UniProt P76129
Oxygen sensor protein DosP (P76129)
Oxygen sensor protein DosP (UniProt P76129), EC 3.1.4.52: 12 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 28 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P76129
- Protein
- Oxygen sensor protein DosP
- EC
- 3.1.4.52
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 28 · 2 records with a druggable one
Structures
13 records of P76129 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1S66 | Crystal structure of heme domain of direct oxygen sensor from E. coli | x-ray diffraction | L, U | — | — |
| 1S66 | Crystal structure of heme domain of direct oxygen sensor from E. COLI | x-ray diffraction | L, U | — | — |
| 1S67 | Crystal structure of heme domain of direct oxygen sensor from E. coli | x-ray diffraction | L, U | — | — |
| 1S67 | Crystal structure of heme domain of direct oxygen sensor from E. COLI | x-ray diffraction | L, U | — | — |
| 1VB6 | Crystal Structure of the heme PAS sensor domain of Ec DOS (oxygen-bound form) | x-ray diffraction | A, B | — | — |
| 1VB6 | Crystal structure of the heme pas sensor domain of ec dos (oxygen- bound form) | x-ray diffraction | A, B | — | — |
| 4HU3 | Crystal structure of EAL domain of the E. coli DosP - monomeric form | x-ray diffraction | A | — | — |
| 4HU3 | Crystal structure of eal domain of the E. COLI dosp - monomeric form | x-ray diffraction | A | — | — |
| 4HU4 | Crystal structure of EAL domain of the E. coli DosP - dimeric form | x-ray diffraction | A, B | — | — |
| 4HU4 | Crystal structure of eal domain of the E. COLI dosp - dimeric form | x-ray diffraction | A, B | — | — |
| 9CE0 | DosP Apo Bent form | electron microscopy | A, B | HEM, OXY | 13 (best 0.77) |
| 9CLO | DosP R97A with c-di-GMP | electron microscopy | A, B | HEM, C2E, MG | 15 (best 0.79) |
| P76129 | AlphaFold monomer V2.0 prediction for oxygen sensor protein dosp (P76129) | predicted | A | — | — |
Ligands
- HEM · Protoporphyrin IX containing Fe · in 2 records
- C2E · 9,9'-[(2r,3r,3as,5s,7ar,9r,10r,10as,12s,14ar)-3,5,10, 12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3, 2-D:3',2'-J][1,3,7,9,2, 8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one) · in 1 record
- MG · Magnesium ion · in 1 record
- OXY · Oxygen molecule · in 1 record
Experiment against prediction
- 1VB6 chain B against the predicted model P76129: TM-score 0.97, RMSD 0.85 Å
- 1VB6 chain B against the predicted model P76129: TM-score 0.97, RMSD 0.85 Å
- 1VB6 chain A against the predicted model P76129: TM-score 0.93, RMSD 1.28 Å
- 1VB6 chain A against the predicted model P76129: TM-score 0.93, RMSD 1.28 Å
- 1S66 chain U against the predicted model P76129: TM-score 0.93, RMSD 1.33 Å
- 1S66 chain U against the predicted model P76129: TM-score 0.93, RMSD 1.33 Å
- 1S67 chain U against the predicted model P76129: TM-score 0.93, RMSD 1.34 Å
- 1S67 chain U against the predicted model P76129: TM-score 0.93, RMSD 1.34 Å
- 4HU4 chain B against the predicted model P76129: TM-score 0.93, RMSD 1.83 Å
- 4HU4 chain B against the predicted model P76129: TM-score 0.93, RMSD 1.83 Å
Elsewhere
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