UniProt P69740
Hydrogenase-1 small chain (P69740)
Hydrogenase-1 small chain (UniProt P69740), EC 1.12.99.6: 8 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 33 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P69740
- Protein
- Hydrogenase-1 small chain
- EC
- 1.12.99.6
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 33 · 4 records with a druggable one
Structures
9 records of P69740 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5JRD | E. coli Hydrogenase-1 variant P508A | x-ray diffraction | S, T | SF4, F3S, SF3, CL, SO4 | 11 (best 0.82) |
| 5JRD | E. COLI hydrogenase-1 variant P508A | x-ray diffraction | S, T | — | — |
| 5LMM | Structure of E COLI hydrogenase hyd-1 mutant E28Q | x-ray diffraction | S, T | SF4, F3S, SF3, CL, SO4 | — |
| 5LRY | E coli [NiFe] Hydrogenase Hyd-1 mutant E28D | x-ray diffraction | S, T | SF4, F3S, SF3, CL, SO4 | 11 (best 0.83) |
| 5LRY | E COLI [nife] hydrogenase hyd-1 mutant E28D | x-ray diffraction | S, T | SF4, F3S, SF3, CL, SO4 | — |
| 6FPO | High resolution structure of native hydrogenase (hyd-1) | x-ray diffraction | S, T | SF4, F3S, SF3, CL, SO4 | — |
| 6RP2 | Threonine to Cysteine (T225C) variant of E coli hydrogenase-1 | x-ray diffraction | S, T | SF4, F3S, SF3, CL, SO4 | 6 (best 0.83) |
| 6RP2 | Threonine to cysteine (T225C) variant of E COLI hydrogenase-1 | x-ray diffraction | S, T | SF4, F3S, SF3, CL, SO4 | — |
| P69740 | AlphaFold monomer V2.0 prediction for hydrogenase-1 small chain (P69740) | predicted | A | — | 5 (best 0.66) |
Ligands
Experiment against prediction
- 6RP2 chain S against the predicted model P69740: TM-score 1.00, RMSD 0.23 Å
- 6RP2 chain S against the predicted model P69740: TM-score 1.00, RMSD 0.23 Å
- 6FPO chain S against the predicted model P69740: TM-score 1.00, RMSD 0.24 Å
- 5LMM chain S against the predicted model P69740: TM-score 1.00, RMSD 0.26 Å
- 5LRY chain S against the predicted model P69740: TM-score 1.00, RMSD 0.33 Å
- 5LRY chain S against the predicted model P69740: TM-score 1.00, RMSD 0.33 Å
- 5JRD chain S against the predicted model P69740: TM-score 1.00, RMSD 0.34 Å
- 5JRD chain S against the predicted model P69740: TM-score 1.00, RMSD 0.34 Å
Elsewhere
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