UniProt P62943
Peptidyl-prolyl cis-trans isomerase FKBP1A (P62943)
Peptidyl-prolyl cis-trans isomerase FKBP1A (UniProt P62943), EC 5.2.1.8: 18 experimental structures and 1 predicted model on GenesisL1, 97 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P62943
- Protein
- Peptidyl-prolyl cis-trans isomerase FKBP1A
- EC
- 5.2.1.8
- Experimental structures
- 18
- Predicted models
- 1
- Pockets
- 97 · 18 records with a druggable one
Structures
19 records of P62943 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3J8H | Structure of the rabbit ryanodine receptor RyR1 in complex with FKBP12 at 3.8 Angstrom resolution | electron microscopy | B, D, F, H | — | 4 (best 0.83) |
| 5GKY | Structure of RyR1 in a closed state (C1 conformer) | electron microscopy | B, D, F, H | — | 4 (best 0.83) |
| 5GKZ | Structure of RyR1 in a closed state (C3 conformer) | electron microscopy | B, D, F, H | — | 4 (best 0.82) |
| 5GL0 | Structure of RyR1 in a closed state (C4 conformer) | electron microscopy | B, D, F, H | — | 4 (best 0.84) |
| 5GL1 | Structure of RyR1 in an open state | electron microscopy | B, D, F, H | — | 4 (best 0.87) |
| 7TZC | A drug and ATP binding site in type 1 ryanodine receptor | electron microscopy | F, H, J, O | — | 6 (best 0.86) |
| 9E17 | Structure of RyR1 in the primed state in the presence of caffeine (reprocessed/reanalyzed from… | electron microscopy | F, H, J, O | — | 6 (best 0.86) |
| 9E18 | Structure of RyR1 in the primed state in the presence of pentoxifylline | electron microscopy | E, H, G, F | — | 6 (best 0.84) |
| 9E19 | Structure of RyR1 in the open state in the presence of pentoxifylline | electron microscopy | E, H, G, F | — | 4 (best 0.82) |
| 9E1A | Structure of RyR1 in the primed state in the presence of dyphylline | electron microscopy | E, H, G, F | — | 6 (best 0.84) |
| 9E1B | Structure of RyR1 in the open state in the presence of dyphylline | electron microscopy | E, H, G, F | — | 3 (best 0.83) |
| 9E1C | Structure of RyR1 in the primed state in the presence of IBMX | electron microscopy | E, H, G, F | — | 7 (best 0.84) |
| 9E1D | Structure of RyR1 in the primed state in the presence of enprofylline | electron microscopy | E, H, G, F | — | 6 (best 0.84) |
| 9E1E | Structure of RyR1 in the primed state in the presence of uracil | electron microscopy | E, H, G, F | — | 6 (best 0.85) |
| 9E1F | Structure of RyR1 in the primed state in the presence of allopurinol | electron microscopy | E, H, G, F | — | 7 (best 0.85) |
| 9E1G | Structure of RyR1 in the primed state in the presence of oxypurinol | electron microscopy | E, H, G, F | — | 6 (best 0.85) |
| 9E1H | Structure of RyR1 in the primed state in the presence of oxopyricid | electron microscopy | E, H, G, F | — | 7 (best 0.85) |
| 9E1I | Structure of RyR1 in the open state in the presence of oxopyricid | electron microscopy | E, H, G, F | — | 7 (best 0.84) |
| P62943 | AlphaFold monomer V2.0 prediction for peptidyl-prolyl cis-trans isomerase FKBP1A (P62943) | predicted | A | — | — |
Experiment against prediction
- 9E1E chain H against the predicted model P62943: TM-score 0.99, RMSD 0.40 Å
- 9E1E chain E against the predicted model P62943: TM-score 0.99, RMSD 0.40 Å
- 9E1E chain F against the predicted model P62943: TM-score 0.99, RMSD 0.40 Å
- 9E1E chain G against the predicted model P62943: TM-score 0.99, RMSD 0.40 Å
- 9E1F chain E against the predicted model P62943: TM-score 0.99, RMSD 0.41 Å
- 9E1F chain G against the predicted model P62943: TM-score 0.99, RMSD 0.41 Å
- 9E1C chain F against the predicted model P62943: TM-score 0.99, RMSD 0.41 Å
- 9E1C chain H against the predicted model P62943: TM-score 0.99, RMSD 0.41 Å
- 9E1C chain G against the predicted model P62943: TM-score 0.99, RMSD 0.41 Å
- 9E1C chain E against the predicted model P62943: TM-score 0.99, RMSD 0.41 Å
Elsewhere
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