UniProt P75960

NAD-dependent protein deacylase (P75960)

NAD-dependent protein deacylase (UniProt P75960), EC 3.5.1.-: 19 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 57 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…

UniProt: P75960
Protein: NAD-dependent protein deacylase
EC: 3.5.1.-
Experimental structures: 19
Predicted models: 1
Ligands: 2
Pockets: 57 · 8 records with a druggable one

Structures

20 records of P75960 in the MolNFT archive: 19 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
1S5P	Structure and substrate binding properties of cobB, a Sir2 homolog protein deacetylase from…	x-ray diffraction	A	—	—
1S5P	Structure and substrate binding properties of cobb, a SIR2 homolog protein deacetylase from…	x-ray diffraction	A	—	—
6RXJ	Crystal structure of CobB wt in complex with H4K16-Acetyl peptide	x-ray diffraction	A, B	ZN	—
6RXJ	Crystal structure of cobb wt in complex with H4K16-acetyl peptide	x-ray diffraction	A, B	ZN	—
6RXK	Crystal structure of CobB wt in complex with H4K16-Butyryl peptide	x-ray diffraction	A	ZN	3 (best 0.69)
6RXK	Crystal structure of cobb wt in complex with H4K16-butyryl peptide	x-ray diffraction	A	ZN	—
6RXL	Crystal structure of CobB wt in complex with H4K16-Crotonyl peptide	x-ray diffraction	A	ZN	2 (best 0.70)
6RXL	Crystal structure of cobb wt in complex with H4K16-crotonyl peptide	x-ray diffraction	A	ZN	—
6RXM	Crystal structure of CobB Ac2 (A76G, I131C, V162G) in complex with H4K16-Acetyl peptide	x-ray diffraction	A, B, C, D, E, F	ZN	17 (best 0.82)
6RXM	Crystal structure of cobb AC2 (A76G, I131C, V162G) in complex with H4K16-acetyl peptide	x-ray diffraction	A, B, C, D, E, F	ZN	—
6RXO	Crystal structure of cobb AC2 (A76G, I131C, V162A) in complex with H4K16-buturyl peptide	x-ray diffraction	A, B	ZN	—
6RXP	Crystal structure of CobB Ac2 (A76G,I131C,V162A) in complex with H4K16-Crotonyl peptide	x-ray diffraction	A, B	ZN	7 (best 0.74)
6RXP	Crystal structure of cobb AC2 (A76G,I131C,V162A) in complex with H4K16-crotonyl peptide	x-ray diffraction	A, B	ZN	—
6RXQ	Crystal structure of CobB Ac2 (A76G,I131C,V162A) in complex with H4K16Cr-2'OH-ADPr peptide…	x-ray diffraction	A, B, C, D	KMQ	11 (best 0.81)
6RXQ	Crystal structure of cobb AC2 (A76G,I131C,V162A) in complex with H4K16CR-2'OH-adpr peptide…	x-ray diffraction	A, B, C, D	KMQ	—
6RXR	Crystal structure of CobB Ac2 (A76G, I131C, V162G) in complex with H4K16Cr-2'OH-ADPr peptide…	x-ray diffraction	A, B, C, D	KMQ	12 (best 0.81)
6RXR	Crystal structure of cobb AC2 (A76G, I131C, V162G) in complex with H4K16CR-2'OH-adpr peptide…	x-ray diffraction	A, B, C, D	KMQ	—
6RXS	Crystal structure of CobB Ac3(A76G,Y92A, I131L, V187Y) in complex with H4K16-Acetyl peptide	x-ray diffraction	A	ZN	2 (best 0.66)
6RXS	Crystal structure of cobb AC3(A76G,Y92A, I131L, V187Y) in complex with H4K16-acetyl peptide	x-ray diffraction	A	ZN	—
P75960	AlphaFold monomer V2.0 prediction for NAD-dependent protein deacylase (P75960)	predicted	A	—	3 (best 0.76)

Ligands

ZN · Zinc ion · in 13 records
KMQ · [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{S})-4-[(~{E})-but-2-enoxy]-3,5-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate · in 4 records

Experiment against prediction

6RXJ chain A against the predicted model P75960: TM-score 0.99, RMSD 0.60 Å
6RXJ chain A against the predicted model P75960: TM-score 0.99, RMSD 0.60 Å
1S5P chain A against the predicted model P75960: TM-score 0.99, RMSD 0.60 Å
1S5P chain A against the predicted model P75960: TM-score 0.99, RMSD 0.60 Å
6RXK chain A against the predicted model P75960: TM-score 0.99, RMSD 0.61 Å
6RXK chain A against the predicted model P75960: TM-score 0.99, RMSD 0.61 Å
6RXQ chain B against the predicted model P75960: TM-score 0.99, RMSD 0.65 Å
6RXQ chain B against the predicted model P75960: TM-score 0.99, RMSD 0.65 Å
6RXQ chain A against the predicted model P75960: TM-score 0.99, RMSD 0.65 Å
6RXQ chain A against the predicted model P75960: TM-score 0.99, RMSD 0.65 Å

Elsewhere

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