UniProt P59594
Spike glycoprotein (P59594)
Spike glycoprotein (UniProt P59594): 80 experimental structures and 6 predicted models on GenesisL1, 4 ligands bound, 137 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P59594
- Protein
- Spike glycoprotein
- Experimental structures
- 80
- Predicted models
- 6
- Ligands
- 4
- Pockets
- 137 · 9 records with a druggable one
Structures
86 records of P59594 in the MolNFT archive: 80 experimental, 6 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1WNC | Crystal structure of the SARS-CoV Spike protein fusion core | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1WNC | Crystal structure of the SARS-cov spike protein fusion core | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1WYY | Post-fusion hairpin conformation of the sars coronavirus spike glycoprotein | x-ray diffraction | A, B | — | — |
| 1WYY | Post-fusion hairpin conformation of the SARS coronavirus spike glycoprotein | x-ray diffraction | A, B | — | — |
| 1ZV7 | A structure-based mechanism of SARS virus membrane fusion | x-ray diffraction | A, B | — | — |
| 1ZV7 | A structure-based mechanism of SARS virus membrane fusion | x-ray diffraction | A, B | — | — |
| 1ZV8 | A structure-based mechanism of SARS virus membrane fusion | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 1ZV8 | A structure-based mechanism of SARS virus membrane fusion | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 1ZVA | A structure-based mechanism of SARS virus membrane fusion | x-ray diffraction | A | — | — |
| 1ZVA | A structure-based mechanism of SARS virus membrane fusion | x-ray diffraction | A | — | — |
| 1ZVB | A structure-based mechanism of SARS virus membrane fusion | x-ray diffraction | A, B, C | — | — |
| 1ZVB | A structure-based mechanism of SARS virus membrane fusion | x-ray diffraction | A, B, C | — | — |
| 2AJF | Structure of SARS coronavirus spike receptor-binding domain complexed with its receptor | x-ray diffraction | E, F | — | — |
| 2AJF | Structure of SARS coronavirus spike receptor-binding domain complexed with its receptor | x-ray diffraction | E, F | — | — |
| 2BEQ | Structure of a Proteolytically Resistant Core from the Severe Acute Respiratory Syndrome… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2BEQ | Structure of a proteolytically resistant core from the severe acute respiratory syndrome… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2BEZ | Structure of a proteolitically resistant core from the severe acute respiratory syndrome… | x-ray diffraction | C, F | — | — |
| 2BEZ | Structure of a proteolitically resistant core from the severe acute respiratory syndrome… | x-ray diffraction | C, F | — | — |
| 2DD8 | Crystal Structure of SARS-CoV Spike Receptor-Binding Domain Complexed with Neutralizing Antibody | x-ray diffraction | S | — | — |
| 2DD8 | Crystal structure of SARS-cov spike receptor-binding domain complexed with neutralizing antibody | x-ray diffraction | S | — | — |
| 2FXP | Solution Structure of the SARS-Coronavirus HR2 Domain | solution nmr | A, B, C | — | — |
| 2FXP | Solution structure of the SARS-coronavirus HR2 domain | solution nmr | A, B, C | — | — |
| 2GHV | Crystal structure of SARS spike protein receptor binding domain | x-ray diffraction | E, C | — | — |
| 2GHV | Crystal structure of SARS spike protein receptor binding domain | x-ray diffraction | E, C | — | — |
| 2GHW | Crystal structure of SARS spike protein receptor binding domain in complex with a neutralizing… | x-ray diffraction | A, C | — | — |
| 2GHW | Crystal structure of SARS spike protein receptor binding domain in complex with a neutralizing… | x-ray diffraction | A, C | — | — |
| 2RUM | Solution structure of Fusion peptide | solution nmr | A | — | — |
| 2RUM | Solution structure of fusion peptide | solution nmr | A | — | — |
| 2RUN | Solution Structure of Pre Transmembrane domain | solution nmr | A | — | — |
| 2RUN | Solution structure of pre transmembrane domain | solution nmr | A | — | — |
| 2RUO | Solution Structure of Internal Fusion Peptide | solution nmr | A | — | — |
| 2RUO | Solution structure of internal fusion peptide | solution nmr | A | — | — |
| 3BGF | X-ray crystal structure of the SARS coronavirus spike receptor binding domain in complex with… | x-ray diffraction | S, A | — | — |
| 3BGF | X-ray crystal structure of the SARS coronavirus spike receptor binding domain in complex with… | x-ray diffraction | S, A | — | — |
| 3D0G | Crystal structure of spike protein receptor-binding domain from the 2002-2003 SARS coronavirus… | x-ray diffraction | E, F | — | — |
| 3D0G | Crystal structure of spike protein receptor-binding domain from the 2002-2003 SARS coronavirus… | x-ray diffraction | E, F | — | — |
| 3D0H | Crystal structure of spike protein receptor-binding domain from the 2002-2003 SARS coronavirus… | x-ray diffraction | E, F | — | — |
| 3D0H | Crystal structure of spike protein receptor-binding domain from the 2002-2003 SARS coronavirus… | x-ray diffraction | E, F | — | — |
| 3D0I | Crystal structure of spike protein receptor-binding domain from the 2005-2006 SARS coronavirus… | x-ray diffraction | E, F | — | — |
| 3D0I | Crystal structure of spike protein receptor-binding domain from the 2005-2006 SARS coronavirus… | x-ray diffraction | E, F | — | — |
| 3SCL | Crystal structure of spike protein receptor-binding domain from SARS coronavirus epidemic strain… | x-ray diffraction | E, F | — | — |
| 3SCL | Crystal structure of spike protein receptor-binding domain from SARS coronavirus epidemic strain… | x-ray diffraction | E, F | — | — |
| 5WRG | SARS-CoV spike glycoprotein | electron microscopy | A, B, C | — | 20 (best 0.88) |
| 5WRG | SARS-cov spike glycoprotein | electron microscopy | A, B, C | — | — |
| 5X4S | Structure of the N-terminal domain (NTD)OF SARS-cov spike protein | x-ray diffraction | A | NAG | — |
| 5XJK | NMR structure and localization of a large fragment of the SARS-cov fusion protein: implications in… | solution nmr | A | — | — |
| 5XLR | Structure of SARS-CoV spike glycoprotein | electron microscopy | A, B, C | — | — |
| 5XLR | Structure of SARS-cov spike glycoprotein | electron microscopy | A, B, C | — | — |
| 5ZVM | Crystal structure of the human coronavirus SARS HR1 motif in complex with pan-covs inhibitor EK1 | x-ray diffraction | A, B, C | — | — |
| 6ACC | Trypsin-cleaved and low pH-treated SARS-cov spike glycoprotein and ACE2 complex, ACE2-free… | electron microscopy | A, B, C | — | — |
| 6ACD | Trypsin-cleaved and low pH-treated SARS-cov spike glycoprotein and ACE2 complex, ACE2-free… | electron microscopy | A, B, C | — | — |
| 6ACG | Trypsin-cleaved and low pH-treated SARS-cov spike glycoprotein and ACE2 complex, ACE2-bound… | electron microscopy | A, B, C | — | — |
| 6ACJ | Trypsin-cleaved and low pH-treated SARS-cov spike glycoprotein and ACE2 complex, ACE2-bound… | electron microscopy | A, B, C | — | — |
| 6ACK | Trypsin-cleaved and low pH-treated SARS-cov spike glycoprotein and ACE2 complex, ACE2-bound… | electron microscopy | A, B, C | — | — |
| 6CRV | SARS spike glycoprotein, stabilized variant, C3 symmetry | electron microscopy | A, B, C | NAG | — |
| 6CRW | SARS Spike Glycoprotein, Stabilized variant, single upwards S1 CTD conformation | electron microscopy | A, B, C | NAG | 20 (best 0.87) |
| 6CRW | SARS spike glycoprotein, stabilized variant, single upwards S1 ctd conformation | electron microscopy | A, B, C | NAG | — |
| 6CRX | SARS spike glycoprotein, stabilized variant, two S1 ctds in the upwards conformation | electron microscopy | B, C, A | NAG | — |
| 6CRZ | SARS spike glycoprotein, trypsin-cleaved, stabilized variant, C3 symmetry | electron microscopy | A, B, C | NAG | — |
| 6CS0 | SARS spike glycoprotein, trypsin-cleaved, stabilized variant, one S1 ctd in an upwards conformation | electron microscopy | A, B, C | NAG | — |
26 records more on the page itself.
Ligands
Experiment against prediction
- 2AJF chain E against the predicted model 3SCJ: TM-score 0.99, RMSD 0.39 Å
- 2AJF chain E against the predicted model 3SCJ: TM-score 0.99, RMSD 0.39 Å
- 2AJF chain E against the predicted model 3SCJ: TM-score 0.99, RMSD 0.39 Å
- 2AJF chain E against the predicted model 3SCJ: TM-score 0.99, RMSD 0.39 Å
- 2AJF chain F against the predicted model 3SCJ: TM-score 0.99, RMSD 0.40 Å
- 3SCL chain E against the predicted model 3SCK: TM-score 0.99, RMSD 0.42 Å
- 3SCL chain E against the predicted model 3SCK: TM-score 0.99, RMSD 0.42 Å
- 3SCL chain E against the predicted model 3SCK: TM-score 0.99, RMSD 0.42 Å
- 3SCL chain E against the predicted model 3SCK: TM-score 0.99, RMSD 0.42 Å
- 2AJF chain E against the predicted model 3SCJ: TM-score 0.99, RMSD 0.42 Å
Elsewhere
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