UniProt P54687
Branched-chain-amino-acid aminotransferase, cytosolic (P54687)
Branched-chain-amino-acid aminotransferase, cytosolic (UniProt P54687), EC 2.6.1.42: 15 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 51 pockets. Binding sites, druggability and experiment against…
- UniProt
- P54687
- Protein
- Branched-chain-amino-acid aminotransferase, cytosolic
- EC
- 2.6.1.42
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 51 · 7 records with a druggable one
Structures
16 records of P54687 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2ABJ | Crystal structure of human branched chain amino acid transaminase in a complex with an inhibitor… | x-ray diffraction | A, D, G, J | — | — |
| 2ABJ | Crystal structure of human branched chain amino acid transaminase in a complex with an inhibitor… | x-ray diffraction | A, D, G, J | — | — |
| 2COG | Crystal structure of oxidized human cytosolic branched-chain aminotransferase complexed with… | x-ray diffraction | A, B | — | — |
| 2COG | Crystal structure of oxidized human cytosolic branched-chain aminotransferase complexed with… | x-ray diffraction | A, B | — | — |
| 2COI | Crystal structure of oxidized human cytosolic branched-chain aminotransferase complexed with… | x-ray diffraction | A, B | — | — |
| 2COI | Crystal structure of oxidized human cytosolic branched-chain aminotransferase complexed with… | x-ray diffraction | A, B | — | — |
| 2COJ | Crystal structure of reduced human cytosolic branched-chain aminotransferase complexed with… | x-ray diffraction | A, B | — | — |
| 2COJ | Crystal structure of reduced human cytosolic branched-chain aminotransferase complexed with… | x-ray diffraction | A, B | — | — |
| 7NTR | Crystal structure of human cytosolic branched-chain aminotransferase (BCAT1) in complex with plp… | x-ray diffraction | A, B | HCI, PLP, MG | 8 (best 0.78) |
| 7NWA | Crystal structure of human cytosolic branched-chain aminotransferase (BCAT1) in complex with plp… | x-ray diffraction | A, B | UTT, PLP, MG | 7 (best 0.80) |
| 7NWB | Crystal structure of human cytosolic branched-chain aminotransferase (BCAT1) in complex with plp… | x-ray diffraction | A, B, C, D | UTK, PLP | 12 (best 0.75) |
| 7NWM | Crystal structure of human cytosolic branched-chain aminotransferase (BCAT1) in complex with plp… | x-ray diffraction | A, B | UTN, PLP, MG | 4 (best 0.80) |
| 7NXN | Crystal structure of human cytosolic branched-chain aminotransferase (BCAT1) in complex with plp… | x-ray diffraction | A, B | UU2, PLP, MG | 5 (best 0.75) |
| 7NXO | Crystal structure of human cytosolic branched-chain aminotransferase (BCAT1) in complex with plp… | x-ray diffraction | A, B | UU8, PLP, MG | 6 (best 0.75) |
| 7NY2 | Crystal structure of human cytosolic branched-chain aminotransferase (BCAT1) in complex with plp… | x-ray diffraction | A, B | UUQ, PLP, MG | 9 (best 0.74) |
| P54687 | AlphaFold monomer V2.0 prediction for branched-chain-amino-acid aminotransferase, cytosolic (P54687) | predicted | A | — | — |
Ligands
- PLP · Pyridoxal-5'-phosphate · in 7 records
- MG · Magnesium ion · in 6 records
- HCI · Hydrocinnamic acid · in 1 record
- UTK · 4-[2,4-bis(oxidanylidene)-6-(trifluoromethyl)-1H-pyrimidin-3-yl]-5-fluoranyl-2-(2-methylphenoxy)benzenecarbonitrile · in 1 record
- UTN · 4-[2,4-bis(oxidanylidene)-6-(trifluoromethyl)-1H-pyrimidin-3-yl]-5-methoxy-2-(2-methylphenoxy)benzenecarbonitrile · in 1 record
- UTT · 2-[[4-chloranyl-2,6-bis(fluoranyl)phenyl]methylamino]-7-oxidanylidene-5-propyl-4H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile · in 1 record
- UU2 · 4-[6-[bis(fluoranyl)-phenyl-methyl]-2,4-bis(oxidanylidene)-1~{H}-pyrimidin-3-yl]-5-fluoranyl-2-(2-methylphenoxy)benzenecarbonitrile · in 1 record
- UU8 · 4-[2,4-bis(oxidanylidene)-6-(phenylsulfonyl)-1H-pyrimidin-3-yl]-5-fluoranyl-2-(2-methylphenoxy)benzenecarbonitrile · in 1 record
- UUQ · 4-[2,4-bis(oxidanylidene)-6-(trifluoromethyl)-1H-pyrimidin-3-yl]-2-(2-methylphenoxy)naphthalene-1-carbonitrile · in 1 record
Experiment against prediction
- 2ABJ chain G against the predicted model P54687: TM-score 1.00, RMSD 0.24 Å
- 2ABJ chain G against the predicted model P54687: TM-score 1.00, RMSD 0.24 Å
- 2ABJ chain D against the predicted model P54687: TM-score 1.00, RMSD 0.25 Å
- 2ABJ chain D against the predicted model P54687: TM-score 1.00, RMSD 0.25 Å
- 2ABJ chain A against the predicted model P54687: TM-score 1.00, RMSD 0.29 Å
- 2ABJ chain A against the predicted model P54687: TM-score 1.00, RMSD 0.29 Å
- 2ABJ chain J against the predicted model P54687: TM-score 1.00, RMSD 0.32 Å
- 2ABJ chain J against the predicted model P54687: TM-score 1.00, RMSD 0.32 Å
- 2COI chain B against the predicted model P54687: TM-score 1.00, RMSD 0.39 Å
- 2COI chain B against the predicted model P54687: TM-score 1.00, RMSD 0.39 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.