UniProt P60899
DNA-directed RNA polymerase II subunit RPB9 (P60899)
DNA-directed RNA polymerase II subunit RPB9 (UniProt P60899): 47 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 25 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P60899
- Protein
- DNA-directed RNA polymerase II subunit RPB9
- Experimental structures
- 47
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 25 · 10 records with a druggable one
Structures
48 records of P60899 in the MolNFT archive: 47 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6EXV | Structure of mammalian RNA polymerase II elongation complex inhibited by alpha-amanitin | electron microscopy | I | ZN | — |
| 6GMH | Structure of activated transcription complex Pol II-DSIF-PAF-SPT6 | electron microscopy | I | ZN | — |
| 6GMH | Structure of activated transcription complex pol II-dsif-paf-SPT6 | electron microscopy | I | ZN | — |
| 6GML | Structure of paused transcription complex pol II-dsif-nelf | electron microscopy | I | ZN | — |
| 6TED | Structure of complete, activated transcription complex pol II-dsif- paf-SPT6 uncovers allosteric… | electron microscopy | I | ZN | — |
| 7B0Y | Structure of a transcribing RNA polymerase II-U1 snrnp complex | electron microscopy | I | ZN | — |
| 7B7U | Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2 | electron microscopy | I | ZN | — |
| 7EDX | P53-bound tfiid-based core pic on HDM2 promoter | electron microscopy | w | ZN | — |
| 7EG7 | Tfiid-based core pic on scp promoter | electron microscopy | w | ZN | — |
| 7EG8 | Tfiid-based core pic on puma promoter | electron microscopy | w | ZN | — |
| 7EG9 | Tfiid-based intermediate pic on scp promoter | electron microscopy | w | ZN | — |
| 7EGA | TFIID-based intermediate PIC on PUMA promoter | electron microscopy | w | ZN | — |
| 7EGA | Tfiid-based intermediate pic on puma promoter | electron microscopy | w | ZN | — |
| 7EGC | p53-bound TFIID-based holo PIC on HDM2 promoter | electron microscopy | w | ZN | — |
| 7ENA | TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) | electron microscopy | PI | ZN | — |
| 7ENC | TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) | electron microscopy | PI | ZN | — |
| 7F4G | Structure of RPAP2-bound RNA polymerase II | electron microscopy | I | ZN | — |
| 7NVR | Human Mediator with RNA Polymerase II Pre-initiation complex | electron microscopy | I | ZN | — |
| 7NVR | Human mediator with RNA polymerase II pre-initiation complex | electron microscopy | I | ZN | — |
| 7NVS | RNA polymerase II core pre-initiation complex with closed promoter DNA in proximal position | electron microscopy | I | ZN | 4 (best 0.83) |
| 7NVS | RNA polymerase II core pre-initiation complex with closed promoter DNA in proximal position | electron microscopy | I | ZN | — |
| 7NVT | RNA polymerase II core pre-initiation complex with closed promoter DNA in distal position | electron microscopy | I | ZN | — |
| 7NVU | RNA polymerase II core pre-initiation complex with open promoter DNA | electron microscopy | I | ZN | — |
| 7NVY | RNA polymerase II pre-initiation complex with closed promoter DNA in proximal position | electron microscopy | I | ZN | — |
| 7NVZ | RNA polymerase II pre-initiation complex with closed promoter DNA in distal position | electron microscopy | I | ZN | — |
| 7NW0 | RNA polymerase II pre-initiation complex with open promoter DNA | electron microscopy | I | ZN | — |
| 7OKX | Structure of active transcription elongation complex Pol II-DSIF (SPT5-KOW5)-ELL2-EAF1 (composite… | electron microscopy | I | ZN | 4 (best 0.78) |
| 7OKX | Structure of active transcription elongation complex pol II-dsif (SPT5-KOW5)-ELL2-EAF1 (composite… | electron microscopy | I | ZN | — |
| 7OKY | Structure of active transcription elongation complex pol II-dsif-ELL2- EAF1(COMPOSITE structure) | electron microscopy | I | ZN | — |
| 7OL0 | Structure of active transcription elongation complex Pol II-DSIF (SPT5-KOW5) | electron microscopy | I | ZN | 3 (best 0.78) |
| 7OL0 | Structure of active transcription elongation complex pol II-dsif (SPT5-KOW5) | electron microscopy | I | ZN | — |
| 7OO3 | Pol II-csb-csa-DDB1-uvssa (STRUCTURE1) | electron microscopy | I | ZN | — |
| 7OOB | Pol II-CSB-CSA-DDB1-UVSSA-ADPBeF3 (Structure2) | electron microscopy | I | ZN | 2 (best 0.85) |
| 7OOB | Pol II-csb-csa-DDB1-uvssa-ADPBEF3 (STRUCTURE2) | electron microscopy | I | ZN | — |
| 7OOP | Pol II-csb-csa-DDB1-uvssa-paf-SPT6 (structure 3) | electron microscopy | I | ZN | — |
| 7OPC | Pol II-csb-CRL4CSA-uvssa-SPT6-paf (structure 4) | electron microscopy | I | ZN | — |
| 7OPD | Pol II-csb-CRL4CSA-uvssa-SPT6-paf (structure 5) | electron microscopy | I | ZN | — |
| 7OZN | RNA polymerase II dimer (class 1) | electron microscopy | I, U | ZN | — |
| 7OZO | RNA polymerase II dimer (class 2) | electron microscopy | I, U | ZN | — |
| 7OZP | RNA polymerase II dimer (class 3) | electron microscopy | I, U | ZN | — |
| 7YCX | The structure of INTAC-PEC complex | electron microscopy | 7 | ZN | 1 (best 0.84) |
| 8BZ1 | RNA polymerase II core pre-initiation complex with the proximal +1 nucleosome (cPIC-Nuc10W) | electron microscopy | I | ZN | — |
| 8P4E | Structural insights into human co-transcriptional capping - structure 5 | electron microscopy | I | ZN | 3 (best 0.80) |
| 8W8E | human co-transcriptional RNA capping enzyme RNGTT | electron microscopy | I | ZN | 2 (best 0.79) |
| 9EGY | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-nucleosome, bp +27 | electron microscopy | I | ZN | 2 (best 0.76) |
| 9EH2 | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-FACT nucleosome upstream | electron microscopy | I | ZN | 2 (best 0.78) |
| 9FD2 | Structure of Pol II-TC-NER-STK19 complex | electron microscopy | I | ZN | 2 (best 0.88) |
| P60899 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase II subunit RPB9 (P60899) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 47 records
Experiment against prediction
- 7EDX chain w against the predicted model P60899: TM-score 0.89, RMSD 1.39 Å
- 7EG7 chain w against the predicted model P60899: TM-score 0.89, RMSD 1.39 Å
- 7EG9 chain w against the predicted model P60899: TM-score 0.89, RMSD 1.39 Å
- 7EGC chain w against the predicted model P60899: TM-score 0.89, RMSD 1.39 Å
- 7EG8 chain w against the predicted model P60899: TM-score 0.89, RMSD 1.39 Å
- 7EGA chain w against the predicted model P60899: TM-score 0.89, RMSD 1.39 Å
- 7EGA chain w against the predicted model P60899: TM-score 0.89, RMSD 1.39 Å
- 6EXV chain I against the predicted model P60899: TM-score 0.89, RMSD 1.55 Å
- 7ENA chain PI against the predicted model P60899: TM-score 0.88, RMSD 1.45 Å
- 6TED chain I against the predicted model P60899: TM-score 0.87, RMSD 1.57 Å
Elsewhere
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