | E | — | — |
| 2V8Q | Crystal structure of the regulatory fragment of mammalian ampk in complexes with AMP | x-ray diffraction | E | — | — |
| 2V92 | Crystal structure of the regulatory fragment of mammalian AMPK in complexes with ATP-AMP | x-ray diffraction | E | — | — |
| 2V92 | Crystal structure of the regulatory fragment of mammalian ampk in complexes with ATP-AMP | x-ray diffraction | E | — | — |
| 2V9J | Crystal structure of the regulatory fragment of mammalian AMPK in complexes with Mg.ATP-AMP | x-ray diffraction | E | — | — |
| 2V9J | Crystal structure of the regulatory fragment of mammalian ampk in complexes with MG.ATP-AMP | x-ray diffraction | E | — | — |
| 2Y8L | Structure of the regulatory fragment of mammalian aMPK in complex with two ADP | x-ray diffraction | E | — | — |
| 2Y8L | Structure of the regulatory fragment of mammalian ampk in complex with two ADP | x-ray diffraction | E | — | — |
| 2Y8Q | Structure of the regulatory fragment of mammalian AMPK in complex with one ADP | x-ray diffraction | E | — | — |
| 2Y8Q | Structure of the regulatory fragment of mammalian ampk in complex with one ADP | x-ray diffraction | E | — | — |
| 2YA3 | Structure of the regulatory fragment of mammalian ampk in complex with coumarin ADP | x-ray diffraction | E | — | — |
| 2YA3 | Structure of the regulatory fragment of mammalian ampk in complex with coumarin ADP | x-ray diffraction | E | — | — |
| 4CFH | Structure of an active form of mammalian AMPK | x-ray diffraction | E | — | — |
| 4CFH | Structure of an active form of mammalian ampk | x-ray diffraction | E | — | — |
| 4EAG | Co-crystal structure of an chimeric AMPK core with ATP | x-ray diffraction | C | — | — |
| 4EAG | Co-crystal structure of an chimeric ampk core with ATP | x-ray diffraction | C | — | — |
| 4EAI | Co-crystal structure of an AMPK core with AMP | x-ray diffraction | C | — | — |
| 4EAI | Co-crystal structure of an ampk core with AMP | x-ray diffraction | C | — | — |
| 4EAJ | Co-crystal of AMPK core with AMP soaked with ATP | x-ray diffraction | C | — | — |
| 4EAJ | Co-crystal of ampk core with AMP soaked with ATP | x-ray diffraction | C | — | — |
| 4EAK | Co-crystal structure of an AMPK core with ATP | x-ray diffraction | C | — | — |
| 4EAK | Co-crystal structure of an ampk core with ATP | x-ray diffraction | C | — | — |
| 4EAL | Co-crystal of AMPK core with ATP soaked with AMP | x-ray diffraction | C | — | — |
| 4EAL | Co-crystal of ampk core with ATP soaked with AMP | x-ray diffraction | C | — | — |
| 4QFG | Structure of AMPK in complex with STAUROSPORINE inhibitor and in the absence of a synthetic… | x-ray diffraction | C | — | — |
| 4QFG | Structure of ampk in complex with staurosporine inhibitor and in the absence of a synthetic… | x-ray diffraction | C | — | — |
| 4QFR | Structure of AMPK in complex with Cl-A769662 activator and STAUROSPORINE inhibitor | x-ray diffraction | C | — | — |
| 4QFR | Structure of ampk in complex with cl-A769662 activator and staurosporine inhibitor | x-ray diffraction | C | — | — |
| 4QFS | Structure of AMPK in complex with Br2-A769662core activator and STAUROSPORINE inhibitor | x-ray diffraction | C | — | — |
| 4QFS | Structure of ampk in complex with BR2-A769662CORE activator and staurosporine inhibitor | x-ray diffraction | C | — | — |
| 5KQ5 | AMPK bound to allosteric activator | x-ray diffraction | C | AMP, ADP, SO4 | 5 (best 0.70) |
| 5KQ5 | Ampk bound to allosteric activator | x-ray diffraction | C | AMP, ADP, SO4 | — |
| 5T5T | Ampk bound to allosteric activator | x-ray diffraction | C | AMP, ADP, SO4 | — |
| 5UFU | Structure of AMPK bound to activator | x-ray diffraction | C | AMP, ADP, SO4 | 8 (best 0.71) |
| 5UFU | Structure of ampk bound to activator | x-ray diffraction | C | AMP, ADP, SO4 | — |
| 6E4T | Structure of ampk bound to activator | x-ray diffraction | C | AMP, ADP, SO4 | — |
| 6E4U | Structure of AMPK bound to activator | x-ray diffraction | C | AMP, ADP, SO4 | 5 (best 0.72) |
| 6E4U | Structure of ampk bound to activator | x-ray diffraction | C | AMP, ADP, SO4 | — |
| 6E4W | Structure of AMPK bound to activator | x-ray diffraction | C | AMP, ADP, SO4 | — |
| 6E4W | Structure of ampk bound to activator | x-ray diffraction | C | AMP, ADP, SO4 | — |
| P80385 | AlphaFold monomer V2.0 prediction for 5'-AMP-activated protein kinase subunit gamma-1 (P80385) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6E4W chain C against the predicted model P80385: TM-score 0.99, RMSD 0.71 Å
- 6E4W chain C against the predicted model P80385: TM-score 0.99, RMSD 0.71 Å
- 5T5T chain C against the predicted model P80385: TM-score 0.99, RMSD 0.76 Å
- 5KQ5 chain C against the predicted model P80385: TM-score 0.99, RMSD 0.76 Å
- 5KQ5 chain C against the predicted model P80385: TM-score 0.99, RMSD 0.76 Å
- 5UFU chain C against the predicted model P80385: TM-score 0.99, RMSD 0.75 Å
- 5UFU chain C against the predicted model P80385: TM-score 0.99, RMSD 0.75 Å
- 4QFR chain C against the predicted model P80385: TM-score 0.99, RMSD 0.78 Å
- 4QFR chain C against the predicted model P80385: TM-score 0.99, RMSD 0.78 Å
- 6E4T chain C against the predicted model P80385: TM-score 0.99, RMSD 0.77 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.