UniProt P68106
Peptidyl-prolyl cis-trans isomerase FKBP1B (P68106)
Peptidyl-prolyl cis-trans isomerase FKBP1B (UniProt P68106), EC 2.5.1.18, 5.2.1.8: 43 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 125 pockets. Binding sites, druggability and experiment against…
- UniProt
- P68106
- Protein
- Peptidyl-prolyl cis-trans isomerase FKBP1B
- EC
- 2.5.1.18, 5.2.1.8
- Experimental structures
- 43
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 125 · 27 records with a druggable one
Structures
44 records of P68106 in the MolNFT archive: 43 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1C9H | Crystal structure of FKBP12.6 in complex with rapamycin | x-ray diffraction | A | — | — |
| 1C9H | Crystal structure of FKBP12.6 in complex with rapamycin | x-ray diffraction | A | — | — |
| 4C02 | Crystal structure of human ACVR1 (ALK2) in complex with FKBP12.6 and dorsomorphin | x-ray diffraction | B | — | — |
| 4C02 | Crystal structure of human ACVR1 (ALK2) in complex with FKBP12.6 and dorsomorphin | x-ray diffraction | B | — | — |
| 4IQ2 | P21 crystal form of FKBP12.6 | x-ray diffraction | A, B | — | — |
| 4IQ2 | P21 crystal form of FKBP12.6 | x-ray diffraction | A, B | — | — |
| 4IQC | P3121 crystal form of FKBP12.6 | x-ray diffraction | A, B | — | — |
| 4IQC | P3121 crystal form of FKBP12.6 | x-ray diffraction | A, B | — | — |
| 5HKG | Total chemical synthesis, refolding and crystallographic structure of a fully active immunophilin… | x-ray diffraction | A | RAP, CL | — |
| 5HKG | Total chemical synthesis, refolding and crystallographic structure of a fully active immunophilin… | x-ray diffraction | A | — | — |
| 5T9R | Structure of rabbit RyR1 (Ca2+-only dataset, class 3) | electron microscopy | F, A, H, J | — | 4 (best 0.83) |
| 5TAN | Structure of rabbit RyR1 (Caffeine/ATP/Ca2+ dataset, class 3) | electron microscopy | F, A, H, J | — | 5 (best 0.85) |
| 5TAT | Structure of rabbit RyR1 (Caffeine/ATP/EGTA dataset, class 2) | electron microscopy | F, A, H, J | — | 2 (best 0.81) |
| 5TAV | Structure of rabbit RyR1 (Caffeine/ATP/EGTA dataset, class 4) | electron microscopy | F, A, H, J | — | 3 (best 0.85) |
| 5TAX | Structure of rabbit RyR1 (ryanodine dataset, class 1) | electron microscopy | F, A, H, J | — | 3 (best 0.81) |
| 6JI0 | Structure of RyR2 (F/A/C/Ca2+ dataset) | electron microscopy | B, D, F, H | — | — |
| 6JIY | Structure of RyR2 (F/A/C/H-Ca2+/Ca2+CaM dataset) | electron microscopy | B, E, H, K | — | — |
| 6W1N | Pig Ryanodine Receptor (WT) in 5mM EGTA condition | electron microscopy | A, C, E, G | — | 6 (best 0.85) |
| 6WOU | Cryo-EM structure of recombinant mouse Ryanodine Receptor type 2 mutant R176Q in complex with… | electron microscopy | E, F, G, H | — | — |
| 6X33 | Wt pig RyR1 in complex with apoCaM, EGTA condition (class 3, open) | electron microscopy | A, D, G, J | — | 5 (best 0.86) |
| 6X34 | Pig R615C RYR1 egta (all classes, open) | electron microscopy | A, C, E, G | — | — |
| 6X36 | Pig R615C RyR1 in complex with CaM, EGTA (class 3, closed) | electron microscopy | A, D, G, J | — | 4 (best 0.85) |
| 7JMJ | Functional Pathways of Biomolecules Retrieved from Single-particle Snapshots - Frame 37 - State 5… | electron microscopy | A, F, H, J | — | 5 (best 0.87) |
| 7M6A | High resolution structure of the membrane embedded skeletal muscle ryanodine receptor | electron microscopy | F, H, J, O | — | 4 (best 0.84) |
| 7T65 | Rabbit RyR1 disease mutant Y523S in complex with FKBP12.6 embedded in lipidic nanodisc in the open… | electron microscopy | E, F, G, H | — | 2 (best 0.86) |
| 7U9R | Structure of PKA phosphorylated human RyR2 in the open state | electron microscopy | H, E, F, G | — | 5 (best 0.85) |
| 7UA9 | Structure of dephosphorylated human RyR2 in the open state | electron microscopy | E, F, G, H | — | 5 (best 0.86) |
| 7VMN | Structure of recombinant RyR2 (EGTA dataset, class 2, closed state) | electron microscopy | G, H, I, J | — | — |
| 7VMQ | Structure of recombinant RyR2 (Ca2+ dataset, class 3, open state) | electron microscopy | G, H, I, J | — | — |
| 8DTY | Recombinant mouse RyR2 triple phosphomimetic mutant S2807D/S2813D/S2030D in complex with FKBP12.6… | electron microscopy | E, F, G, H | — | 4 (best 0.88) |
| 8DTZ | Recombinant mouse RyR2 triple phosphonull mutant S2807A/S2813A/S2030A in complex with FKBP12.6 and… | electron microscopy | E, F, G, H | — | 4 (best 0.88) |
| 8DUJ | Global map in C1 of RyR1 particles in complex with ImperaCalcin | electron microscopy | H, B, E, K | — | 3 (best 0.87) |
| 8SEN | Cryo-EM Structure of RyR1 | electron microscopy | E, F, G, H | — | 9 (best 0.85) |
| 8SEO | Cryo-EM Structure of RyR1 + ATP-gamma-S | electron microscopy | E, F, G, H | — | 4 (best 0.83) |
| 8SEP | Cryo-EM Structure of RyR1 + ADP | electron microscopy | E, F, G, H | — | 7 (best 0.83) |
| 8SES | Cryo-EM Structure of RyR1 + Adenine | electron microscopy | E, F, G, H | — | 7 (best 0.83) |
| 8SET | Cryo-EM Structure of RyR1 + cAMP | electron microscopy | E, F, G, H | — | 8 (best 0.83) |
| 8UXE | Structure of PKA phosphorylated human RyR2-R420Q in the closed state in the presence of ARM210 | electron microscopy | E, F, G, H | — | 4 (best 0.77) |
| 8UXI | Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium | electron microscopy | E, F, G, H | — | 5 (best 0.87) |
| 8UXM | Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium and… | electron microscopy | E, F, G, H | — | 4 (best 0.83) |
| 9C1E | Mink RyR3 in closed conformation | electron microscopy | A, C, E, G | — | 4 (best 0.85) |
| 9C1F | Mink RyR3 in open conformation bound to Ca2+/ATP/caffeine | electron microscopy | A, C, E, G | — | 5 (best 0.87) |
| 9CGP | RyR1 disease mutant Y523S with FKBP12.6, nanodisc and inhibitor dantrolene in the absence of… | electron microscopy | E, F, G, H | — | 4 (best 0.83) |
| P68106 | AlphaFold monomer V2.0 prediction for peptidyl-prolyl cis-trans isomerase FKBP1B (P68106) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4C02 chain B against the predicted model P68106: TM-score 0.98, RMSD 0.58 Å
- 4C02 chain B against the predicted model P68106: TM-score 0.98, RMSD 0.58 Å
- 7M6A chain H against the predicted model P68106: TM-score 0.98, RMSD 0.50 Å
- 7M6A chain O against the predicted model P68106: TM-score 0.98, RMSD 0.50 Å
- 7M6A chain F against the predicted model P68106: TM-score 0.98, RMSD 0.50 Å
- 7M6A chain J against the predicted model P68106: TM-score 0.98, RMSD 0.50 Å
- 4IQC chain A against the predicted model P68106: TM-score 0.98, RMSD 0.51 Å
- 4IQC chain A against the predicted model P68106: TM-score 0.98, RMSD 0.51 Å
- 7UA9 chain F against the predicted model P68106: TM-score 0.98, RMSD 0.51 Å
- 7UA9 chain G against the predicted model P68106: TM-score 0.98, RMSD 0.51 Å
Elsewhere
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