UniProt P62068
Ubiquitin carboxyl-terminal hydrolase 46 (P62068)
Ubiquitin carboxyl-terminal hydrolase 46 (UniProt P62068), EC 3.4.19.12: 10 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 35 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P62068
- Protein
- Ubiquitin carboxyl-terminal hydrolase 46
- EC
- 3.4.19.12
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 35 · 3 records with a druggable one
Structures
11 records of P62068 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5CVM | USP46~ubiquitin BEA covalent complex | x-ray diffraction | A | ZN | 4 (best 0.48) |
| 5CVM | USP46~UBIQUITIN bea covalent complex | x-ray diffraction | A | — | — |
| 5CVN | WDR48 (2-580):USP46~ubiquitin ternary complex | x-ray diffraction | B | ZN | 7 (best 0.81) |
| 5CVN | WDR48 (2-580):USP46~UBIQUITIN ternary complex | x-ray diffraction | B | — | — |
| 5CVO | WDR48:USP46~ubiquitin ternary complex | x-ray diffraction | B, E | ZN | 15 (best 0.81) |
| 5CVO | WDR48:USP46~UBIQUITIN ternary complex | x-ray diffraction | B, E | — | — |
| 5L8H | Structure of USP46-UbVME | x-ray diffraction | A | ZN | — |
| 5L8H | Structure of USP46-ubvme | x-ray diffraction | A | GVE, ZN | — |
| 6JLQ | Crystal structure of human USP46-WDR48-WDR20 complex | x-ray diffraction | A | ZN | 6 (best 0.82) |
| 6JLQ | Crystal structure of human USP46-WDR48-WDR20 complex | x-ray diffraction | A | ZN | — |
| P62068 | AlphaFold monomer V2.0 prediction for ubiquitin carboxyl-terminal hydrolase 46 (P62068) | predicted | A | — | 3 (best 0.45) |
Ligands
Experiment against prediction
- 5L8H chain A against the predicted model P62068: TM-score 0.99, RMSD 0.79 Å
- 5L8H chain A against the predicted model P62068: TM-score 0.99, RMSD 0.79 Å
- 5CVM chain A against the predicted model P62068: TM-score 0.99, RMSD 0.79 Å
- 5CVM chain A against the predicted model P62068: TM-score 0.99, RMSD 0.79 Å
- 5CVO chain B against the predicted model P62068: TM-score 0.97, RMSD 1.42 Å
- 5CVO chain B against the predicted model P62068: TM-score 0.97, RMSD 1.42 Å
- 5CVN chain B against the predicted model P62068: TM-score 0.97, RMSD 1.40 Å
- 5CVN chain B against the predicted model P62068: TM-score 0.97, RMSD 1.40 Å
- 5CVO chain E against the predicted model P62068: TM-score 0.97, RMSD 1.43 Å
- 6JLQ chain A against the predicted model P62068: TM-score 0.93, RMSD 2.11 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.