UniProt P53973
Histone deacetylase HDA1 (P53973)
Histone deacetylase HDA1 (UniProt P53973), EC 3.5.1.98: 8 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 35 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P53973
- Protein
- Histone deacetylase HDA1
- EC
- 3.5.1.98
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 35 · 2 records with a druggable one
Structures
9 records of P53973 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5J8J | A histone deacetylase from Saccharomyces cerevisiae | x-ray diffraction | A | — | 3 (best 0.47) |
| 5J8J | A histone deacetylase from saccharomyces cerevisiae | x-ray diffraction | A | — | — |
| 6Z6F | HDAC-PC | electron microscopy | A, B | ZN | 17 (best 0.80) |
| 6Z6F | HDAC-PC | electron microscopy | A, B | ZN | — |
| 6Z6H | HDAC-DC | electron microscopy | A, B, F, G | ZN | 15 (best 0.86) |
| 6Z6H | HDAC-DC | electron microscopy | A, B, F, G | ZN | — |
| 6Z6O | HDAC-TC | electron microscopy | A, B, E, F, I, J, M, N | ZN | — |
| 6Z6P | HDAC-PC-NUC | electron microscopy | K, L | ZN | — |
| P53973 | AlphaFold monomer V2.0 prediction for histone deacetylase HDA1 (P53973) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 6 records
Experiment against prediction
- 5J8J chain A against the predicted model P53973: TM-score 0.95, RMSD 1.77 Å
- 5J8J chain A against the predicted model P53973: TM-score 0.95, RMSD 1.77 Å
- 6Z6H chain F against the predicted model P53973: TM-score 0.83, RMSD 4.27 Å
- 6Z6H chain F against the predicted model P53973: TM-score 0.83, RMSD 4.27 Å
- 6Z6H chain A against the predicted model P53973: TM-score 0.83, RMSD 4.31 Å
- 6Z6H chain A against the predicted model P53973: TM-score 0.83, RMSD 4.31 Å
- 6Z6F chain A against the predicted model P53973: TM-score 0.83, RMSD 4.25 Å
- 6Z6F chain A against the predicted model P53973: TM-score 0.83, RMSD 4.25 Å
- 6Z6P chain K against the predicted model P53973: TM-score 0.83, RMSD 4.39 Å
- 6Z6O chain E against the predicted model P53973: TM-score 0.83, RMSD 4.32 Å
Elsewhere
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