UniProt P80192
Mitogen-activated protein kinase kinase kinase 9 (P80192)
Mitogen-activated protein kinase kinase kinase 9 (UniProt P80192), EC 2.7.11.25: 4 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 18 pockets. Binding sites, druggability and experiment against…
- UniProt
- P80192
- Protein
- Mitogen-activated protein kinase kinase kinase 9
- EC
- 2.7.11.25
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 18 · 5 records with a druggable one
Structures
5 records of P80192 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3DTC | Crystal structure of mixed-lineage kinase MLK1 complexed with compound 16 | x-ray diffraction | A | SO4, VIN | 3 (best 0.66) |
| 3DTC | Crystal structure of mixed-lineage kinase MLK1 complexed with compound 16 | x-ray diffraction | A | SO4, VIN | 3 (best 0.66) |
| 4UY9 | Structure of MLK1 kinase domain with leucine zipper 1 | x-ray diffraction | A, B | — | 3 (best 0.74) |
| 4UY9 | Structure of MLK1 kinase domain with leucine zipper 1 | x-ray diffraction | A, B | — | 3 (best 0.74) |
| P80192 | AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase kinase kinase 9 (P80192) | predicted | A | — | 6 (best 0.77) |
Ligands
Experiment against prediction
- 3DTC chain A against the predicted model P80192: TM-score 0.97, RMSD 1.10 Å
- 3DTC chain A against the predicted model P80192: TM-score 0.97, RMSD 1.10 Å
- 4UY9 chain A against the predicted model P80192: TM-score 0.97, RMSD 1.55 Å
- 4UY9 chain A against the predicted model P80192: TM-score 0.97, RMSD 1.55 Å
- 4UY9 chain B against the predicted model P80192: TM-score 0.96, RMSD 1.74 Å
- 4UY9 chain B against the predicted model P80192: TM-score 0.96, RMSD 1.74 Å
Elsewhere
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