UniProt P54764
Ephrin type-A receptor 4 (P54764)
Ephrin type-A receptor 4 (UniProt P54764), EC 2.7.10.1: 33 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 4 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P54764
- Protein
- Ephrin type-A receptor 4
- EC
- 2.7.10.1
- Experimental structures
- 33
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 4 · 0 records with a druggable one
Structures
34 records of P54764 in the MolNFT archive: 33 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2LW8 | NMR solution structure of Eph receptor | solution nmr | A | — | — |
| 2LW8 | NMR solution structure of eph receptor | solution nmr | A | — | — |
| 2WO1 | Crystal Structure of the EphA4 Ligand Binding Domain | x-ray diffraction | A, B | — | — |
| 2WO1 | Crystal structure of the EPHA4 ligand binding domain | x-ray diffraction | A, B | — | — |
| 2WO2 | Crystal Structure of the EphA4-ephrinB2 complex | x-ray diffraction | A | — | — |
| 2WO2 | Crystal structure of the EPHA4-EPHRINB2 complex | x-ray diffraction | A | — | — |
| 2WO3 | Crystal Structure of the EphA4-ephrinA2 complex | x-ray diffraction | A | — | — |
| 2WO3 | Crystal structure of the EPHA4-EPHRINA2 complex | x-ray diffraction | A | — | — |
| 3CKH | Crystal structure of Eph A4 receptor | x-ray diffraction | A, B | — | — |
| 3CKH | Crystal structure of eph A4 receptor | x-ray diffraction | A, B | — | — |
| 3GXU | Crystal structure of Eph receptor and ephrin complex | x-ray diffraction | A | — | — |
| 3GXU | Crystal structure of eph receptor and ephrin complex | x-ray diffraction | A | — | — |
| 4BK4 | crystal structure of the human EphA4 ectodomain | x-ray diffraction | A, B | — | — |
| 4BK4 | Crystal structure of the human EPHA4 ectodomain | x-ray diffraction | A, B | — | — |
| 4BK5 | crystal structure of the human EphA4 ectodomain in complex with human ephrin A5 (amine-methylated… | x-ray diffraction | A | — | — |
| 4BK5 | Crystal structure of the human EPHA4 ectodomain in complex with human ephrin A5 (amine-methylated… | x-ray diffraction | A | — | — |
| 4BKA | crystal structure of the human EphA4 ectodomain in complex with human ephrin A5 | x-ray diffraction | A | — | — |
| 4BKA | Crystal structure of the human EPHA4 ectodomain in complex with human ephrin A5 | x-ray diffraction | A | — | — |
| 4BKF | crystal structure of the human EphA4 ectodomain in complex with human ephrinB3 | x-ray diffraction | A, B | — | — |
| 4BKF | Crystal structure of the human EPHA4 ectodomain in complex with human EPHRINB3 | x-ray diffraction | A, B | — | — |
| 4M4P | Crystal structure of EPHA4 ectodomain | x-ray diffraction | A | — | — |
| 4M4P | Crystal structure of EPHA4 ectodomain | x-ray diffraction | A | — | — |
| 4M4R | Epha4 ectodomain complex with ephrin a5 | x-ray diffraction | A, C, E, G | — | — |
| 4M4R | EPHA4 ectodomain complex with ephrin A5 | x-ray diffraction | A, C, E, G | — | — |
| 4W4Z | Structure of the EphA4 LBD in complex with peptide | x-ray diffraction | A, B, C, D | — | — |
| 4W4Z | Structure of the EPHA4 lbd in complex with peptide | x-ray diffraction | A, B, C, D | — | — |
| 4W50 | Structure of the EphA4 LBD in complex with peptide | x-ray diffraction | A, B, C, D | — | — |
| 4W50 | Structure of the EPHA4 lbd in complex with peptide | x-ray diffraction | A, B, C, D | — | — |
| 5JR2 | Crystal structure of the EphA4 LBD in complex with APYd3 peptide inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 5JR2 | Crystal structure of the EPHA4 lbd in complex with APYD3 peptide inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 7OFV | NMR-guided design of potent and selective EphA4 agonistic ligands | x-ray diffraction | A | — | 2 (best 0.39) |
| 7OFV | NMR-guided design of potent and selective EPHA4 agonistic ligands | x-ray diffraction | A | VDK, VDQ | — |
| 9CY8 | Constrained b-hairpins targeting the EphA4 ligand binding domain | x-ray diffraction | A | CL | 2 (best 0.35) |
| P54764 | AlphaFold monomer V2.0 prediction for ephrin type-a receptor 4 (P54764) | predicted | A | — | — |
Ligands
Experiment against prediction
- 2WO3 chain A against the predicted model P54764: TM-score 0.99, RMSD 0.63 Å
- 2WO3 chain A against the predicted model P54764: TM-score 0.99, RMSD 0.63 Å
- 3CKH chain A against the predicted model P54764: TM-score 0.95, RMSD 1.38 Å
- 3CKH chain A against the predicted model P54764: TM-score 0.95, RMSD 1.38 Å
- 3GXU chain A against the predicted model P54764: TM-score 0.94, RMSD 1.43 Å
- 3GXU chain A against the predicted model P54764: TM-score 0.94, RMSD 1.43 Å
- 4BK4 chain B against the predicted model P54764: TM-score 0.94, RMSD 1.94 Å
- 4BK4 chain B against the predicted model P54764: TM-score 0.94, RMSD 1.94 Å
- 3CKH chain B against the predicted model P54764: TM-score 0.93, RMSD 1.68 Å
- 3CKH chain B against the predicted model P54764: TM-score 0.93, RMSD 1.68 Å
Elsewhere
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