UniProt P62744
AP-2 complex subunit sigma (P62744)
AP-2 complex subunit sigma (UniProt P62744): 7 experimental structures and 1 predicted model on GenesisL1, 16 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P62744
- Protein
- AP-2 complex subunit sigma
- Experimental structures
- 7
- Predicted models
- 1
- Pockets
- 16 · 2 records with a druggable one
Structures
8 records of P62744 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4NEE | crystal structure of AP-2 alpha/simga2 complex bound to HIV-1 Nef | x-ray diffraction | D, L, F, I | — | — |
| 4NEE | Crystal structure of ap-2 ALPHA/SIMGA2 complex bound to HIV-1 nef | x-ray diffraction | D, L, F, I | — | — |
| 6OWO | Cryo-EM structure of phosphorylated ap-2 core bound to necap | electron microscopy | S | — | 7 (best 0.83) |
| 6OWO | Cryo-EM structure of phosphorylated ap-2 core bound to necap | electron microscopy | S | — | — |
| 6OWT | Structure of sivsmm nef and smm tetherin bound to the clathrin adaptor ap-2 complex | electron microscopy | S | — | — |
| 6OXL | CRYO-EM STRUCTURE OF PHOSPHORYLATED AP-2 (mu E302K) BOUND TO NECAP IN THE PRESENCE OF SS DNA | electron microscopy | S | — | 9 (best 0.85) |
| 6OXL | Cryo-EM structure of phosphorylated ap-2 (mu E302K) bound to necap in the presence of ss DNA | electron microscopy | S | — | — |
| P62744 | AlphaFold monomer V2.0 prediction for ap-2 complex subunit sigma (P62744) | predicted | A | — | — |
Experiment against prediction
- 6OWO chain S against the predicted model P62744: TM-score 0.98, RMSD 0.59 Å
- 6OWO chain S against the predicted model P62744: TM-score 0.98, RMSD 0.59 Å
- 4NEE chain I against the predicted model P62744: TM-score 0.98, RMSD 0.60 Å
- 4NEE chain I against the predicted model P62744: TM-score 0.98, RMSD 0.60 Å
- 6OXL chain S against the predicted model P62744: TM-score 0.98, RMSD 0.60 Å
- 6OXL chain S against the predicted model P62744: TM-score 0.98, RMSD 0.60 Å
- 4NEE chain F against the predicted model P62744: TM-score 0.98, RMSD 0.69 Å
- 4NEE chain F against the predicted model P62744: TM-score 0.98, RMSD 0.69 Å
- 4NEE chain D against the predicted model P62744: TM-score 0.98, RMSD 0.68 Å
- 4NEE chain D against the predicted model P62744: TM-score 0.98, RMSD 0.68 Å
Elsewhere
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