UniProt P80147
4-aminobutyrate aminotransferase, mitochondrial (P80147)
4-aminobutyrate aminotransferase, mitochondrial (UniProt P80147), EC 2.6.1.19, 2.6.1.22: 14 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 20 pockets. Binding sites, druggability and experiment…
- UniProt
- P80147
- Protein
- 4-aminobutyrate aminotransferase, mitochondrial
- EC
- 2.6.1.19, 2.6.1.22
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 20 · 1 record with a druggable one
Structures
15 records of P80147 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1OHV | 4-aminobutyrate-aminotransferase from pig | x-ray diffraction | A, B, C, D | — | — |
| 1OHV | 4-aminobutyrate-aminotransferase from pig | x-ray diffraction | A, B, C, D | — | — |
| 1OHW | 4-AMINOBUTYRATE-AMINOTRANSFERASE inactivated by gamma-vinyl GABA | x-ray diffraction | A, B, C, D | — | — |
| 1OHW | 4-aminobutyrate-aminotransferase inactivated by gamma-vinyl GABA | x-ray diffraction | A, B, C, D | — | — |
| 1OHY | 4-AMINOBUTYRATE-AMINOTRANSFERASE inactivated by gamma-ethynyl GABA | x-ray diffraction | A, B, C, D | — | — |
| 1OHY | 4-aminobutyrate-aminotransferase inactivated by gamma-ethynyl GABA | x-ray diffraction | A, B, C, D | — | — |
| 4Y0D | Gamma-aminobutyric acid aminotransferase inactivated by (1S,3S)-3… | x-ray diffraction | A, B, C, D | — | — |
| 4Y0H | Gamma-aminobutyric acid aminotransferase inactivated by… | x-ray diffraction | A, B, C, D | — | — |
| 4Y0H | Gamma-aminobutyric acid aminotransferase inactivated by (1S,3S)-3… | x-ray diffraction | A, B, C, D | — | — |
| 4Y0I | GABA-aminotransferase inactivated by conformationally-restricted inactivator | x-ray diffraction | A, B, C, D | — | — |
| 4ZSW | Pig brain GABA-at inactivated by (E)-(1S,3S)-3-amino-4- fluoromethylenyl-1-cyclopentanoic acid | x-ray diffraction | A, B, C, D | — | — |
| 4ZSY | Pig Brain GABA-AT inactivated by (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic acid. | x-ray diffraction | A, B, C, D | FES, RW2 | 20 (best 0.77) |
| 4ZSY | Pig brain GABA-at inactivated by (Z)-(1S,3S)-3-amino-4- fluoromethylenyl-1-cyclopentanoic acid. | x-ray diffraction | A, B, C, D | — | — |
| 6B6G | Crystal structure of GABA aminotransferase bound to (S)-3-amino-4… | x-ray diffraction | A, B, C, D | FES, RMT | — |
| P80147 | AlphaFold monomer V2.0 prediction for 4-aminobutyrate aminotransferase, mitochondrial (P80147) | predicted | A | — | — |
Ligands
- FES · Fe2/s2 (inorganic) cluster · in 2 records
- RMT · (3R,4E)-4-[({3-hydroxy-2-methyl-5-[(phosphonooxy) methyl]pyridin-4-yl}methyl)imino]cyclopent-1-ene-1,3-dicarboxylic acid · in 1 record
- RW2 · (1S)-4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]cyclopent-3-ene-1,3-dicarboxylic acid · in 1 record
Experiment against prediction
- 4Y0H chain B against the predicted model P80147: TM-score 1.00, RMSD 0.18 Å
- 4Y0H chain B against the predicted model P80147: TM-score 1.00, RMSD 0.18 Å
- 4ZSY chain B against the predicted model P80147: TM-score 1.00, RMSD 0.18 Å
- 4ZSY chain B against the predicted model P80147: TM-score 1.00, RMSD 0.18 Å
- 4Y0I chain B against the predicted model P80147: TM-score 1.00, RMSD 0.19 Å
- 1OHW chain B against the predicted model P80147: TM-score 1.00, RMSD 0.21 Å
- 1OHW chain B against the predicted model P80147: TM-score 1.00, RMSD 0.21 Å
- 4Y0H chain C against the predicted model P80147: TM-score 1.00, RMSD 0.21 Å
- 4Y0H chain C against the predicted model P80147: TM-score 1.00, RMSD 0.21 Å
- 4ZSW chain B against the predicted model P80147: TM-score 1.00, RMSD 0.21 Å
Elsewhere
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