UniProt P70158
Acid sphingomyelinase-like phosphodiesterase 3a (P70158)
Acid sphingomyelinase-like phosphodiesterase 3a (UniProt P70158), EC 3.1.4.-: 12 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 6 pockets. Binding sites, druggability and experiment against…
- UniProt
- P70158
- Protein
- Acid sphingomyelinase-like phosphodiesterase 3a
- EC
- 3.1.4.-
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 6 · 2 records with a druggable one
Structures
13 records of P70158 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5FC1 | Murine SMPDL3A in complex with sulfate | x-ray diffraction | A | NAG, ZN, SO4 | — |
| 5FC1 | Murine SMPDL3A in complex with sulfate | x-ray diffraction | A | — | — |
| 5FC5 | Murine SMPDL3A in complex with phosphocholine | x-ray diffraction | A | NAG, ZN, PC | — |
| 5FC5 | Murine SMPDL3A in complex with phosphocholine | x-ray diffraction | A | — | — |
| 5FC6 | Murine SMPDL3A in complex with ADP analog AMPCP | x-ray diffraction | A | NAG, FUC, ZN, AP2 | 3 (best 0.53) |
| 5FC6 | Murine SMPDL3A in complex with ADP analog ampcp | x-ray diffraction | A | — | — |
| 5FC7 | Murine SMPDL3A in complex with sulfate (tetragonal) | x-ray diffraction | A | NAG, FUC, ZN, SO4 | — |
| 5FC7 | Murine SMPDL3A in complex with sulfate (tetragonal) | x-ray diffraction | A | — | — |
| 5FCA | Murine SMPDL3A in presence of excess zinc | x-ray diffraction | A, B | NAG, ZN | — |
| 5FCA | Murine SMPDL3A in presence of excess zinc | x-ray diffraction | A, B | — | — |
| 5FCB | Murine SMPDL3A in complex with AMP | x-ray diffraction | A | NAG, FUC, ZN, AMP | 3 (best 0.52) |
| 5FCB | Murine SMPDL3A in complex with AMP | x-ray diffraction | A | — | — |
| P70158 | AlphaFold monomer V2.0 prediction for acid sphingomyelinase-like phosphodiesterase 3A (P70158) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 6 records
- ZN · Zinc ion · in 6 records
- FUC · alpha-L-fucopyranose · in 3 records
- SO4 · Sulfate ion · in 2 records
- AMP · Adenosine monophosphate · in 1 record
- AP2 · Phosphomethylphosphonic acid adenosyl ester · in 1 record
- PC · Phosphocholine · in 1 record
Experiment against prediction
- 5FCB chain A against the predicted model P70158: TM-score 1.00, RMSD 0.53 Å
- 5FCB chain A against the predicted model P70158: TM-score 1.00, RMSD 0.53 Å
- 5FC1 chain A against the predicted model P70158: TM-score 1.00, RMSD 0.55 Å
- 5FC1 chain A against the predicted model P70158: TM-score 1.00, RMSD 0.55 Å
- 5FC6 chain A against the predicted model P70158: TM-score 1.00, RMSD 0.54 Å
- 5FC6 chain A against the predicted model P70158: TM-score 1.00, RMSD 0.54 Å
- 5FC5 chain A against the predicted model P70158: TM-score 1.00, RMSD 0.54 Å
- 5FC5 chain A against the predicted model P70158: TM-score 1.00, RMSD 0.54 Å
- 5FCA chain B against the predicted model P70158: TM-score 1.00, RMSD 0.57 Å
- 5FCA chain B against the predicted model P70158: TM-score 1.00, RMSD 0.57 Å
Elsewhere
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