UniProt P75898
Pyrimidine monooxygenase RutA (P75898)
Pyrimidine monooxygenase RutA (UniProt P75898), EC 1.14.99.46: 7 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P75898
- Protein
- Pyrimidine monooxygenase RutA
- EC
- 1.14.99.46
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 9 · 8 records with a druggable one
Structures
8 records of P75898 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6SGG | Crystal structure of monooxygenase RutA complexed with dioxygen under 1.5 MPa / 15 bars of oxygen… | x-ray diffraction | AAA | SO4, FMN, OXY | 1 (best 0.78) |
| 6SGL | Crystal structure of monooxygenase RutA complexed with Uracil under atmospheric pressure. | x-ray diffraction | AAA | FMN, URA, SO4 | 1 (best 0.74) |
| 6SGM | Crystal structure of monooxygenase RutA complexed with 4-Thiouracil. | x-ray diffraction | AAA | FMN, LDB | 1 (best 0.76) |
| 6SGN | Crystal structure of monooxygenase RutA complexed with 2,4-dimethoxypyrimidine. | x-ray diffraction | AAA | FMN, LD8 | 1 (best 0.76) |
| 6TEE | Crystal structure of monooxygenase RutA under anaerobic conditions. | x-ray diffraction | AAA | FMN | 1 (best 0.77) |
| 6TEF | Crystal structure of monooxygenase RutA complexed with dioxygen under 0.5 MPa / 5 bars of oxygen… | x-ray diffraction | AAA | SO4, FMN, OXY | 1 (best 0.77) |
| 6TEG | Crystal structure of monooxygenase RutA complexed with uracil and dioxygen under 1.5 MPa / 15 bars… | x-ray diffraction | AAA | FMN, URA, SO4, OXY | 1 (best 0.75) |
| P75898 | AlphaFold monomer V2.0 prediction for pyrimidine monooxygenase ruta (P75898) | predicted | A | — | 2 (best 0.85) |
Ligands
Experiment against prediction
- 6SGM chain AAA against the predicted model P75898: TM-score 0.99, RMSD 0.77 Å
- 6SGN chain AAA against the predicted model P75898: TM-score 0.99, RMSD 0.77 Å
- 6SGL chain AAA against the predicted model P75898: TM-score 0.99, RMSD 0.73 Å
- 6TEF chain AAA against the predicted model P75898: TM-score 0.99, RMSD 0.74 Å
- 6SGG chain AAA against the predicted model P75898: TM-score 0.99, RMSD 0.74 Å
- 6TEE chain AAA against the predicted model P75898: TM-score 0.99, RMSD 0.75 Å
- 6TEG chain AAA against the predicted model P75898: TM-score 0.99, RMSD 0.75 Å
Elsewhere
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