UniProt P62877
E3 ubiquitin-protein ligase RBX1 (P62877)
E3 ubiquitin-protein ligase RBX1 (UniProt P62877), EC 2.3.2.27, 2.3.2.32: 60 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 146 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P62877
- Protein
- E3 ubiquitin-protein ligase RBX1
- EC
- 2.3.2.27, 2.3.2.32, 6.3.2.-
- Experimental structures
- 60
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 146 · 30 records with a druggable one
Structures
61 records of P62877 in the MolNFT archive: 60 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1LDJ | Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex | x-ray diffraction | B | — | — |
| 1LDJ | Structure of the CUL1-RBX1-SKP1-F BOXSKP2 scf ubiquitin ligase complex | x-ray diffraction | B | — | — |
| 1LDK | Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex | x-ray diffraction | C | — | — |
| 1LDK | Structure of the CUL1-RBX1-SKP1-F BOXSKP2 scf ubiquitin ligase complex | x-ray diffraction | C | — | — |
| 1U6G | Crystal Structure of The Cand1-Cul1-Roc1 Complex | x-ray diffraction | B | — | — |
| 1U6G | Crystal structure of the CAND1-CUL1-ROC1 complex | x-ray diffraction | B | — | — |
| 2HYE | Crystal Structure of the DDB1-Cul4A-Rbx1-SV5V Complex | x-ray diffraction | D | — | — |
| 2HYE | Crystal structure of the DDB1-CUL4A-RBX1-SV5V complex | x-ray diffraction | D | — | — |
| 2LGV | Rbx1 | solution nmr | A | — | — |
| 2LGV | RBX1 | solution nmr | A | — | — |
| 3DPL | Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of… | x-ray diffraction | R | — | — |
| 3DPL | Structural insights into NEDD8 activation of cullin-ring ligases: conformational control of… | x-ray diffraction | R | — | — |
| 3DQV | Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of… | x-ray diffraction | R, Y | — | — |
| 3DQV | Structural insights into NEDD8 activation of cullin-ring ligases: conformational control of… | x-ray diffraction | R, Y | — | — |
| 3RTR | A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into… | x-ray diffraction | B, D, F, H | — | — |
| 3RTR | A ring E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into… | x-ray diffraction | B, D, F, H | — | — |
| 4F52 | Structure of a Glomulin-RBX1-CUL1 complex | x-ray diffraction | B, D | — | — |
| 4F52 | Structure of a glomulin-RBX1-CUL1 complex | x-ray diffraction | B, D | — | — |
| 4P5O | Structure of an RBX1-UBC12~NEDD8-CUL1-DCN1 complex: a RING-E3-E2~ubiquitin-like protein-substrate… | x-ray diffraction | B, D | — | — |
| 4P5O | Structure of an RBX1-UBC12~NEDD8-CUL1-DCN1 complex: a ring-E3- E2~UBIQUITIN-like protein-substrate… | x-ray diffraction | B, D | — | — |
| 5N4W | Crystal structure of the Cul2-Rbx1-EloBC-VHL ubiquitin ligase complex | x-ray diffraction | R | ZN | 5 (best 0.77) |
| 5N4W | Crystal structure of the CUL2-RBX1-elobc-vhl ubiquitin ligase complex | x-ray diffraction | R | ZN | — |
| 6TTU | Ubiquitin ligation to substrate by a cullin-ring E3 ligase at 3.7A resolution: NEDD8-CUL1-RBX1… | electron microscopy | R | ZN | — |
| 7B5L | Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly… | electron microscopy | R | ZN | — |
| 7B5L | Ubiquitin ligation to F-box protein substrates by scf-rbr E3-E3 super- assembly… | electron microscopy | R | ZN | — |
| 7B5M | Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly… | electron microscopy | R | ZN | 3 (best 0.62) |
| 7B5M | Ubiquitin ligation to F-box protein substrates by scf-rbr E3-E3 super- assembly… | electron microscopy | R | ZN | — |
| 7B5N | Ubiquitin ligation to F-box protein substrates by scf-rbr E3-E3 super- assembly… | electron microscopy | R | ZN | — |
| 7B5S | Ubiquitin ligation to F-box protein substrates by scf-rbr E3-E3 super- assembly: CUL1-RBX1-ARIH1… | electron microscopy | R | ZN | — |
| 7OKQ | Cryo-EM structure of the DDB1-DCAF1-CUL4A-RBX1 complex | electron microscopy | D, H, L, P | — | — |
| 7PLO | H. sapiens replisome-CUL2/LRR1 complex | electron microscopy | T | ZN | — |
| 7Z8B | Structure of CRL7FBXW8 reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed… | electron microscopy | R | ZN | 5 (best 0.80) |
| 7Z8B | Structure of CRL7FBXW8 reveals coupling with CUL1-RBX1/ROC1 for multi- cullin-ring E3-catalyzed… | electron microscopy | R | ZN | — |
| 7Z8T | CAND1-SCF-SKP2 CAND1 engaged SCF rocked | electron microscopy | R | ZN | 4 (best 0.85) |
| 7Z8V | CAND1-SCF-SKP2 (SKP1deldel) CAND1 engaged SCF rocked | electron microscopy | R | ZN | 4 (best 0.85) |
| 7ZBW | CAND1-SCF-SKP2 CAND1 rolling-2 SCF engaged | electron microscopy | R | — | 3 (best 0.75) |
| 8B3I | CRL4CSA-E2-Ub (state 2) | electron microscopy | R | ZN | 4 (best 0.75) |
| 8CDJ | CAND1 b-hairpin++-SCF-SKP2 CAND1 rolling SCF engaged | electron microscopy | R | — | 3 (best 0.77) |
| 8CDK | CAND1 b-hairpin++-SCF-SKP2 CAND1 partly engaged SCF partly rocked | electron microscopy | R | ZN | 3 (best 0.84) |
| 8H33 | Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 tetrameric complex | electron microscopy | D, K, L, E | ZN | 8 (best 0.83) |
| 8H35 | Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 octameric complex | electron microscopy | E, D, L, K, R, Q, W, X | ZN | 11 (best 0.81) |
| 8H37 | Cryo-EM Structure of the KBTBD2-CUL3-Rbx1-p85a tetrameric complex | electron microscopy | E, D, R, Q | ZN | 8 (best 0.79) |
| 8IJ1 | Protomer 1 and 2 of the asymmetry trimer of the Cul2-Rbx1-EloBC-FEM1B ubiquitin ligase complex | electron microscopy | R | ZN | 3 (best 0.78) |
| 8JAS | Structure of CRL2APPBP2 bound with RxxGPAA degron (tetramer) | electron microscopy | R, V | ZN | 8 (best 0.71) |
| 8JAV | Structure of CRL2APPBP2 bound with the C-degron of MRPL28 (tetramer) | electron microscopy | R, V | ZN | 8 (best 0.69) |
| 8K9I | Structure of CUL3-RBX1-KLHL22 complex without CUL3 NA motif | electron microscopy | R | — | 2 (best 0.57) |
| 8KHP | CULLIN3-KLHL22-RBX1 E3 ligase | electron microscopy | E, F | — | 1 (best 0.75) |
| 8OR0 | CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2 | electron microscopy | B | ZN | 2 (best 0.86) |
| 8OR3 | CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1 | electron microscopy | B | ZN | 4 (best 0.85) |
| 8Q7E | Structure of CUL9-RBX1 ubiquitin E3 ligase complex - hexameric assembly | electron microscopy | C, D, G, H, K, L | — | 8 (best 0.78) |
| 8R5H | Ubiquitin ligation to neosubstrate by a cullin-RING E3 ligase & Cdc34… | electron microscopy | R | ZN | 5 (best 0.82) |
| 8RHZ | Structure of CUL9-RBX1 ubiquitin E3 ligase complex in unneddylated conformation - symmetry expanded… | electron microscopy | C, D | ZN | 6 (best 0.74) |
| 8RWZ | Open non-crosslinked structure Brd4BD2-MZ1-(NEDD8)-CRL2VHL | electron microscopy | R | ZN | 2 (best 0.63) |
| 8RX0 | (NEDD8)-CRL2VHL-MZ1-Brd4BD2-Ub(G76S, K48C)-UBE2R1(C93K, S138C, C191S, C223S)-Ub | electron microscopy | R | ZN | 4 (best 0.72) |
| 8UBU | Cryo-EM structure of dimeric SCF-FBXL17-BACH1BTB E3 ligase complex close conformation | electron microscopy | B, I | — | 3 (best 0.74) |
| 8WQC | cryo-EM structure of neddylated CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CDK5R1 | electron microscopy | F, J | ZN | 7 (best 0.76) |
| 8WQE | Cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CUX1 (conformation 1) | electron microscopy | J, I | ZN | 6 (best 0.74) |
| 8WQF | cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CUX1 (conformation 2) | electron microscopy | I, E | ZN | 7 (best 0.80) |
| 8WQH | cryo-EM structure of neddylated CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89… | electron microscopy | J, B | ZN | 7 (best 0.67) |
| 9JKB | Cryo-EM structure of the CUL1-RBX1-SKP1-FBXO4 SCF ubiquition ligase complex | electron microscopy | R | — | 2 (best 0.73) |
1 record more on the page itself.
Ligands
- ZN · Zinc ion · in 32 records
Experiment against prediction
- 8JAS chain V against the predicted model P62877: TM-score 0.81, RMSD 1.58 Å
- 8JAV chain V against the predicted model P62877: TM-score 0.80, RMSD 1.66 Å
- 8JAS chain R against the predicted model P62877: TM-score 0.79, RMSD 1.94 Å
- 8RX0 chain R against the predicted model P62877: TM-score 0.79, RMSD 1.79 Å
- 7Z8T chain R against the predicted model P62877: TM-score 0.79, RMSD 2.38 Å
- 8OR3 chain B against the predicted model P62877: TM-score 0.79, RMSD 2.43 Å
- 8WQE chain J against the predicted model P62877: TM-score 0.79, RMSD 1.59 Å
- 7Z8V chain R against the predicted model P62877: TM-score 0.78, RMSD 2.40 Å
- 8CDK chain R against the predicted model P62877: TM-score 0.78, RMSD 2.39 Å
- 8JAV chain R against the predicted model P62877: TM-score 0.78, RMSD 2.12 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.