UniProt P56537
Eukaryotic translation initiation factor 6 (P56537)
Eukaryotic translation initiation factor 6 (UniProt P56537): 35 experimental structures and 1 predicted model on GenesisL1, 29 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P56537
- Protein
- Eukaryotic translation initiation factor 6
- Experimental structures
- 35
- Predicted models
- 1
- Pockets
- 29 · 21 records with a druggable one
Structures
36 records of P56537 in the MolNFT archive: 35 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6LQM | Cryo-EM structure of a pre-60S ribosomal subunit - state C | electron microscopy | 6 | — | — |
| 6LSS | Cryo-EM structure of a pre-60S ribosomal subunit - state preA | electron microscopy | 6 | — | — |
| 6LU8 | Cryo-EM structure of a human pre-60S ribosomal subunit - state A | electron microscopy | 6 | — | 1 (best 0.86) |
| 7OW7 | EIF6-bound large subunit of the human ribosome | electron microscopy | P | — | — |
| 8A3D | Human mature large subunit of the ribosome with eIF6 and homoharringtonine bound | electron microscopy | h | — | — |
| 8FKQ | Human nucleolar pre-60S ribosomal subunit (State A2) | electron microscopy | SK | — | 1 (best 0.85) |
| 8FKR | Human nucleolar pre-60S ribosomal subunit (State B1) | electron microscopy | SK | — | 2 (best 0.86) |
| 8FKS | Human nucleolar pre-60S ribosomal subunit (State B2) | electron microscopy | SK | — | — |
| 8FKU | Human nucleolar pre-60S ribosomal subunit (State C2) | electron microscopy | SK | — | 3 (best 0.87) |
| 8FKV | Human nucleolar pre-60S ribosomal subunit (State D1) | electron microscopy | SK | — | 3 (best 0.87) |
| 8FKW | Human nucleolar pre-60S ribosomal subunit (State D2) | electron microscopy | SK | — | 2 (best 0.89) |
| 8FKX | Human nucleolar pre-60S ribosomal subunit (State E) | electron microscopy | SK | — | 2 (best 0.87) |
| 8FKZ | Human nucleolar pre-60S ribosomal subunit (State G) | electron microscopy | SK | — | 1 (best 0.88) |
| 8FL0 | Human nucleolar pre-60S ribosomal subunit (State H) | electron microscopy | SK | — | 2 (best 0.88) |
| 8FL2 | Human nuclear pre-60S ribosomal subunit (State I1) | electron microscopy | SK | — | — |
| 8FL3 | Human nuclear pre-60S ribosomal subunit (State I2) | electron microscopy | SK | — | 1 (best 0.88) |
| 8FL4 | Human nuclear pre-60S ribosomal subunit (State I3) | electron microscopy | SK | — | — |
| 8FL6 | Human nuclear pre-60S ribosomal subunit (State J1) | electron microscopy | SK | — | 1 (best 0.87) |
| 8FL7 | Human nuclear pre-60S ribosomal subunit (State J2) | electron microscopy | SK | — | 1 (best 0.89) |
| 8FL9 | Human nuclear pre-60S ribosomal subunit (State J3) | electron microscopy | SK | — | 1 (best 0.86) |
| 8FLB | Human nuclear pre-60S ribosomal subunit (State K2) | electron microscopy | SK | — | — |
| 8FLC | Human nuclear pre-60S ribosomal subunit (State K3) | electron microscopy | SK | — | 1 (best 0.87) |
| 8FLD | Human nuclear pre-60S ribosomal subunit (State L1) | electron microscopy | SK | — | — |
| 8FLE | Human nuclear pre-60S ribosomal subunit (State L2) | electron microscopy | SK | — | — |
| 8FLF | Human nuclear pre-60S ribosomal subunit (State L3) | electron microscopy | SK | — | — |
| 8IDT | human nuclear pre-60S ribosomal particle - State G | electron microscopy | 6 | — | 1 (best 0.87) |
| 8IE3 | human nuclear pre-60S ribosomal particle - State E | electron microscopy | 6 | — | 1 (best 0.89) |
| 8INE | human nuclear pre-60S ribosomal particle - State G' | electron microscopy | 6 | — | 1 (best 0.89) |
| 8INF | human nuclear pre-60S ribosomal particle - State F' | electron microscopy | 6 | — | 1 (best 0.89) |
| 8INK | human nuclear pre-60S ribosomal particle - State D | electron microscopy | 6 | — | 1 (best 0.86) |
| 8IR1 | human nuclear pre-60S ribosomal particle - State A | electron microscopy | 6 | — | 1 (best 0.86) |
| 8IR3 | human nuclear pre-60S ribosomal particle - State B' | electron microscopy | 6 | — | 1 (best 0.87) |
| 8OHD | 60S ribosomal subunit bound to the E3-UFM1 complex - state 3 (native) | electron microscopy | K | — | — |
| 8OJ8 | 60S ribosomal subunit bound to the E3-UFM1 complex - state 1 (native) | electron microscopy | K | — | — |
| 9GMO | eIF6-bound pre-60S large ribosomal subunit incorporating mutant uL16 | electron microscopy | h | — | — |
| P56537 | AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 6 (P56537) | predicted | A | — | — |
Experiment against prediction
- 8A3D chain h against the predicted model P56537: TM-score 0.99, RMSD 0.43 Å
- 8OHD chain K against the predicted model P56537: TM-score 0.99, RMSD 0.50 Å
- 8OJ8 chain K against the predicted model P56537: TM-score 0.99, RMSD 0.53 Å
- 9GMO chain h against the predicted model P56537: TM-score 0.99, RMSD 0.54 Å
- 8FLF chain SK against the predicted model P56537: TM-score 0.99, RMSD 0.64 Å
- 8FLE chain SK against the predicted model P56537: TM-score 0.99, RMSD 0.65 Å
- 8FLD chain SK against the predicted model P56537: TM-score 0.99, RMSD 0.65 Å
- 8FKS chain SK against the predicted model P56537: TM-score 0.99, RMSD 0.65 Å
- 8FKR chain SK against the predicted model P56537: TM-score 0.99, RMSD 0.66 Å
- 7OW7 chain P against the predicted model P56537: TM-score 0.99, RMSD 0.75 Å
Elsewhere
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