UniProt P61175
50S ribosomal protein L22 (P61175)
50S ribosomal protein L22 (UniProt P61175): 344 experimental structures and 1 predicted model on GenesisL1, 15 ligands bound, 279 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P61175
- Protein
- 50S ribosomal protein L22
- Experimental structures
- 344
- Predicted models
- 1
- Ligands
- 15
- Pockets
- 279 · 156 records with a druggable one
Structures
345 records of P61175 in the MolNFT archive: 344 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2J28 | Model of E. COLI srp bound to 70S rncs | electron microscopy | S | — | — |
| 2J28 | Model of E. COLI srp bound to 70S rncs | electron microscopy | S | — | — |
| 2RDO | 50S subunit with EF-G(GDPNP) and RRF bound | electron microscopy | S | — | — |
| 2RDO | 50S subunit with ef-G(GDPNP) and rrf bound | electron microscopy | S | — | — |
| 3BBX | The Hsp15 protein fitted into the low resolution Cryo-EM map of the 50S.nc-tRNA.Hsp15 complex | electron microscopy | S | — | — |
| 3BBX | The HSP15 protein fitted into the low resolution cryo-EM MAP of the 50S.NC-TRNA.HSP15 complex | electron microscopy | S | — | — |
| 3J5L | Structure of the E. coli 50S subunit with ErmBL nascent chain | electron microscopy | S | — | — |
| 3J5L | Structure of the E. COLI 50S subunit with ermbl nascent chain | electron microscopy | S | — | — |
| 3J7Z | Structure of the E. coli 50S subunit with ErmCL nascent chain | electron microscopy | S | — | — |
| 3J7Z | Structure of the E. COLI 50S subunit with ermcl nascent chain | electron microscopy | S | — | — |
| 3J9Y | Cryo-EM structure of tetracycline resistance protein TetM bound to a translating E.coli ribosome | electron microscopy | S | — | — |
| 3J9Z | Activation of GTP Hydrolysis in mRNA-tRNA Translocation by Elongation Factor G | electron microscopy | LQ | — | — |
| 3JA1 | Activation of GTP Hydrolysis in mRNA-tRNA Translocation by Elongation Factor G | electron microscopy | LU | — | — |
| 3JBU | Mechanisms of Ribosome Stalling by SecM at Multiple Elongation Steps | electron microscopy | s | — | — |
| 3JBV | Mechanisms of Ribosome Stalling by SecM at Multiple Elongation Steps | electron microscopy | s | — | — |
| 3JCD | Structure of Escherichia coli EF4 in posttranslocational ribosomes (Post EF4) | electron microscopy | S | — | — |
| 3JCE | Structure of Escherichia coli EF4 in pretranslocational ribosomes (Pre EF4) | electron microscopy | S | — | — |
| 3JCJ | Structures of ribosome-bound initiation factor 2 reveal the mechanism of subunit association | electron microscopy | R | — | — |
| 3JCN | Structures of ribosome-bound initiation factor 2 reveal the mechanism of subunit association… | electron microscopy | S | — | — |
| 4CSU | Cryo-EM structures of the 50S ribosome subunit bound with ObgE | electron microscopy | S | — | — |
| 4CSU | Cryo-EM structures of the 50S ribosome subunit bound with obge | electron microscopy | S | — | — |
| 4U1U | Crystal structure of the E. coli ribosome bound to quinupristin. | x-ray diffraction | BS, DS | — | — |
| 4U1V | Crystal structure of the E. coli ribosome bound to linopristin. | x-ray diffraction | BS, DS | — | — |
| 4U20 | Crystal structure of the E. coli ribosome bound to flopristin. | x-ray diffraction | BS, DS | — | — |
| 4U24 | Crystal structure of the E. coli ribosome bound to dalfopristin. | x-ray diffraction | BS, DS | — | — |
| 4U25 | Crystal structure of the E. coli ribosome bound to virginiamycin M1. | x-ray diffraction | BS, DS | — | — |
| 4U26 | Crystal structure of the E. coli ribosome bound to dalfopristin and quinupristin. | x-ray diffraction | BS, DS | — | — |
| 4U27 | Crystal structure of the E. coli ribosome bound to flopristin and linopristin. | x-ray diffraction | BS, DS | — | — |
| 4V47 | Real space refined coordinates of the 30S and 50S subunits fitted into the low resolution cryo-EM… | electron microscopy | AQ | — | — |
| 4V48 | Real space refined coordinates of the 30S and 50S subunits fitted into the low resolution cryo-EM… | electron microscopy | AQ | — | — |
| 4V4H | Crystal structure of the bacterial ribosome from Escherichia coli in complex with the antibiotic… | x-ray diffraction | BS, DS | — | — |
| 4V4Q | Crystal structure of the bacterial ribosome from Escherichia coli at 3.5 A resolution. | x-ray diffraction | BS, DS | — | — |
| 4V4V | Structure of a pre-translocational E. coli ribosome obtained by fitting atomic models for RNA and… | electron microscopy | BQ | — | — |
| 4V4W | Structure of a SecM-stalled E. coli ribosome complex obtained by fitting atomic models for RNA and… | electron microscopy | BQ | — | — |
| 4V50 | Crystal Structure of Ribosome with messenger RNA and the Anticodon stem-loop of P-site tRNA. | x-ray diffraction | BS, DS | — | — |
| 4V52 | Crystal structure of the bacterial ribosome from Escherichia coli in complex with neomycin. | x-ray diffraction | BS, DS | — | — |
| 4V53 | Crystal structure of the bacterial ribosome from Escherichia coli in complex with gentamicin. | x-ray diffraction | BS, DS | — | — |
| 4V54 | Crystal structure of the bacterial ribosome from Escherichia coli in complex with ribosome… | x-ray diffraction | BS, DS | — | — |
| 4V55 | Crystal structure of the bacterial ribosome from Escherichia coli in complex with gentamicin and… | x-ray diffraction | BS, DS | — | — |
| 4V56 | Crystal structure of the bacterial ribosome from Escherichia coli in complex with spectinomycin. | x-ray diffraction | BS, DS | — | — |
| 4V57 | Crystal structure of the bacterial ribosome from Escherichia coli in complex with spectinomycin and… | x-ray diffraction | BS, DS | — | — |
| 4V5H | E.Coli 70s Ribosome Stalled During Translation Of Tnac Leader Peptide. | electron microscopy | BS | — | — |
| 4V5Y | Crystal structure of the bacterial ribosome from Escherichia coli in complex with paromomycin and… | x-ray diffraction | BS, DS | — | — |
| 4V64 | Crystal structure of the bacterial ribosome from Escherichia coli in complex with hygromycin B. | x-ray diffraction | BS, DS | — | — |
| 4V65 | Structure of the E. coli ribosome in the Pre-accommodation state | electron microscopy | BL | — | — |
| 4V66 | Structure of the E. coli ribosome and the tRNAs in Post-accommodation state | electron microscopy | BL | — | — |
| 4V69 | Ternary complex-bound E.coli 70S ribosome. | electron microscopy | BS | — | — |
| 4V6C | Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting | x-ray diffraction | BS, DS | — | — |
| 4V6D | Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting | x-ray diffraction | BS, DS | — | — |
| 4V6E | Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting | x-ray diffraction | BS, DS | — | — |
| 4V6K | Structural insights into cognate vs. near-cognate discrimination during decoding. | electron microscopy | AT | — | — |
| 4V6L | Structural insights into cognate vs. near-cognate discrimination during decoding. | electron microscopy | BT | — | — |
| 4V6M | Structure of the ribosome-SecYE complex in the membrane environment | electron microscopy | BS | — | — |
| 4V6N | Structural characterization of mRNA-tRNA translocation intermediates (50S ribosome of class2 of the… | electron microscopy | AU | — | — |
| 4V6O | Structural characterization of mRNA-tRNA translocation intermediates (class 4a of the six classes) | electron microscopy | BU | — | — |
| 4V6P | Structural characterization of mRNA-tRNA translocation intermediates (class 4b of the six classes) | electron microscopy | BU | — | — |
| 4V6Q | Structural characterization of mRNA-tRNA translocation intermediates (class 5 of the six classes) | electron microscopy | BU | — | — |
| 4V6R | Structural characterization of mRNA-tRNA translocation intermediates (class 6 of the six classes) | electron microscopy | BU | — | — |
| 4V6S | Structural characterization of mRNA-tRNA translocation intermediates (class 3 of the six classes) | electron microscopy | AU | — | — |
| 4V6T | Structure of the bacterial ribosome complexed by tmRNA-SmpB and EF-G during translocation and… | electron microscopy | BS | — | — |
285 records more on the page itself.
Ligands
- MG · Magnesium ion · in 30 records
- SPD · Spermidine · in 12 records
- TRP · Tryptophan · in 4 records
- K · Potassium ion · in 3 records
- DI0 · Dirithromycin · in 2 records
- UNX · Unknown atom or ion · in 2 records
- EM1 · (3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-1-{4-[4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl]butyl}-4-ethyl-7-fluoro-11-methoxy-3a ,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxotetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranoside · in 1 record
- ERY · Erythromycin A · in 1 record
- PUT · 1,4-diaminobutane · in 1 record
- SCM · Spectinomycin · in 1 record
- TEL · Telithromycin · in 1 record
- UI6 · 2-{[(2S,3R,4S,6R)-2-{[(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-13-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,6,8,10,12,14-heptamethyl-15-oxo-1-oxa-6-azacyclopentadecan-11-yl]oxy}-3-hydroxy-6-methyloxan-4-yl](methyl)amino}-N-{[(5S)-3-{(4M)-3-fluoro-4-[(6P)-6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide (non-preferred name) · in 1 record
- UIU · N-acetyl-L-tyrosyl-N-[(3M)-3-(1-{4-[(3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-10-{[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}dodecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-1(4H)-yl]butyl}-1H-1,2,3-triazol-4-yl)phenyl]-L-methioninamide · in 1 record
- UK3 · (2~{R})-~{N}-[(2~{R})-6-azanyl-1-[[(2~{R})-1-[[(2~{R})-1-[[3-[1-[4-[(1~{S},2~{R},5~{S},7~{R},8~{R},9~{R},11~{R},13~{R},14~{R})-8-[(2~{S},3~{R},4~{S},6~{R})-4-(dimethylamino)-6-methyl-3-oxidanyl-oxan-2-yl]oxy-2-ethyl-5-fluoranyl-9-methoxy-1,5,7,11,13-pentamethyl-4,6,12,16-tetrakis(oxidanylidene)-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-15-yl]butyl]-1,2,3-triazol-4-yl]phenyl]amino]-4-methylsulfanyl-1-oxidanylidene-butan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxidanylidene-propan-2-yl]amino]-1-oxidany · in 1 record
- ZIT · Azithromycin · in 1 record
Experiment against prediction
- 5J5B chain DT against the predicted model P61175: TM-score 0.98, RMSD 0.61 Å
- 5J7L chain DT against the predicted model P61175: TM-score 0.98, RMSD 0.62 Å
- 5JC9 chain DT against the predicted model P61175: TM-score 0.98, RMSD 0.62 Å
- 4YBB chain DT against the predicted model P61175: TM-score 0.98, RMSD 0.62 Å
- 5KCR chain 1W against the predicted model P61175: TM-score 0.98, RMSD 0.63 Å
- 5IT8 chain DT against the predicted model P61175: TM-score 0.97, RMSD 0.64 Å
- 8E36 chain P against the predicted model P61175: TM-score 0.97, RMSD 0.65 Å
- 5J5B chain CT against the predicted model P61175: TM-score 0.97, RMSD 0.68 Å
- 7P3K chain r against the predicted model P61175: TM-score 0.97, RMSD 0.66 Å
- 8E30 chain P against the predicted model P61175: TM-score 0.97, RMSD 0.66 Å
Elsewhere
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