UniProt P56463
Purine nucleoside phosphorylase DeoD-type (P56463)
Purine nucleoside phosphorylase DeoD-type (UniProt P56463), EC 2.4.2.1: 14 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 47 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P56463
- Protein
- Purine nucleoside phosphorylase DeoD-type
- EC
- 2.4.2.1
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 47 · 3 records with a druggable one
Structures
15 records of P56463 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6F4W | Crystal structure of H. pylori purine nucleoside phosphorylase in complex with formycin a | x-ray diffraction | A, B, C, D, E, F | FMC | — |
| 6F4X | Crystal structure of H. pylori purine nucleoside phosphorylase in complex with PO4 and formycin a | x-ray diffraction | A, B, C, D, E, F | FMC, PO4 | — |
| 6F52 | Crystal structure of H. pylori purine nucleoside phosphorylase in complex with PO4 and formycin A | x-ray diffraction | A, B, C, D, E, F | — | — |
| 6F52 | Crystal structure of H. pylori purine nucleoside phosphorylase in complex with PO4 and formycin a | x-ray diffraction | A, B, C, D, E, F | — | — |
| 6F5A | Crystal structure of H. pylori purine nucleoside phosphorylase | x-ray diffraction | A, B, C, D, E, F | — | — |
| 6F5I | Crystal structure of H. pylori purine nucleoside phosphorylase | x-ray diffraction | A, B, C, D, E, F | — | 14 (best 0.74) |
| 6F5I | Crystal structure of H. pylori purine nucleoside phosphorylase | x-ray diffraction | A, B, C, D, E, F | — | — |
| 6G7X | Crystal structure of H. pylori purine nucleoside phosphorylase soaked in PO4 | x-ray diffraction | A, B, C, D, E, F | PO4 | 13 (best 0.74) |
| 6G7X | Crystal structure of H. pylori purine nucleoside phosphorylase soaked in PO4 | x-ray diffraction | A, B, C, D, E, F | PO4 | — |
| 7OOY | Purine nucleoside PHOSPHORYLASE(DEOD-type) from H. pylori with 6- benzylthio-2-chloropurine | x-ray diffraction | A, B | PO4, 05Z | — |
| 7OOZ | Purine nucleoside PHOSPHORYLASE(DEOD-type) from H. pylori with 6- benzyloxo-2-chloropurine | x-ray diffraction | A, B | MG, 05Q, PO4 | — |
| 7OP9 | Purine nucleoside PHOSPHORYLASE(DEOD-type) from H. pylori with 2,6- dichloropurine | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | 06K, MG | — |
| 7OPA | Purine nucleoside phosphorylase(DeoD-type) from H. pylori with 6-benzylthiopurine | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | 05Z, PO4 | 20 (best 0.77) |
| 7OPA | Purine nucleoside PHOSPHORYLASE(DEOD-type) from H. pylori with 6- benzylthiopurine | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | 05Z, PO4 | — |
| P56463 | AlphaFold monomer V2.0 prediction for purine nucleoside phosphorylase deod-type (P56463) | predicted | A | — | — |
Ligands
- PO4 · Phosphate ion · in 7 records
- 05Z · 6-benzylthio-2-chloropurine · in 3 records
- FMC · (1S)-1-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-D-ribitol · in 2 records
- MG · Magnesium ion · in 2 records
- 05Q · 6-benzyloxo-2-chloropurine · in 1 record
- 06K · 2,6-bis(chloranyl)-7H-purine · in 1 record
Experiment against prediction
- 6F4X chain A against the predicted model P56463: TM-score 1.00, RMSD 0.37 Å
- 7OP9 chain A against the predicted model P56463: TM-score 1.00, RMSD 0.39 Å
- 7OP9 chain D against the predicted model P56463: TM-score 1.00, RMSD 0.40 Å
- 7OP9 chain I against the predicted model P56463: TM-score 1.00, RMSD 0.40 Å
- 7OP9 chain C against the predicted model P56463: TM-score 1.00, RMSD 0.40 Å
- 7OP9 chain G against the predicted model P56463: TM-score 0.99, RMSD 0.41 Å
- 7OP9 chain H against the predicted model P56463: TM-score 0.99, RMSD 0.41 Å
- 6F5I chain E against the predicted model P56463: TM-score 0.99, RMSD 0.41 Å
- 6F5I chain E against the predicted model P56463: TM-score 0.99, RMSD 0.41 Å
- 6G7X chain B against the predicted model P56463: TM-score 0.99, RMSD 0.41 Å
Elsewhere
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