UniProt P62829

60S ribosomal protein L23 (P62829)

60S ribosomal protein L23 (UniProt P62829): 93 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 179 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: P62829
Protein: 60S ribosomal protein L23
Experimental structures: 93
Predicted models: 1
Ligands: 2
Pockets: 179 · 91 records with a druggable one

Structures

94 records of P62829 in the MolNFT archive: 93 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
4UG0	Structure of the human 80S ribosome	electron microscopy	LV	MG	2 (best 0.89)
4V6X	Structure of the human 80S ribosome	electron microscopy	CV	—	2 (best 0.88)
5LKS	Structure-function insights reveal the human ribosome as a cancer target for antibiotics	electron microscopy	LV	MG	1 (best 0.86)
6IP5	Cryo-EM structure of the CMV-stalled human 80S ribosome (Structure ii)	electron microscopy	2P	—	1 (best 0.88)
6IP6	Cryo-EM structure of the CMV-stalled human 80S ribosome with HCV IRES (Structure iii)	electron microscopy	2P	—	2 (best 0.87)
6IP8	Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv)	electron microscopy	2P	—	2 (best 0.88)
6LQM	Cryo-EM structure of a pre-60S ribosomal subunit - state C	electron microscopy	e	MG	2 (best 0.89)
6LSR	Cryo-EM structure of a pre-60S ribosomal subunit - state B	electron microscopy	e	MG	2 (best 0.88)
6LSS	Cryo-EM structure of a pre-60S ribosomal subunit - state preA	electron microscopy	e	MG	2 (best 0.90)
6LU8	Cryo-EM structure of a human pre-60S ribosomal subunit - state A	electron microscopy	e	MG	2 (best 0.88)
6QZP	High-resolution cryo-EM structure of the human 80S ribosome	electron microscopy	LV	MG	2 (best 0.88)
6XA1	Structure of a drug-like compound stalled human translation termination complex	electron microscopy	LV	—	1 (best 0.87)
6Y0G	Structure of human ribosome in classical-PRE state	electron microscopy	LV	—	—
6Y2L	Structure of human ribosome in POST state	electron microscopy	LV	MG	1 (best 0.86)
6Y57	Structure of human ribosome in hybrid-PRE state	electron microscopy	LV	MG	—
6Y6X	Tetracenomycin X bound to the human ribosome	electron microscopy	LV	MG	1 (best 0.88)
6Z6L	Cryo-EM structure of human CCDC124 bound to 80S ribosomes	electron microscopy	LV	MG	2 (best 0.89)
6Z6M	Cryo-EM structure of human 80S ribosomes bound to EBP1, eEF2 and SERBP1	electron microscopy	LV	MG	2 (best 0.88)
6Z6N	Cryo-EM structure of human EBP1-80S ribosomes (focus on EBP1)	electron microscopy	LV	MG	1 (best 0.88)
6ZM7	SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-EBP1 ribosome complex	electron microscopy	LV	MG	2 (best 0.89)
6ZME	SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-eERF1 ribosome complex	electron microscopy	LV	MG	3 (best 0.88)
6ZMI	SARS-CoV-2 Nsp1 bound to the human LYAR-80S ribosome complex	electron microscopy	LV	MG	3 (best 0.88)
6ZMO	SARS-CoV-2 Nsp1 bound to the human LYAR-80S-eEF1a ribosome complex	electron microscopy	LV	MG	3 (best 0.88)
7F5S	human delta-METTL18 60S ribosome	electron microscopy	LV	MG	1 (best 0.88)
7OW7	EIF6-bound large subunit of the human ribosome	electron microscopy	Q	K, MG	2 (best 0.89)
7XNX	High resolution cry-EM structure of the human 80S ribosome from SNORD127+/+ Kasumi-1 cells	electron microscopy	LV	MG	1 (best 0.88)
7XNY	High resolution cry-EM structure of the human 80S ribosome from SNORD127+/- Kasumi-1 cells	electron microscopy	LV	MG	2 (best 0.89)
8A3D	Human mature large subunit of the ribosome with eIF6 and homoharringtonine bound	electron microscopy	P	K, MG	1 (best 0.88)
8FKP	Human nucleolar pre-60S ribosomal subunit (State A1)	electron microscopy	LG	—	2 (best 0.85)
8FKQ	Human nucleolar pre-60S ribosomal subunit (State A2)	electron microscopy	LG	—	2 (best 0.85)
8FKR	Human nucleolar pre-60S ribosomal subunit (State B1)	electron microscopy	LG	—	2 (best 0.86)
8FKS	Human nucleolar pre-60S ribosomal subunit (State B2)	electron microscopy	LG	—	1 (best 0.84)
8FKT	Human nucleolar pre-60S ribosomal subunit (State C1)	electron microscopy	LG	—	1 (best 0.87)
8FKU	Human nucleolar pre-60S ribosomal subunit (State C2)	electron microscopy	LG	—	2 (best 0.87)
8FKV	Human nucleolar pre-60S ribosomal subunit (State D1)	electron microscopy	LG	—	2 (best 0.87)
8FKW	Human nucleolar pre-60S ribosomal subunit (State D2)	electron microscopy	LG	—	1 (best 0.89)
8FKX	Human nucleolar pre-60S ribosomal subunit (State E)	electron microscopy	LG	—	2 (best 0.87)
8FKY	Human nucleolar pre-60S ribosomal subunit (State F)	electron microscopy	LG	—	2 (best 0.87)
8FKZ	Human nucleolar pre-60S ribosomal subunit (State G)	electron microscopy	LG	—	1 (best 0.88)
8FL0	Human nucleolar pre-60S ribosomal subunit (State H)	electron microscopy	LG	—	2 (best 0.88)
8FL2	Human nuclear pre-60S ribosomal subunit (State I1)	electron microscopy	LG	—	3 (best 0.88)
8FL3	Human nuclear pre-60S ribosomal subunit (State I2)	electron microscopy	LG	—	3 (best 0.90)
8FL4	Human nuclear pre-60S ribosomal subunit (State I3)	electron microscopy	LG	—	2 (best 0.88)
8FL7	Human nuclear pre-60S ribosomal subunit (State J2)	electron microscopy	LG	MG	4 (best 0.89)
8FL9	Human nuclear pre-60S ribosomal subunit (State J3)	electron microscopy	LG	MG	3 (best 0.88)
8FLA	Human nuclear pre-60S ribosomal subunit (State K1)	electron microscopy	LG	MG	3 (best 0.89)
8FLB	Human nuclear pre-60S ribosomal subunit (State K2)	electron microscopy	LG	MG	4 (best 0.88)
8FLC	Human nuclear pre-60S ribosomal subunit (State K3)	electron microscopy	LG	MG	3 (best 0.88)
8FLD	Human nuclear pre-60S ribosomal subunit (State L1)	electron microscopy	LG	MG	3 (best 0.89)
8FLE	Human nuclear pre-60S ribosomal subunit (State L2)	electron microscopy	LG	MG	3 (best 0.88)
8FLF	Human nuclear pre-60S ribosomal subunit (State L3)	electron microscopy	LG	MG	2 (best 0.87)
8G5Y	mRNA decoding in human is kinetically and structurally distinct from bacteria (IC state)	electron microscopy	LV	MG	1 (best 0.86)
8G5Z	mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state)	electron microscopy	LV	K, MG	2 (best 0.88)
8G60	mRNA decoding in human is kinetically and structurally distinct from bacteria (CR state)	electron microscopy	LV	MG	1 (best 0.88)
8G61	mRNA decoding in human is kinetically and structurally distinct from bacteria (AC state)	electron microscopy	LV	MG	1 (best 0.88)
8G6J	mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state 2)	electron microscopy	LV	K, MG	1 (best 0.87)
8GLP	mRNA decoding in human is kinetically and structurally distinct from bacteria (Consensus LSU…	electron microscopy	LV	K, MG	1 (best 0.86)
8IDT	human nuclear pre-60S ribosomal particle - State G	electron microscopy	e	—	4 (best 0.88)
8IDY	human nuclear pre-60S ribosomal particle - State F	electron microscopy	e	—	2 (best 0.87)
8IE3	human nuclear pre-60S ribosomal particle - State E	electron microscopy	e	—	2 (best 0.89)

34 records more on the page itself.

Ligands

MG · Magnesium ion · in 61 records
K · Potassium ion · in 9 records

Experiment against prediction

9GMO chain P against the predicted model P62829: TM-score 0.99, RMSD 0.43 Å
8A3D chain P against the predicted model P62829: TM-score 0.99, RMSD 0.44 Å
7OW7 chain Q against the predicted model P62829: TM-score 0.99, RMSD 0.46 Å
6LQM chain e against the predicted model P62829: TM-score 0.99, RMSD 0.50 Å
6LSR chain e against the predicted model P62829: TM-score 0.98, RMSD 0.55 Å
9C3H chain LV against the predicted model P62829: TM-score 0.98, RMSD 0.70 Å
8QFD chain V against the predicted model P62829: TM-score 0.98, RMSD 0.70 Å
4V6X chain CV against the predicted model P62829: TM-score 0.98, RMSD 0.61 Å
8FKS chain LG against the predicted model P62829: TM-score 0.98, RMSD 0.57 Å
8FKR chain LG against the predicted model P62829: TM-score 0.98, RMSD 0.57 Å

Elsewhere

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