UniProt P60228
Eukaryotic translation initiation factor 3 subunit E (P60228)
Eukaryotic translation initiation factor 3 subunit E (UniProt P60228): 11 experimental structures and 1 predicted model on GenesisL1, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P60228
- Protein
- Eukaryotic translation initiation factor 3 subunit E
- Experimental structures
- 11
- Predicted models
- 1
- Pockets
- 10 · 7 records with a druggable one
Structures
12 records of P60228 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6YBD | Structure of a human 48S translational initiation complex - EIF3 | electron microscopy | v | — | — |
| 6ZON | SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 1 | electron microscopy | E | — | 1 (best 0.83) |
| 7A09 | Structure of a human ABCE1-bound 43S pre-initiation complex - State III | electron microscopy | E | — | — |
| 7QP6 | Structure of the human 48S initiation complex in open state (h48S AUG open) | electron microscopy | v | — | — |
| 7QP7 | Structure of the human 48S initiation complex in closed state (h48S AUG closed) | electron microscopy | v | — | 1 (best 0.84) |
| 8OZ0 | Structure of a human 48S translation initiation complex with eIF4F and eIF4A | electron microscopy | 5 | — | — |
| 8PJ1 | Structure of human 48S translation initiation complex in open codon scanning state (48S-1) | electron microscopy | v | — | 1 (best 0.85) |
| 8PJ6 | Structure of human 48S translation initiation complex with initiator tRNA, eIF1A and eIF3… | electron microscopy | v | — | 1 (best 0.85) |
| 8PPL | MERS-CoV Nsp1 bound to the human 43S pre-initiation complex | electron microscopy | Iv | — | 1 (best 0.86) |
| 8RG0 | Structure of human eIF3 core from closed 48S translation initiation complex | electron microscopy | v | — | 3 (best 0.87) |
| 8XXN | Cryo-EM structure of the human 43S ribosome with PDCD4 | electron microscopy | 3E | — | 2 (best 0.86) |
| P60228 | AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 3 subunit E (P60228) | predicted | A | — | — |
Experiment against prediction
- 8PPL chain Iv against the predicted model P60228: TM-score 0.92, RMSD 1.37 Å
- 8OZ0 chain 5 against the predicted model P60228: TM-score 0.88, RMSD 1.83 Å
- 6ZON chain E against the predicted model P60228: TM-score 0.87, RMSD 2.29 Å
- 8XXN chain 3E against the predicted model P60228: TM-score 0.87, RMSD 2.31 Å
- 7A09 chain E against the predicted model P60228: TM-score 0.86, RMSD 2.43 Å
- 8PJ1 chain v against the predicted model P60228: TM-score 0.83, RMSD 2.54 Å
- 6YBD chain v against the predicted model P60228: TM-score 0.83, RMSD 2.94 Å
- 8RG0 chain v against the predicted model P60228: TM-score 0.83, RMSD 2.58 Å
- 7QP6 chain v against the predicted model P60228: TM-score 0.82, RMSD 2.86 Å
- 7QP7 chain v against the predicted model P60228: TM-score 0.82, RMSD 2.96 Å
Elsewhere
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