UniProt P78348
Acid-sensing ion channel 1 (P78348)
Acid-sensing ion channel 1 (UniProt P78348): 8 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 36 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P78348
- Protein
- Acid-sensing ion channel 1
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 36 · 2 records with a druggable one
Structures
9 records of P78348 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6L6I | hASIC1a co-crystallized with Mamb-1 | x-ray diffraction | A, B, C | NAG | — |
| 6L6I | HASIC1A co-crystallized with mamb-1 | x-ray diffraction | A, B, C | NAG | — |
| 6L6N | HASIC1A co-crystallized with nafamostat | x-ray diffraction | A, B, C | NDG, NAG, CL | — |
| 7CFS | Cryo-EM strucutre of human acid-sensing ion channel 1a at pH 8.0 | electron microscopy | A, B, C | NAG, Y01, NA | 20 (best 0.81) |
| 7CFS | Cryo-EM strucutre of human acid-sensing ion channel 1A at pH 8.0 | electron microscopy | A, B, C | NAG, Y01, NA | — |
| 7CFT | Cryo-EM strucutre of human acid-sensing ion channel 1a in complex with snake toxin Mambalgin1 at pH… | electron microscopy | A, B, C | NAG | 16 (best 0.86) |
| 7CFT | Cryo-EM strucutre of human acid-sensing ion channel 1A in complex with snake toxin MAMBALGIN1 at pH… | electron microscopy | A, B, C | NAG | — |
| 7RNN | Human ASIC1A-NB.C1 complex | electron microscopy | D | NAG | — |
| P78348 | AlphaFold monomer V2.0 prediction for acid-sensing ion channel 1 (P78348) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7RNN chain D against the predicted model P78348: TM-score 0.97, RMSD 1.41 Å
- 7CFS chain B against the predicted model P78348: TM-score 0.96, RMSD 1.70 Å
- 7CFS chain B against the predicted model P78348: TM-score 0.96, RMSD 1.70 Å
- 7CFS chain C against the predicted model P78348: TM-score 0.96, RMSD 1.70 Å
- 7CFS chain C against the predicted model P78348: TM-score 0.96, RMSD 1.70 Å
- 7CFS chain A against the predicted model P78348: TM-score 0.96, RMSD 1.70 Å
- 7CFS chain A against the predicted model P78348: TM-score 0.96, RMSD 1.70 Å
- 6L6I chain C against the predicted model P78348: TM-score 0.95, RMSD 1.88 Å
- 6L6I chain C against the predicted model P78348: TM-score 0.95, RMSD 1.88 Å
- 6L6N chain C against the predicted model P78348: TM-score 0.95, RMSD 1.89 Å
Elsewhere
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